3fq0

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:3fq0.png|left|200px]]
 
- 
{{STRUCTURE_3fq0| PDB=3fq0 | SCENE= }}
{{STRUCTURE_3fq0| PDB=3fq0 | SCENE= }}
- 
===Staphylococcus aureus dihydrofolate reductase complexed with NADPH and 2,4-diamino-5-(3-(2,5-dimethoxyphenyl)prop-1-ynyl)-6-ethylpyrimidine (UCP120B)===
===Staphylococcus aureus dihydrofolate reductase complexed with NADPH and 2,4-diamino-5-(3-(2,5-dimethoxyphenyl)prop-1-ynyl)-6-ethylpyrimidine (UCP120B)===
 +
{{ABSTRACT_PUBMED_19249312}}
-
{{ABSTRACT_PUBMED_19249312}}
+
==Function==
 +
[[http://www.uniprot.org/uniprot/Q2YY41_STAAB Q2YY41_STAAB]] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity).[PIRNR:PIRNR000194]
==About this Structure==
==About this Structure==
-
[[3fq0]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus_rf122 Staphylococcus aureus rf122]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FQ0 OCA].
+
[[3fq0]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Staab Staab]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FQ0 OCA].
==See Also==
==See Also==
Line 14: Line 13:
==Reference==
==Reference==
-
<ref group="xtra">PMID:019249312</ref><references group="xtra"/>
+
<ref group="xtra">PMID:019249312</ref><references group="xtra"/><references/>
[[Category: Dihydrofolate reductase]]
[[Category: Dihydrofolate reductase]]
-
[[Category: Staphylococcus aureus rf122]]
+
[[Category: Staab]]
[[Category: Anderson, A C.]]
[[Category: Anderson, A C.]]
[[Category: Frey, K M.]]
[[Category: Frey, K M.]]

Revision as of 08:33, 27 November 2013

Template:STRUCTURE 3fq0

Contents

Staphylococcus aureus dihydrofolate reductase complexed with NADPH and 2,4-diamino-5-(3-(2,5-dimethoxyphenyl)prop-1-ynyl)-6-ethylpyrimidine (UCP120B)

Template:ABSTRACT PUBMED 19249312

Function

[Q2YY41_STAAB] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity).[PIRNR:PIRNR000194]

About this Structure

3fq0 is a 1 chain structure with sequence from Staab. Full crystallographic information is available from OCA.

See Also

Reference

  • Frey KM, Liu J, Lombardo MN, Bolstad DB, Wright DL, Anderson AC. Crystal structures of wild-type and mutant methicillin-resistant Staphylococcus aureus dihydrofolate reductase reveal an alternate conformation of NADPH that may be linked to trimethoprim resistance. J Mol Biol. 2009 Apr 17;387(5):1298-308. Epub 2009 Feb 26. PMID:19249312 doi:10.1016/j.jmb.2009.02.045

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3fq0"
Personal tools