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Glucagon

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{{STRUCTURE_1bh0| PDB=1bh0 | SIZE=400| SCENE= |right|CAPTION=Human glucagon, [[1bh0]] }}
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{{STRUCTURE_1bh0| PDB=1bh0 | SIZE=350| SCENE= |right|CAPTION=Human glucagon, [[1bh0]] }}
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== Function ==
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'''Glucagon''' (GLC) is a hormone which raises blood glucose level. GLC causes the liver to convert glycogen to glucose. GLC effect is opposite to that of insulin. See some details in [[User:Mary Ball/Glucagon]].
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'''Glucagon''' (GLC) is a hormone which raises blood glucose level. GLC causes the liver to convert glycogen to glucose. GLC effect is opposite to that of insulin<ref>PMID:21824265</ref>. See some details in [[User:Mary Ball/Glucagon]].
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== Relevance ==
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Glucagon is injected in cases of severe glycemia<ref>PMID:15793249</ref>. Overdose of β blockers is treated with GLC. Epinephrin-resistant low blood pressure cases are treated with GLC. Pancreatic tumors may cause high levels of GLC.
== 3D Structures of glucagon ==
== 3D Structures of glucagon ==

Revision as of 10:43, 6 March 2016

Template:STRUCTURE 1bh0

Function

Glucagon (GLC) is a hormone which raises blood glucose level. GLC causes the liver to convert glycogen to glucose. GLC effect is opposite to that of insulin[1]. See some details in User:Mary Ball/Glucagon.

Relevance

Glucagon is injected in cases of severe glycemia[2]. Overdose of β blockers is treated with GLC. Epinephrin-resistant low blood pressure cases are treated with GLC. Pancreatic tumors may cause high levels of GLC.

3D Structures of glucagon

Updated on 06-March-2016

2g49 – hGLC preprotein residues 53-81+ insulin-degrading enzyme – human
1kx6, 2m5p, 2m5q – hGLC - NMR
1nau – hGLC (mutant) – NMR
1bh0 - hGLC (mutant)
1gcn - hGLC

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Karsten Theis, Ann Taylor

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