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Sandbox Reserved 930

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==Introduction==
==Introduction==
[[Image:Actin myosin anim.gif|400px|left|thumb| Figure 1. The movement of myosin motor domain on actin filament]]
[[Image:Actin myosin anim.gif|400px|left|thumb| Figure 1. The movement of myosin motor domain on actin filament]]
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[[Image:myosin.png‎|450px|right|thumb| Figure 2. The contractile cycle of the myosin head]]
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[[Image:myosin.png‎|450px|right|thumb| Figure 2. The contractile cycle of the myosin head]] <references>
In the striated muscle the actin and myosin proteins form ordered basic units called sarcomeres. Muscle contraction is achieved by the mechanical sliding of myosin filament (thick filament) along the actin filament (thin filament), Fig. 1. The major constituent of the myosin filament is myosin, a motor protein responsible for converting chemical energy to mechanical movement. In the presence of Ca<sup>2+</sup> and Mg<sup>2+</sup>, myosin is able to cyclically bind ATP and hydrolyse it to ADP + P<sub>i</sub> , triggering subsequent myosin-actin detachment, reattachment and power stroke, so called contractile reaction (Fig.2).
In the striated muscle the actin and myosin proteins form ordered basic units called sarcomeres. Muscle contraction is achieved by the mechanical sliding of myosin filament (thick filament) along the actin filament (thin filament), Fig. 1. The major constituent of the myosin filament is myosin, a motor protein responsible for converting chemical energy to mechanical movement. In the presence of Ca<sup>2+</sup> and Mg<sup>2+</sup>, myosin is able to cyclically bind ATP and hydrolyse it to ADP + P<sub>i</sub> , triggering subsequent myosin-actin detachment, reattachment and power stroke, so called contractile reaction (Fig.2).

Revision as of 12:10, 16 May 2014

This Sandbox is Reserved from 01/04/2014, through 30/06/2014 for use in the course "510042. Protein structure, function and folding" taught by Prof Adrian Goldman, Tommi Kajander, Taru Meri, Konstantin Kogan and Juho Kellosalo at the University of Helsinki. This reservation includes Sandbox Reserved 923 through Sandbox Reserved 947.
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Scallop myosin head in its pre power stroke state

Introduction

Figure 1. The movement of myosin motor domain on actin filament
Figure 1. The movement of myosin motor domain on actin filament
Figure 2. The contractile cycle of the myosin head
Figure 2. The contractile cycle of the myosin head
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