Sandbox Zdenek
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
== Structural maintenance of chromosomes protein complexes == | == Structural maintenance of chromosomes protein complexes == | ||
<StructureSection load='3nw0' size='350' side='right' caption='Structure of MAGEG1 complex with Nse1 subunit(PDB entry [[3nw0]])' scene='Sandbox_Zdenek/Scene0/1'> | <StructureSection load='3nw0' size='350' side='right' caption='Structure of MAGEG1 complex with Nse1 subunit(PDB entry [[3nw0]])' scene='Sandbox_Zdenek/Scene0/1'> | ||
| - | The SMC5-6 protein complex is one of the three SMC (Structural maintenance of chromosomes) protein complexes present in all eukaryotes <ref>pmid 18059412, pmid 19308705 </ref>. The SMC5-6 complex is involved in chromatin dynamics such as the response to different types of DNA damage <ref> pmid 15661654 </ref>, <ref> pmid 8524274 </ref> . The core of the complex is formed by the SMC5-SMC6 heterodimer, which is associated with four conserved non-SMC proteins <ref> pmid 10747036 </ref>.<scene name='Sandbox_Zdenek/Scene2/4'>Nse1 subunit</scene> together with <scene name='Sandbox_Zdenek/Scene1/5'>MAGE-G1 subunit</scene> (homologue of Nse3) formed tight part of this complex. [[Image:smc_complex.png|200px|left|Scheme of SMC5-6 complex]]. | + | The SMC5-6 protein complex is one of the three SMC (Structural maintenance of chromosomes) protein complexes present in all eukaryotes <ref>pmid 18059412</ref>, <ref>pmid 19308705</ref>. The SMC5-6 complex is involved in chromatin dynamics such as the response to different types of DNA damage <ref>pmid 15661654</ref>, <ref> pmid 8524274</ref> . The core of the complex is formed by the SMC5-SMC6 heterodimer, which is associated with four conserved non-SMC proteins <ref> pmid 10747036 </ref>.<scene name='Sandbox_Zdenek/Scene2/4'>Nse1 subunit</scene> together with <scene name='Sandbox_Zdenek/Scene1/5'>MAGE-G1 subunit</scene> (homologue of Nse3) formed tight part of this complex. [[Image:smc_complex.png|200px|left|Scheme of SMC5-6 complex]]. |
Melanoma associated antigen (MAGE) proteins are associated also with DNA replication processes. This family of proteins contains more than 60 species divided into 6 families. As described in <ref> pmid 20864041</ref> the family is characterised by [[Coiled_coil]] <scene name='Sandbox_Zdenek/Scene4/4'>structural motif</scene>. | Melanoma associated antigen (MAGE) proteins are associated also with DNA replication processes. This family of proteins contains more than 60 species divided into 6 families. As described in <ref> pmid 20864041</ref> the family is characterised by [[Coiled_coil]] <scene name='Sandbox_Zdenek/Scene4/4'>structural motif</scene>. | ||
Current revision
Structural maintenance of chromosomes protein complexes
| |||||||||||
- ↑ Murray JM, Carr AM. Smc5/6: a link between DNA repair and unidirectional replication? Nat Rev Mol Cell Biol. 2008 Feb;9(2):177-82. PMID:18059412 doi:10.1038/nrm2309
- ↑ De Piccoli G, Torres-Rosell J, Aragon L. The unnamed complex: what do we know about Smc5-Smc6? Chromosome Res. 2009;17(2):251-63. PMID:19308705 doi:10.1007/s10577-008-9016-8
- ↑ Lehmann AR. The role of SMC proteins in the responses to DNA damage. DNA Repair (Amst). 2005 Mar 2;4(3):309-14. PMID:15661654 doi:10.1016/j.dnarep.2004.07.009
- ↑ Lehmann AR, Walicka M, Griffiths DJ, Murray JM, Watts FZ, McCready S, Carr AM. The rad18 gene of Schizosaccharomyces pombe defines a new subgroup of the SMC superfamily involved in DNA repair. Mol Cell Biol. 1995 Dec;15(12):7067-80. PMID:8524274
- ↑ Fousteri MI, Lehmann AR. A novel SMC protein complex in Schizosaccharomyces pombe contains the Rad18 DNA repair protein. EMBO J. 2000 Apr 3;19(7):1691-702. PMID:10747036 doi:10.1093/emboj/19.7.1691
- ↑ Doyle JM, Gao J, Wang J, Yang M, Potts PR. MAGE-RING protein complexes comprise a family of E3 ubiquitin ligases. Mol Cell. 2010 Sep 24;39(6):963-74. PMID:20864041 doi:10.1016/j.molcel.2010.08.029
