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3e0b
From Proteopedia
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| - | [[Image:3e0b.png|left|200px]] | ||
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{{STRUCTURE_3e0b| PDB=3e0b | SCENE= }} | {{STRUCTURE_3e0b| PDB=3e0b | SCENE= }} | ||
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===Bacillus anthracis Dihydrofolate Reductase complexed with NADPH and 2,4-diamino-5-(3-(2,5-dimethoxyphenyl)prop-1-ynyl)-6-ethylpyrimidine (UCP120B)=== | ===Bacillus anthracis Dihydrofolate Reductase complexed with NADPH and 2,4-diamino-5-(3-(2,5-dimethoxyphenyl)prop-1-ynyl)-6-ethylpyrimidine (UCP120B)=== | ||
| + | {{ABSTRACT_PUBMED_19007108}} | ||
| - | + | ==Function== | |
| + | [[http://www.uniprot.org/uniprot/Q81R22_BACAN Q81R22_BACAN]] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity).[PIRNR:PIRNR000194] | ||
==About this Structure== | ==About this Structure== | ||
| - | [[3e0b]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/ | + | [[3e0b]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_cereus_var._anthracis"_(cohn_1872)_smith_et_al._1946 "bacillus cereus var. anthracis" (cohn 1872) smith et al. 1946]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3E0B OCA]. |
==See Also== | ==See Also== | ||
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==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID:019007108</ref><references group="xtra"/> | + | <ref group="xtra">PMID:019007108</ref><references group="xtra"/><references/> |
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[[Category: Dihydrofolate reductase]] | [[Category: Dihydrofolate reductase]] | ||
[[Category: Anderson, A C.]] | [[Category: Anderson, A C.]] | ||
Revision as of 12:25, 20 November 2013
Contents |
Bacillus anthracis Dihydrofolate Reductase complexed with NADPH and 2,4-diamino-5-(3-(2,5-dimethoxyphenyl)prop-1-ynyl)-6-ethylpyrimidine (UCP120B)
Template:ABSTRACT PUBMED 19007108
Function
[Q81R22_BACAN] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity).[PIRNR:PIRNR000194]
About this Structure
3e0b is a 2 chain structure with sequence from "bacillus_cereus_var._anthracis"_(cohn_1872)_smith_et_al._1946 "bacillus cereus var. anthracis" (cohn 1872) smith et al. 1946. Full crystallographic information is available from OCA.
See Also
Reference
- Beierlein JM, Frey KM, Bolstad DB, Pelphrey PM, Joska TM, Smith AE, Priestley ND, Wright DL, Anderson AC. Synthetic and Crystallographic Studies of a New Inhibitor Series Targeting Bacillus anthracis Dihydrofolate Reductase. J Med Chem. 2008 Nov 13. PMID:19007108 doi:10.1021/jm800776a
