3qga
From Proteopedia
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| - | + | ==3.0 A Model of Iron Containing Urease UreA2B2 from Helicobacter mustelae== | |
| - | + | <StructureSection load='3qga' size='340' side='right' caption='[[3qga]], [[Resolution|resolution]] 3.00Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[3qga]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Helicobacter_mustelae Helicobacter mustelae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QGA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3QGA FirstGlance]. <br> | |
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene></td></tr> | ||
| + | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=FME:N-FORMYLMETHIONINE'>FME</scene>, <scene name='pdbligand=KCX:LYSINE+NZ-CARBOXYLIC+ACID'>KCX</scene></td></tr> | ||
| + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3qgk|3qgk]]</td></tr> | ||
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">HMU13020, ureA2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=217 Helicobacter mustelae]), HMU13010, ureB2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=217 Helicobacter mustelae])</td></tr> | ||
| + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Urease Urease], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.1.5 3.5.1.5] </span></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3qga FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qga OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3qga RCSB], [http://www.ebi.ac.uk/pdbsum/3qga PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Helicobacter mustelae, a gastric pathogen of ferrets, synthesizes a distinct iron-dependent urease in addition to its archetypical nickel-containing enzyme. The iron-urease is oxygen-labile, with the inactive protein exhibiting a methemerythrin-like electronic spectrum. Significantly, incubation of the oxidized protein with dithionite under anaerobic conditions leads to restoration of activity and bleaching of the spectrum. Structural analysis of the oxidized species reveals a dinuclear iron metallocenter bridged by a lysine carbamate, closely resembling the traditional nickel-urease active site. Although the iron-urease is less active than the nickel-enzyme, its activity allows H. mustelae to survive the carnivore's low-nickel gastric environment. | ||
| - | + | Iron-containing urease in a pathogenic bacterium.,Carter EL, Tronrud DE, Taber SR, Karplus PA, Hausinger RP Proc Natl Acad Sci U S A. 2011 Jul 25. PMID:21788478<ref>PMID:21788478</ref> | |
| - | + | ||
| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
==See Also== | ==See Also== | ||
*[[Urease|Urease]] | *[[Urease|Urease]] | ||
| - | + | == References == | |
| - | == | + | <references/> |
| - | < | + | __TOC__ |
| + | </StructureSection> | ||
[[Category: Helicobacter mustelae]] | [[Category: Helicobacter mustelae]] | ||
[[Category: Urease]] | [[Category: Urease]] | ||
| - | [[Category: Karplus, P A | + | [[Category: Karplus, P A]] |
| - | [[Category: Robbins, A | + | [[Category: Robbins, A]] |
| - | [[Category: Tronrud, D E | + | [[Category: Tronrud, D E]] |
[[Category: Alpha-beta barrel]] | [[Category: Alpha-beta barrel]] | ||
[[Category: Hydrolase]] | [[Category: Hydrolase]] | ||
[[Category: Iron metalloenzyme]] | [[Category: Iron metalloenzyme]] | ||
| - | [[Category: Urease]] | ||
Revision as of 08:25, 18 December 2014
3.0 A Model of Iron Containing Urease UreA2B2 from Helicobacter mustelae
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