Fibrin
From Proteopedia
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[[Image:1n73b.png|left|250px|thumb|Crystal Structure of Fibrin from ''Petromyzon marinus'', [[1n73]]]] | [[Image:1n73b.png|left|250px|thumb|Crystal Structure of Fibrin from ''Petromyzon marinus'', [[1n73]]]] | ||
| - | {{STRUCTURE_1n73| PDB=1n73 | SIZE=400| SCENE=Fibrin/Cv/2 |right|CAPTION=Fibrin from ''Petromyzon marinus'', [[1n73]] }} | + | {{STRUCTURE_1n73| PDB=1n73 | SIZE=400| SCENE=Fibrin/Cv/2 |right|CAPTION=Fibrin α1 subunit (red, yellow), β subunit (Green, blue), γ subunit (orange, magenta) from ''Petromyzon marinus'', [[1n73]] }} |
Revision as of 08:15, 31 October 2012
Fibrin (or Factor Ia, FIa) is a fibrous protein which when polymerized is involved in blood clotting. The polymerization epitopes of FIa are called A-knob and B-knob. Fibrinogen (Factor I, FI) is converted by thrombin to fibrin. Limited proteolysis of FI results in a fragment named D which when cross-linked by factor XIII is called double-D FIa (DDFIa). The images at the left and at the right correspond to one representative Fibrin, i.e. the crystal structure of Fibrin from Petromyzon marinus (1n73).
Contents |
3D Structures of Fibrin
3h32 – hFIa peptide+ hFI α, β, γ chains – human
2q9i, 2z4e - hFIa B-knob+ hFI α, β, γ chains
2hlo, 1n86 - hFIa α, β, γ chains + peptide
1n8e - hFIa α, β, γ chains
1n73 - FIa α, β, γ chains + peptide – Sea lamprey
1fzc – hDDFIa+peptide
