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Acyl carrier protein synthase

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</StructureSection>
</StructureSection>
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==3D structures of acyl carrier protein synthase==
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[[1af8]], [[2af8]], [[2kg8]], [[2kg9]], [[2kga]], [[2kgc]], [[2kgd]], [[2kge]] – ScACPS – ''Streptomyces coelicolor'' – NMR<br />
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[[2jca]] - ScACPS <br />
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[[1fte]], [[1ftf]] - SpACPS – ''Streptococcus pneumoniae''<br />
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[[1f7l]], [[1f7t]] - BsACPS (mutant) – ''Bacillus subtilis''<br />
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[[3f09]] - SaACPS – ''Staphylococcus aureus''<br />
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[[3hqj]], [[3h7q]], [[3ne1]], [[3ne3]], [[3ne9]], [[3nfd]] - MtACPS – ''Mycobacterium tuberculosis''<br />
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[[3gwm]] - ACPS – ''Mycobacterium smegmatis''<br />
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[[3qmn]] - ACPS – ''Vibrio cholera''
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'''ACPS complex'''
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[[2jbz]] - ScACPS + CoA<br />
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[[2wds]], [[2wdy]] - ScACPS (mutant) + CoA<br />
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[[2wdo]] - ScACPS + acetyl-CoA<br />
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[[1fth]] – SpACPS + ADP<br />
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[[1f80]] - BsACPS (mutant) + ACP<br />
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[[2qg8]] - ACPS + ADP – ''Plasmodium yoelii''<br />
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[[4dxe]] - SaACPS + ACP<br />
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[[3hyk]] - ACPS + ADP – ''Bacillus anthracis''
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'''β-ketoacyl-ACPS'''
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[[1w0i]] - AtACPS – ''Arabidopsis thaliana''<br />
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[[2ix4]] - AtACPS + hexanoic acid<br />
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[[2c9h]], [[2iwy]], [[3hhd]] – hACPS – human<br />
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[[2iwz]] - hACPS + hexanoic acid<br />
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'''β-ketoacyl-ACPS I'''
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[[1dd8]], [[1g5x]], [[2buh]], [[2aq7]], [[2vb7]], [[2vb9]] - EcACPS I - ''Escherichia coli''<br />
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[[1h4f]], [[2byw]], [[2byy]], [[2bz4]] - EcACPS I (mutant)<br />
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[[2wgd]] - MtACPS I <br />
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[[2wgf]] - MtACPS I (mutant)<br />
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[[2was]] - yACPS I PPT domain – yeast<br />
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[[3oyt]] - ACPS I – Yersinia psetis<br />
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'''ACPS I complex'''
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[[1fj4]], [[1fj8]], [[2aqb]], [[2vb8]] - EcACPS I + antibiotic<br />
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[[2vba]] - EcACPS I + inhibitor<br />
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[[1ek4]] - EcACPS I (mutant) + dodecanoic acid<br />
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[[2bui]] - EcACPS I + octanoic acid<br />
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[[1f91]], [[2byx]], [[2byz]], [[2bz3]] - EcACPS I (mutant) + fatty acid substrate<br />
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[[2wge]] - MtACPS I + antibiotic<br />
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[[2wgg]] - MtACPS I (mutant) + antibiotic<br />
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[[2wat]] - yACPS I PPT domain + CoA<br />
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'''β-ketoacyl-ACPS II'''
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[[1e5m]] - ACPS II – ''Synechocytosis''<br />
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[[1j3n]] - TtACPS II – ''Thermus thermophilus''<br />
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[[1ox0]], [[1oxh]] - SpACPS II<br />
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[[2alm]], [[2rjt]] - MtACPS II (mutant)<br />
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[[2gqd ]] - SaACPS II <br />
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[[2gp6]] - MtACPS II <br />
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[[3e60]] – ACPS II – ''Bartonella henselae''<br />
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[[3kzu]] - ACPS II – ''Brucella melitensis''<br />
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[[3o04]] - ACPS II – ''Listeria monocytogenes''<br />
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[[4ddo]] - BvACPS II – ''Burkholderia vietnamiensis''<br />
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[[1kas]], [[2gfw]] – EcACPS II<br />
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[[2gfv]] - EcACPS II (mutant)
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'''ACPS II complex'''
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[[1b3n]] - EcACPS II + antibiotic<br />
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[[2gfx]], [[3g0y]], [[3g11]], [[3hnz]], [[3ho2]], [[3ho9]], [[3i8p]] - EcACPS II (mutant) + antibiotic<br />
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[[2gfy]] - EcACPS II (mutant) + dodecanoic acid<br />
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[[4f32]] - BvACPS II + antibiotic<br />
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'''β-ketoacyl-ACPS III'''
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[[1hzp]], [[1m1m]] - MtACPS III <br />
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[[1u6e]], [[2ahb]], [[2aj9]] - MtACPS III (mutant)<br />
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[[1mzj]] - ACPS III – ''Streptomyces''<br />
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[[1zow]], [[3il7]] - SaACPS III <br />
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[[2ebd]] - ACPS III – ''Aquifex aeolicus''<br />
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[[3gwa]], [[3gwe]] - ACPS III – ''Burkholderia pseudomallei''<br />
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[[4dfe]], [[4efi]] - ACPS III – ''Burkholderia xenovorans''<br />
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[[3il3]] - ACPS III – ''Haemophilus influenza''<br />
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[[3fk5]] - ACPS III – ''Xanthomonas oryzae''<br />
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[[3led]] - ACPS III – ''Pseudonomas palustris''<br />
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[[2x3e]] - ACPS III – ''Pseudonomas aeruginosa''<br />
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[[1ebl]], [[1hn9]], [[1hnk]], [[3il9]] - EcACPS III
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'''ACPS III complex'''
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[[1hnd]], [[1hnh]], [[2gyo]], [[2eft]] - EcACPS III + CoA<br />
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[[1hnj]] - EcACPS III + malonyl-CoA<br />
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[[2qx1]] - EcACPS III + decyl-CoA<br />
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[[1mzs]] - EcACPS III + inhibitor<br />
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[[1u6s]] - MtACPS III (mutant) + lauroyl-CoA<br />
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[[21nx]], [[2qo1]] - MtACPS III + undecanoic acid<br />
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[[2qo0]] - MtACPS III (mutant) + undecanoic acid<br />
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[[2qnz]] - MtACPS III + decyl formate<br />
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[[2qny]] - MtACPS III (mutant) + decyl formate<br />
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[[1ub7]] - TtACPS III (mutant)<br />
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[[3il4]] - EfACPS III + CoA – ''Enterococcus faecalis''<br />
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[[3il5]] - EfACPS III + benzoic acid derivative<br />
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[[3il6]] - EfACPS III (mutant) + benzoic acid derivative
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{{Clear}}
{{Clear}}

