Rhomboid protease

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'''Rhomboid protease''' is a transmembranal serine protease. The active site is buried in the lipid bilayer of cell membrane. It cleaves proteins within their transmembrane domain. Rhomboids regulate many cellular processes and are involved in many human diseases. The catalytic site of rhomboids contains a hydrophilic pocket protected by from the lipid bilayer. Rhomboids are specific for a single transmembranal helix proteins.
'''Rhomboid protease''' is a transmembranal serine protease. The active site is buried in the lipid bilayer of cell membrane. It cleaves proteins within their transmembrane domain. Rhomboids regulate many cellular processes and are involved in many human diseases. The catalytic site of rhomboids contains a hydrophilic pocket protected by from the lipid bilayer. Rhomboids are specific for a single transmembranal helix proteins.
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</StructureSection>
== 3D Structures of rhomboid protease ==
== 3D Structures of rhomboid protease ==
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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{{#tree:id=OrganizedByTopic|openlevels=0|
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===GlpG===
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*Rhomboid protease
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[[2ic8]], [[2irv]], [[2nrf]], [[2o7l]], [[3b45]], [[2xov]], [[4njn]], [[4njp]] – EcGlpG core region – ''Escherichia coli '' <BR />
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**[[2ic8]], [[2irv]], [[2nrf]], [[2o7l]], [[3b45]], [[2xov]], [[4njn]], [[4njp]] – EcGlpG core region – ''Escherichia coli '' <BR />
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[[2xtu]], [[3b44]], [[2xtv]] – EcGlpG core region (mutant) <BR />
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**[[2xtu]], [[3b44]], [[2xtv]] – EcGlpG core region (mutant) <BR />
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[[4hdd]] – EcGlpG N terminal <BR />
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**[[4hdd]] – EcGlpG N terminal <BR />
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[[2lep]] – EcGlpG N terminal - NMR <BR />
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**[[2lep]] – EcGlpG N terminal - NMR <BR />
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[[2nr9]], [[3odj]] – HiGlpG - ''Haemophilus influenzae '' <BR />
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**[[3odj]] – HiGlpG - ''Haemophilus influenzae '' <BR />
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[[2nr9]] – HiGlpG (mutant) + detergent <BR />
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**[[2nr9]] – HiGlpG (mutant) + detergent <BR />
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[[2gqc]] – RP N terminal – NMR – ''Pseudomonas aeruginosa''<br />
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**[[2gqc]] – RP N terminal – NMR – ''Pseudomonas aeruginosa''<br />
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===GlgG complex with inhibitor===
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*Rhomboid protease complex with inhibitor
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[[2xow]], [[3zeb]] – EcGlpG core region + isocoumarin inhibitor <BR />
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**[[2xow]], [[3zeb]] – EcGlpG core region + isocoumarin inhibitor <BR />
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[[3txt]], [[4h1d]] – EcGlpG core region + DFP inhibitor <BR />
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**[[3txt]], [[4h1d]] – EcGlpG core region + DFP inhibitor <BR />
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[[3ubb]] – EcGlpG core region + phosphonofluoridate inhibitor <BR />
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**[[3ubb]] – EcGlpG core region + phosphonofluoridate inhibitor <BR />
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[[3zmh]], [[3zmi]], [[3zmhj], [[3zot]], [[3zmj]] – EcGlpG core region + β-lactam inhibitor <BR />
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**[[3zmh]], [[3zmi]], [[3zmhj], [[3zot]], [[3zmj]] – EcGlpG core region + β-lactam inhibitor <BR />
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}}
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 11:30, 7 December 2014

Structure of rhomboid protease complex with inhibitor DFP (PDB entry 4h1d)

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3D Structures of rhomboid protease

Updated on 07-December-2014 {{#tree:id=OrganizedByTopic|openlevels=0|

  • Rhomboid protease
    • 2ic8, 2irv, 2nrf, 2o7l, 3b45, 2xov, 4njn, 4njp – EcGlpG core region – Escherichia coli
    • 2xtu, 3b44, 2xtv – EcGlpG core region (mutant)
    • 4hdd – EcGlpG N terminal
    • 2lep – EcGlpG N terminal - NMR
    • 3odj – HiGlpG - Haemophilus influenzae
    • 2nr9 – HiGlpG (mutant) + detergent
    • 2gqc – RP N terminal – NMR – Pseudomonas aeruginosa
  • Rhomboid protease complex with inhibitor
    • 2xow, 3zeb – EcGlpG core region + isocoumarin inhibitor
    • 3txt, 4h1d – EcGlpG core region + DFP inhibitor
    • 3ubb – EcGlpG core region + phosphonofluoridate inhibitor
    • 3zmh, 3zmi, [[3zmhj], 3zot, 3zmj – EcGlpG core region + β-lactam inhibitor

}}

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Michal Harel, Alexander Berchansky, Joel L. Sussman

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