Cell death protein
From Proteopedia
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[[3qwx]], [[3qwy]] - CeCED-2 – ''Caenorhabditis elegans'' | [[3qwx]], [[3qwy]] - CeCED-2 – ''Caenorhabditis elegans'' | ||
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| + | ===CED-3=== | ||
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| + | [[4m9r]] - nCED-3 - nematode<br /> | ||
===CED-4=== | ===CED-4=== | ||
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[[2hm8]] - mCED-4 MA3 domain – NMR<BR /> | [[2hm8]] - mCED-4 MA3 domain – NMR<BR /> | ||
[[3eij]] - hCED-4 residues 157-469<BR /> | [[3eij]] - hCED-4 residues 157-469<BR /> | ||
| - | [[2zu6]], [[3eiq]] - hCED-4 residues 163-469 + eukaryotic initiation factor 4A-I | + | [[2zu6]], [[3eiq]] - hCED-4 residues 163-469 + eukaryotic initiation factor 4A-I<br /> |
| + | [[4m9s]], [[4m9x]], [[4m9y]], [[4m9z]] - nCED-4 + nCED-3 fragment<br /> | ||
===CED-5=== | ===CED-5=== | ||
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===CED-6=== | ===CED-6=== | ||
| - | [[1y1x]] - CED-6 – ''Leishmania major'' | + | [[1y1x]] - CED-6 – ''Leishmania major''<br /> |
| + | [[1hqv]] - mCED-6<br /> | ||
| + | [[2zn8]], [[2zn9]], [[2znd]], [[2zrs]], [[2zrt]] - hCED-6<br /> | ||
| + | [[3aaj]], [[3aak]] - hCED-6 (mutant)<br /> | ||
| + | [[2zne]] - hCED-6 + CED-6-interacting protein<br /> | ||
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| + | ===CED-8=== | ||
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| + | [[1gv4]] - mCED-8<br /> | ||
| + | [[1m6i]] - hCED-8<br /> | ||
===CED-9=== | ===CED-9=== | ||
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===CED-10=== | ===CED-10=== | ||
| - | [[3ajm]] - hCED-10 + inositol tetrakisphosphate | + | [[3ajm]] - hCED-10 + inositol tetrakisphosphate<br /> |
| + | [[3l8i]], [[3l8j]] - hCED-10<br /> | ||
| + | [[3rqe]], [[3rqf]], [[3rqg]] - hCED-10 + paxillidin peptide<br /> | ||
| + | [[3w8h]], [[3w8i]], [[4geh]] - hCED-10 + serine/threonine kinase regulatory domain<br /> | ||
===CED-HAC-1=== | ===CED-HAC-1=== | ||
[[1vt4]], [[3iz8]] – CED-HAC-1 – ''Drosophila melanogaster'' | [[1vt4]], [[3iz8]] – CED-HAC-1 – ''Drosophila melanogaster'' | ||
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[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 10:32, 18 February 2014
Cell death proteins or Programmed cell death protein or CD279 (CED) are involved in the process of cellular apoptosis. CED-1 is a T cell regulator. CED-1 is expressed on the surface of T cells, B cells and macrophages. It is a membrane protein and acts in suppressing the immune system during pregnancy, tissue allografts, autoimmune diseases and hepatitis. CED-1 has 2 ligands: CED-L1 and CED-L2. Formation of CED-1/CED-L1 complex reduces T cell proliferation at the lymph nodes. For details on CED-4 see CED-4 Apoptosome.
3D structures of cell death protein
Updated on 18-February-2014
CED-1
1npu – mCED-1 extracellular domain (mutant) - mouse
3rrq - hCED-1 extracellular domain (mutant) - human
2m2d - hCED-1 extracellular domain - NMR
3bik - mCED-1 extracellular domain (mutant) + hCED-L1 extracellular domain
3sbw - mCED-1 extracellular domain + hCED-L1 extracellular domain
3rnq - mCED-1 extracellular domain + mCED-L2 extracellular domain
3bp5, 3bp6 - mCED-1 extracellular domain (mutant) + mCED-L2 extracellular domain
3rnk - mCED-1 extracellular domain (mutant) + mCED-L2 IgV domain
CED-2
3qwx, 3qwy - CeCED-2 – Caenorhabditis elegans
CED-3
4m9r - nCED-3 - nematode
CED-4
2a5y - CeCED-4 + CeCED-9
3lqq, 3lqr - CeCED-4
2ggf – hCED-4 MA3 domain – NMR
2rg8, 2kzt - hCED-4 MA3 domain
2iol, 2ion, 2ios, 2nsz - mCED-4 MA3 domain
2hm8 - mCED-4 MA3 domain – NMR
3eij - hCED-4 residues 157-469
2zu6, 3eiq - hCED-4 residues 163-469 + eukaryotic initiation factor 4A-I
4m9s, 4m9x, 4m9y, 4m9z - nCED-4 + nCED-3 fragment
CED-5
1yyb - hCED-5 N terminal – NMR
2cru, 2k6b - hCED-5 – NMR
CED-6
1y1x - CED-6 – Leishmania major
1hqv - mCED-6
2zn8, 2zn9, 2znd, 2zrs, 2zrt - hCED-6
3aaj, 3aak - hCED-6 (mutant)
2zne - hCED-6 + CED-6-interacting protein
CED-8
CED-9
1ohu – CeCED-9
1ty4 - CeCED-9 + programmed CED activator
CED-10
3ajm - hCED-10 + inositol tetrakisphosphate
3l8i, 3l8j - hCED-10
3rqe, 3rqf, 3rqg - hCED-10 + paxillidin peptide
3w8h, 3w8i, 4geh - hCED-10 + serine/threonine kinase regulatory domain
