This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
3td8
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| - | [[Image:3td8.png|left|200px]] | ||
| - | |||
{{STRUCTURE_3td8| PDB=3td8 | SCENE= }} | {{STRUCTURE_3td8| PDB=3td8 | SCENE= }} | ||
| - | |||
===Structural Analysis of Pneumocystis carinii Dihydrofolate Reductase Complex with NADPH and 2,4-diamino-5-methyl-6-[2'-(4-carboxy-1-pentynyl)-5'-methoxybenzyl]pyrido[2,3-d]pyrimidine=== | ===Structural Analysis of Pneumocystis carinii Dihydrofolate Reductase Complex with NADPH and 2,4-diamino-5-methyl-6-[2'-(4-carboxy-1-pentynyl)-5'-methoxybenzyl]pyrido[2,3-d]pyrimidine=== | ||
| + | {{ABSTRACT_PUBMED_22505410}} | ||
| - | + | ==Function== | |
| + | [[http://www.uniprot.org/uniprot/DYR_PNECA DYR_PNECA]] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | ||
==About this Structure== | ==About this Structure== | ||
| - | [[3td8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/ | + | [[3td8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Pneca Pneca]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TD8 OCA]. |
==See Also== | ==See Also== | ||
| Line 14: | Line 13: | ||
==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID:022505410</ref><references group="xtra"/> | + | <ref group="xtra">PMID:022505410</ref><references group="xtra"/><references/> |
[[Category: Dihydrofolate reductase]] | [[Category: Dihydrofolate reductase]] | ||
| - | [[Category: | + | [[Category: Pneca]] |
[[Category: Cody, V.]] | [[Category: Cody, V.]] | ||
[[Category: Pace, J.]] | [[Category: Pace, J.]] | ||
Revision as of 12:17, 20 November 2013
Contents |
Structural Analysis of Pneumocystis carinii Dihydrofolate Reductase Complex with NADPH and 2,4-diamino-5-methyl-6-[2'-(4-carboxy-1-pentynyl)-5'-methoxybenzyl]pyrido[2,3-d]pyrimidine
Template:ABSTRACT PUBMED 22505410
Function
[DYR_PNECA] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
About this Structure
3td8 is a 1 chain structure with sequence from Pneca. Full crystallographic information is available from OCA.
See Also
Reference
- Cody V, Pace J, Stewart E. Structural analysis of Pneumocystis cariniidihydrofolate reductase complexed with NADPH and 2,4-diamino-6-[2-(5-carboxypent-1-yn-1-yl)-5-methoxybenzyl]-5-methylpyrido[2,3-d] pyrimidine. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012 Apr 1;68(Pt 4):418-23., Epub 2012 Mar 28. PMID:22505410 doi:10.1107/S1744309112008688
