3fra

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[[Image:3fra.png|left|200px]]
 
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{{STRUCTURE_3fra| PDB=3fra | SCENE= }}
{{STRUCTURE_3fra| PDB=3fra | SCENE= }}
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===Staphylococcus aureus F98Y DHFR complexed with iclaprim===
===Staphylococcus aureus F98Y DHFR complexed with iclaprim===
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{{ABSTRACT_PUBMED_19211577}}
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{{ABSTRACT_PUBMED_19211577}}
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==Function==
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[[http://www.uniprot.org/uniprot/DYR_STAAU DYR_STAAU]] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
==About this Structure==
==About this Structure==
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[[3fra]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FRA OCA].
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[[3fra]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"micrococcus_aureus"_(rosenbach_1884)_zopf_1885 "micrococcus aureus" (rosenbach 1884) zopf 1885]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FRA OCA].
==See Also==
==See Also==
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==Reference==
==Reference==
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<ref group="xtra">PMID:019211577</ref><references group="xtra"/>
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<ref group="xtra">PMID:019211577</ref><references group="xtra"/><references/>
[[Category: Dihydrofolate reductase]]
[[Category: Dihydrofolate reductase]]
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[[Category: Staphylococcus aureus]]
 
[[Category: Dale-Glenn, E.]]
[[Category: Dale-Glenn, E.]]
[[Category: Oefner, C.]]
[[Category: Oefner, C.]]

Revision as of 06:29, 23 April 2014

Template:STRUCTURE 3fra

Contents

Staphylococcus aureus F98Y DHFR complexed with iclaprim

Template:ABSTRACT PUBMED 19211577

Function

[DYR_STAAU] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.

About this Structure

3fra is a 1 chain structure with sequence from "micrococcus_aureus"_(rosenbach_1884)_zopf_1885 "micrococcus aureus" (rosenbach 1884) zopf 1885. Full crystallographic information is available from OCA.

See Also

Reference

  • Oefner C, Bandera M, Haldimann A, Laue H, Schulz H, Mukhija S, Parisi S, Weiss L, Lociuro S, Dale GE. Increased hydrophobic interactions of iclaprim with Staphylococcus aureus dihydrofolate reductase are responsible for the increase in affinity and antibacterial activity. J Antimicrob Chemother. 2009 Apr;63(4):687-98. Epub 2009 Feb 11. PMID:19211577 doi:10.1093/jac/dkp024

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