4ke2
From Proteopedia
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| - | + | ==Crystal structure of the hyperactive Type I antifreeze from winter flounder== | |
| - | + | <StructureSection load='4ke2' size='340' side='right' caption='[[4ke2]], [[Resolution|resolution]] 1.80Å' scene=''> | |
| - | + | == Structural highlights == | |
| + | <table><tr><td colspan='2'>[[4ke2]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseam Pseam]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KE2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4KE2 FirstGlance]. <br> | ||
| + | </td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ke2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ke2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ke2 RCSB], [http://www.ebi.ac.uk/pdbsum/4ke2 PDBsum]</span></td></tr> | ||
| + | <table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | When polypeptide chains fold into a protein, hydrophobic groups are compacted in the center with exclusion of water. We report the crystal structure of an alanine-rich antifreeze protein that retains ~400 waters in its core. The putative ice-binding residues of this dimeric, four-helix bundle protein point inwards and coordinate the interior waters into two intersecting polypentagonal networks. The bundle makes minimal protein contacts between helices, but is stabilized by anchoring to the semi-clathrate water monolayers through backbone carbonyl groups in the protein interior. The ordered waters extend outwards to the protein surface and likely are involved in ice binding. This protein fold supports both the anchored-clathrate water mechanism of antifreeze protein adsorption to ice and the water-expulsion mechanism of protein folding. | ||
| - | + | An antifreeze protein folds with an interior network of more than 400 semi-clathrate waters.,Sun T, Lin FH, Campbell RL, Allingham JS, Davies PL Science. 2014 Feb 14;343(6172):795-8. doi: 10.1126/science.1247407. PMID:24531972<ref>PMID:24531972</ref> | |
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| - | == | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> |
| - | + | </div> | |
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Pseam]] | ||
[[Category: Allingham, J S.]] | [[Category: Allingham, J S.]] | ||
[[Category: Campbell, R L.]] | [[Category: Campbell, R L.]] | ||
Revision as of 07:14, 24 September 2014
Crystal structure of the hyperactive Type I antifreeze from winter flounder
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