Sandbox 31
From Proteopedia
(Difference between revisions)
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== '''Papain''' (PDB ID #: 9pap)== | == '''Papain''' (PDB ID #: 9pap)== | ||
| - | + | <StructureSection load='9pap' size='500' side='right' caption='Structure of HMG-CoA reductase (PDB entry [[9pap]])' scene=''> | |
| - | <StructureSection load='9pap' size='500' side='right' caption='Structure of HMG-CoA reductase (PDB entry [[9pap]])' scene=''>Papain is a cysteine hydrolase | + | '''Introduction''' |
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| + | Papain is a cysteine hydrolase (EC 3.4.22.2) that is found naturally occurring in [http://en.wikipedia.org/wiki/Carica_papaya Papaya](''Carica papaya''). Papain is extracted from the latex, leaves and roots of the papaya tree. Papain is a protease commonly used for cell isolation, protein structural studies, cleaving antibodies, and various other research techniques. In addition to use in research, it is commonly used in industry to tenderize meats, remove skin from hides, and clean soft contact lenses. | ||
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| + | '''Structure''' | ||
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| + | Papain is formed from a peptide that is 212 amino acids in length. It consists of 25% <scene name='Sandbox_31/Alpha_helices/3'>Alpha helices</scene> and 21% <scene name='Sandbox_31/Beta_sheet/1'> Beta sheet</scene>. The structure also consists of three <scene name='Sandbox_31/Disulfide/2'>disulfide bonds</scene> between cysteine residues. Another important residue to the structure is Cysteine 25 which has a sulfhydryl group that plays a major role in the active site activity[[http://www.sigmaaldrich.com/life-science/metabolomics/enzyme-explorer/analytical-enzymes/papain.html]]. | ||
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<scene name='Sandbox_31/Hydrophobic_residues/1'>Hydrophobic Residues</scene> | <scene name='Sandbox_31/Hydrophobic_residues/1'>Hydrophobic Residues</scene> | ||
| - | Possible ligand | ||
</StructureSection> | </StructureSection> | ||
Revision as of 20:13, 6 November 2011
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| Please do NOT make changes to this Sandbox. Sandboxes 30-60 are reserved for use by Biochemistry 410 & 412 at Messiah College taught by Dr. Hannah Tims during Fall 2012 and Spring 2013. |
Papain (PDB ID #: 9pap)
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