3bvp

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:3bvp.png|left|200px]]
+
==Crystal Structure of the N-terminal Catalytic Domain of TP901-1 Integrase==
 +
<StructureSection load='3bvp' size='340' side='right' caption='[[3bvp]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
 +
== Structural highlights ==
 +
<table><tr><td colspan='2'>[[3bvp]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lactococcus_phage_tp901-1 Lactococcus phage tp901-1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BVP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3BVP FirstGlance]. <br>
 +
</td></tr><tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">int ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=35345 Lactococcus phage TP901-1])</td></tr>
 +
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3bvp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bvp OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3bvp RCSB], [http://www.ebi.ac.uk/pdbsum/3bvp PDBsum]</span></td></tr>
 +
<table>
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bv/3bvp_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
 +
<div style="clear:both"></div>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
The serine integrases have recently emerged as powerful new chromosome engineering tools in various organisms and show promise for therapeutic use in human cells. The serine integrases are structurally and mechanistically unrelated to the bacteriophage lambda integrase but share a similar catalytic domain with the resolvase/invertase enzymes typified by the resolvase proteins from transposons Tn3 and gammadelta. Here we report the crystal structure and solution properties of the catalytic domain from bacteriophage TP901-1 integrase. The protein is a dimer in solution but crystallizes as a tetramer that is closely related in overall architecture to structures of activated gammadelta-resolvase mutants. The ability of the integrase tetramer to explain biochemical experiments performed in the resolvase and invertase systems suggests that the TP901 integrase tetramer represents a unique intermediate on the recombination pathway that is shared within the serine recombinase superfamily.
-
{{STRUCTURE_3bvp| PDB=3bvp | SCENE= }}
+
Tetrameric structure of a serine integrase catalytic domain.,Yuan P, Gupta K, Van Duyne GD Structure. 2008 Aug 6;16(8):1275-86. PMID:18682229<ref>PMID:18682229</ref>
-
===Crystal Structure of the N-terminal Catalytic Domain of TP901-1 Integrase===
+
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-
 
+
</div>
-
{{ABSTRACT_PUBMED_18682229}}
+
-
 
+
-
==About this Structure==
+
-
[[3bvp]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lactococcus_phage_tp901-1 Lactococcus phage tp901-1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BVP OCA].
+
==See Also==
==See Also==
*[[Phage integrase|Phage integrase]]
*[[Phage integrase|Phage integrase]]
*[[Resolvase|Resolvase]]
*[[Resolvase|Resolvase]]
-
 
+
== References ==
-
==Reference==
+
<references/>
-
<ref group="xtra">PMID:018682229</ref><references group="xtra"/>
+
__TOC__
 +
</StructureSection>
[[Category: Lactococcus phage tp901-1]]
[[Category: Lactococcus phage tp901-1]]
[[Category: Duyne, G D.Van.]]
[[Category: Duyne, G D.Van.]]

Revision as of 06:50, 29 September 2014

Crystal Structure of the N-terminal Catalytic Domain of TP901-1 Integrase

3bvp, resolution 2.10Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3bvp"
Views
Personal tools
Navigation
Toolbox