StudioG24SecL04Tpc5
From Proteopedia
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==VlsE== | ==VlsE== | ||
<Structure load='1l8w' size='300' frame='true' align='right' caption='IR6:Immunodominate Region of VlsE' scene='StudioG24SecL04Tpc5/Ir6_highlight/3' /> | <Structure load='1l8w' size='300' frame='true' align='right' caption='IR6:Immunodominate Region of VlsE' scene='StudioG24SecL04Tpc5/Ir6_highlight/3' /> | ||
| + | The causative agent of Lyme disease, a multi-stage infection, is a family of spirochetes found in the guts of Ixodes ticks. The Variable Major Protein (VMP)-like sequence Expressed (VlsE) is the specific outer-surface lipoprotein that enables the spirochete to evade immune response through mechanisms of antigenic variation. In addition to inducing a strong immune response in the host, VlsE is useful in the serodiagnosis of Lyme disease (Eicken et al.). | ||
==Structural Overview== | ==Structural Overview== | ||
Revision as of 18:53, 14 August 2012
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*This representation of VlsE illustrates the only crystal structure available on the PDB site. |
Contents |
VlsE
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The causative agent of Lyme disease, a multi-stage infection, is a family of spirochetes found in the guts of Ixodes ticks. The Variable Major Protein (VMP)-like sequence Expressed (VlsE) is the specific outer-surface lipoprotein that enables the spirochete to evade immune response through mechanisms of antigenic variation. In addition to inducing a strong immune response in the host, VlsE is useful in the serodiagnosis of Lyme disease (Eicken et al.).
Structural Overview
VlsE is shown to be composed of four sub-units, each consisting of a variable domain flanked by two invariable domains (Liang). The variable domains themselves contain six variable regions (VR) interspersed amongst six invariable regions (IR). The IRs are embedded deep within the protein covered by alpha helical loops. They are shielded by the VRs.
Antigenicity
Function in Immune System Evasion
Additional Links
Antigenic Variation
Lyme Disease
