3ews

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[[Image:3ews.png|left|200px]]
[[Image:3ews.png|left|200px]]
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{{STRUCTURE_3ews| PDB=3ews | SCENE= }}
{{STRUCTURE_3ews| PDB=3ews | SCENE= }}
===Human DEAD-box RNA-helicase DDX19 in complex with ADP===
===Human DEAD-box RNA-helicase DDX19 in complex with ADP===
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*[[Dead-box RNA helicase DDX19%2C in complex with an ATP-analogue and RNA|Dead-box RNA helicase DDX19%2C in complex with an ATP-analogue and RNA]]
*[[Dead-box RNA helicase DDX19%2C in complex with an ATP-analogue and RNA|Dead-box RNA helicase DDX19%2C in complex with an ATP-analogue and RNA]]
*[[Helicase|Helicase]]
*[[Helicase|Helicase]]
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*[[Morphs|Morphs]]
 
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*[[User:Wayne Decatur|User:Wayne Decatur]]
 
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*[[User:Wayne Decatur/3ewsSLASH3g0h Morph methods|User:Wayne Decatur/3ewsSLASH3g0h Morph methods]]
 
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*[[User:Wayne Decatur/3fpn Morph methods|User:Wayne Decatur/3fpn Morph methods]]
 
==Reference==
==Reference==

Revision as of 20:46, 25 July 2012

Template:STRUCTURE 3ews

Contents

Human DEAD-box RNA-helicase DDX19 in complex with ADP

Publication Abstract from PubMed

DEXD/H-box RNA helicases couple ATP hydrolysis to RNA remodeling by an unknown mechanism. We used x-ray crystallography and biochemical analysis of the human DEXD/H-box protein DDX19 to investigate its regulatory mechanism. The crystal structures of DDX19, in its RNA-bound prehydrolysis and free posthydrolysis state, reveal an alpha-helix that inserts between the conserved domains of the free protein to negatively regulate ATPase activity. This finding was corroborated by biochemical data that confirm an autoregulatory function of the N-terminal region of the protein. This is the first study describing crystal structures of a DEXD/H-box protein in its open and closed cleft conformations.

The DEXD/H-box RNA helicase DDX19 is regulated by an {alpha}-helical switch., Collins R, Karlberg T, Lehtio L, Schutz P, van den Berg S, Dahlgren LG, Hammarstrom M, Weigelt J, Schuler H, J Biol Chem. 2009 Apr 17;284(16):10296-300. Epub 2009 Feb 25. PMID:19244245

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

About this Structure

3ews is a 2 chain structure of Helicase with sequence from Homo sapiens. Full crystallographic information is available from OCA.

See Also

Reference

  • Collins R, Karlberg T, Lehtio L, Schutz P, van den Berg S, Dahlgren LG, Hammarstrom M, Weigelt J, Schuler H. The DEXD/H-box RNA helicase DDX19 is regulated by an {alpha}-helical switch. J Biol Chem. 2009 Apr 17;284(16):10296-300. Epub 2009 Feb 25. PMID:19244245 doi:10.1074/jbc.C900018200

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OCA

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