Revision as of 06:56, 15 July 2012

Acyl carrier protein synthase complex with CoA and Mg+2 ion 3hqj

Drag the structure with the mouse to rotate

3D structures of acyl carrier protein synthase

1af8, 2af8, 2kg8, 2kg9, 2kga, 2kgc, 2kgd, 2kge – ScACPS – Streptomyces coelicolor – NMR
2jca - ScACPS
1fte, 1ftf - SpACPS – Streptococcus pneumoniae
1f7l, 1f7t - BsACPS (mutant) – Bacillus subtilis
3f09 - SaACPS – Staphylococcus aureus
3hqj, 3h7q, 3ne1, 3ne3, 3ne9, 3nfd - MtACPS – Mycobacterium tuberculosis
3gwm - ACPS – Mycobacterium smegmatis
3qmn - ACPS – Vibrio cholera

ACPS complex

2jbz - ScACPS + CoA
2wds, 2wdy - ScACPS (mutant) + CoA
2wdo - ScACPS + acetyl-CoA
1fth – SpACPS + ADP
1f80 - BsACPS (mutant) + ACP
2qg8 - ACPS + ADP – Plasmodium yoelii
4dxe - SaACPS + ACP
3hyk - ACPS + ADP – Bacillus anthracis

β-ketoacyl-ACPS

1w0i - AtACPS – Arabidopsis thaliana
2ix4 - AtACPS + hexanoic acid
2c9h, 2iwy, 3hhd – hACPS – human
2iwz - hACPS + hexanoic acid

