3clb

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Revision as of 08:47, 2 June 2012

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Template:STRUCTURE 3clb

Contents 1 Structure of bifunctional TcDHFR-TS in complex with TMQ 2 About this Structure 3 See Also 4 Reference

Structure of bifunctional TcDHFR-TS in complex with TMQ

Template:ABSTRACT PUBMED 18536013

About this Structure

3clb is a 4 chain structure of Dihydrofolate reductase and Thymidylate synthase with sequence from Trypanosoma cruzi. Full crystallographic information is available from OCA.

See Also

• Dihydrofolate reductase
• Thymidylate synthase

Reference

• Schormann N, Senkovich O, Walker K, Wright DL, Anderson AC, Rosowsky A, Ananthan S, Shinkre B, Velu S, Chattopadhyay D. Structure-based approach to pharmacophore identification, in silico screening, and three-dimensional quantitative structure-activity relationship studies for inhibitors of Trypanosoma cruzi dihydrofolate reductase function. Proteins. 2008 Dec;73(4):889-901. PMID:18536013 doi:10.1002/prot.22115