3fyw

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[[Image:3fyw.png|left|200px]]
 
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{{STRUCTURE_3fyw| PDB=3fyw | SCENE= }}
{{STRUCTURE_3fyw| PDB=3fyw | SCENE= }}
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===Staph. aureus DHFR complexed with NADPH and AR-101===
===Staph. aureus DHFR complexed with NADPH and AR-101===
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{{ABSTRACT_PUBMED_19622858}}
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{{ABSTRACT_PUBMED_19622858}}
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==Function==
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[[http://www.uniprot.org/uniprot/DYR_STAAU DYR_STAAU]] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
==About this Structure==
==About this Structure==
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[[3fyw]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FYW OCA].
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[[3fyw]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"micrococcus_aureus"_(rosenbach_1884)_zopf_1885 "micrococcus aureus" (rosenbach 1884) zopf 1885]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FYW OCA].
==See Also==
==See Also==
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==Reference==
==Reference==
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<ref group="xtra">PMID:019622858</ref><references group="xtra"/>
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<ref group="xtra">PMID:019622858</ref><references group="xtra"/><references/>
[[Category: Dihydrofolate reductase]]
[[Category: Dihydrofolate reductase]]
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[[Category: Staphylococcus aureus]]
 
[[Category: Oefner, C.]]
[[Category: Oefner, C.]]
[[Category: Ar-101]]
[[Category: Ar-101]]

Revision as of 11:45, 20 November 2013

Template:STRUCTURE 3fyw

Contents

Staph. aureus DHFR complexed with NADPH and AR-101

Template:ABSTRACT PUBMED 19622858

Function

[DYR_STAAU] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.

About this Structure

3fyw is a 1 chain structure with sequence from "micrococcus_aureus"_(rosenbach_1884)_zopf_1885 "micrococcus aureus" (rosenbach 1884) zopf 1885. Full crystallographic information is available from OCA.

See Also

Reference

  • Oefner C, Parisi S, Schulz H, Lociuro S, Dale GE. Inhibitory properties and X-ray crystallographic study of the binding of AR-101, AR-102 and iclaprim in ternary complexes with NADPH and dihydrofolate reductase from Staphylococcus aureus. Acta Crystallogr D Biol Crystallogr. 2009 Aug;65(Pt 8):751-7. Epub 2009, Jul 10. PMID:19622858 doi:10.1107/S0907444909013936

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OCA

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