β-ketoacyl-ACPS I

1dd8, 1g5x, 2buh, 2aq7, 2vb7, 2vb9 - EcACPS I - Escherichia coli
1h4f, 2byw, 2byy, 2bz4 - EcACPS I (mutant)
2wgd - MtACPS I
2wgf - MtACPS I (mutant)
2was - yACPS I PPT domain – yeast
3oyt - ACPS I – Yersinia psetis

ACPS I complex

1fj4, 1fj8, 2aqb, 2vb8 - EcACPS I + antibiotic
2vba - EcACPS I + inhibitor
1ek4 - EcACPS I (mutant) + dodecanoic acid
2bui - EcACPS I + octanoic acid
1f91, 2byx, 2byz, 2bz3 - EcACPS I (mutant) + fatty acid substrate
2wge - MtACPS I + antibiotic
2wgg - MtACPS I (mutant) + antibiotic
2wat - yACPS I PPT domain + CoA

β-ketoacyl-ACPS II

1e5m - ACPS II – Synechocytosis
1j3n - TtACPS II – Thermus thermophilus
1ox0, 1oxh - SpACPS II
2alm, 2rjt - MtACPS II (mutant)
2gqd - SaACPS II
2gp6 - MtACPS II
3e60 – ACPS II – Bartonella henselae
3kzu - ACPS II – Brucella melitensis
3o04 - ACPS II – Listeria monocytogenes
4ddo - BvACPS II – Burkholderia vietnamiensis
1kas, 2gfw – EcACPS II
2gfv - EcACPS II (mutant)

ACPS II complex

1b3n - EcACPS II + antibiotic
2gfx, 3g0y, 3g11, 3hnz, 3ho2, 3ho9, 3i8p - EcACPS II (mutant) + antibiotic
2gfy - EcACPS II (mutant) + dodecanoic acid
4f32 - BvACPS II + antibiotic

β-ketoacyl-ACPS III

1hzp, 1m1m - MtACPS III
1u6e, 2ahb, 2aj9 - MtACPS III (mutant)
1mzj - ACPS III – Streptomyces
1zow, 3il7 - SaACPS III
2ebd - ACPS III – Aquifex aeolicus
3gwa, 3gwe - ACPS III – Burkholderia pseudomallei
4dfe, 4efi - ACPS III – Burkholderia xenovorans
3il3 - ACPS III – Haemophilus influenza
3fk5 - ACPS III – Xanthomonas oryzae
3led - ACPS III – Pseudonomas palustris
2x3e - ACPS III – Pseudonomas aeruginosa
1ebl, 1hn9, 1hnk, 3il9 - EcACPS III

ACPS III complex

1hnd, 1hnh, 2gyo, 2eft - EcACPS III + CoA
1hnj - EcACPS III + malonyl-CoA
2qx1 - EcACPS III + decyl-CoA
1mzs - EcACPS III + inhibitor
1u6s - MtACPS III (mutant) + lauroyl-CoA
21nx, 2qo1 - MtACPS III + undecanoic acid
2qo0 - MtACPS III (mutant) + undecanoic acid
2qnz - MtACPS III + decyl formate
2qny - MtACPS III (mutant) + decyl formate
1ub7 - TtACPS III (mutant)
3il4 - EfACPS III + CoA – Enterococcus faecalis
3il5 - EfACPS III + benzoic acid derivative
3il6 - EfACPS III (mutant) + benzoic acid derivative










References

  • Parris KD, Lin L, Tam A, Mathew R, Hixon J, Stahl M, Fritz CC, Seehra J, Somers WS. Crystal structures of substrate binding to Bacillus subtilis holo-(acyl carrier protein) synthase reveal a novel trimeric arrangement of molecules resulting in three active sites. Structure. 2000 Aug 15;8(8):883-95. PMID:10997907
  • Dym O, Albeck S, Peleg Y, Schwarz A, Shakked Z, Burstein Y, Zimhony O. Structure-function analysis of the acyl carrier protein synthase (AcpS) from Mycobacterium tuberculosis. J Mol Biol. 2009 Nov 6;393(4):937-50. Epub 2009 Sep 3. PMID:19733180 doi:10.1016/j.jmb.2009.08.065

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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