Glucagon
From Proteopedia
(Difference between revisions)
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| - | {{STRUCTURE_1bh0| PDB=1bh0 | SIZE= | + | {{STRUCTURE_1bh0| PDB=1bh0 | SIZE=350| SCENE= |right|CAPTION=Human glucagon, [[1bh0]] }} |
| + | == Function == | ||
| - | '''Glucagon''' (GLC) is a hormone which raises blood glucose level. GLC causes the liver to convert glycogen to glucose. GLC effect is opposite to that of insulin. See some details in [[User:Mary Ball/Glucagon]]. | + | '''Glucagon''' (GLC) is a hormone which raises blood glucose level. GLC causes the liver to convert glycogen to glucose. GLC effect is opposite to that of insulin<ref>PMID:21824265</ref>. See some details in [[User:Mary Ball/Glucagon]]. |
| - | + | == Relevance == | |
| + | |||
| + | Glucagon is injected in cases of severe glycemia<ref>PMID:15793249</ref>. Overdose of β blockers is treated with GLC. Epinephrin-resistant low blood pressure cases are treated with GLC. Pancreatic tumors may cause high levels of GLC. | ||
== 3D Structures of glucagon == | == 3D Structures of glucagon == | ||
Revision as of 10:43, 6 March 2016
Function
Glucagon (GLC) is a hormone which raises blood glucose level. GLC causes the liver to convert glycogen to glucose. GLC effect is opposite to that of insulin[1]. See some details in User:Mary Ball/Glucagon.
Relevance
Glucagon is injected in cases of severe glycemia[2]. Overdose of β blockers is treated with GLC. Epinephrin-resistant low blood pressure cases are treated with GLC. Pancreatic tumors may cause high levels of GLC.
3D Structures of glucagon
Updated on 06-March-2016
2g49 – hGLC preprotein residues 53-81+ insulin-degrading enzyme – human
1kx6, 2m5p, 2m5q – hGLC - NMR
1nau – hGLC (mutant) – NMR
1bh0 - hGLC (mutant)
1gcn - hGLC
