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G protein-coupled receptor
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Revision as of 01:39, 7 September 2011
| For the date when the most recent work on this article was done, click on the history tab above. |
G protein-coupled receptors, often abbreviated GPCRs, are an abundant class of proteins also known as seven-transmembrane domain receptors, 7TM receptors, heptahelical receptors, serpentine receptor, and G protein-linked receptors (GPLRs).
[[G protein-coupled receptor|G protein-coupled receptors] are involved in many diseases, and are also the target of approximately 30% of all modern medicinal drugs [1].
Contents |
See Also
3D Structures of G protein-coupled receptors
References and Notes
- ↑ Overington JP, Al-Lazikani B, Hopkins AL. How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. PMID:17139284 doi:10.1038/nrd2199
Additional Literature
- PMID: xxxx
External Resources
- GPCRDB: database contains sequences, ligand binding constants and mutations, in addition GPCR multiple sequence alignments and homology models. Moreover, the site contains useful structure files where lysozyme and other inserts commonly used in the difficult process of crystallizing these transmembrane structures are removed.
- tinyGRAP GPCR mutant database.
- GPCR-OKB: GPCR Oligomerization Knowledge Base
- GPCR Natural Variants Database (NaVa)
- The PRED-GPCR server for GPCR recognition and family classification.
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Alexander Berchansky, Wayne Decatur, Michal Harel, Ann Taylor, Nikki Hunter
