Chaperonin

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[[3ruw]] - MmCPN (mutant) + ADP-AlF3<br />
[[3ruw]] - MmCPN (mutant) + ADP-AlF3<br />
[[3ruv]] - MmCPN (mutant) + ATP analog<br />
[[3ruv]] - MmCPN (mutant) + ATP analog<br />
-
[[1q2v]], [[1q3r]] – TkCPN α subunit (mutant) – ''Thermococcus'' KS-1<BR />
 
-
[[1q3q]] - TkCPN α subunit (mutant) + AMP-PNP<BR />
 
-
[[1q3s]] - TkCPN α subunit (mutant) + ADP
 
===CCT===
===CCT===
-
[[2xsm]] – bCPN CCT – bovine<BR />
+
[[2xsm]], [[4b2t]] – bCPN CCT – bovine<BR />
-
[[3p9d]], [[3p9e]], [[4d8q]], [[4d8r]] – CPN CCT - yeast<br />
+
[[3p9d]], [[3p9e]], [[4d8q]], [[4d8r]], [[4aol]], [[4apk]] – CPN CCT - yeast<br />
-
[[3iyg]] - bCPN CCT – Cryo EM<BR />
+
[[3iyg]], [[4a0o]] - bCPN CCT – Cryo EM<BR />
 +
[[4a0v]] - bCPN CCT + AMPPNP – Cryo EM<br />
 +
[[4a0w]] - bCPN CCT + ADP + AlF3 – Cryo EM<br />
 +
[[4a13]] - bCPN CCT + ADP – Cryo EM<br />
[[3ktt]] - bCPN CCT β subunit – Cryo EM<BR />
[[3ktt]] - bCPN CCT β subunit – Cryo EM<BR />
[[1gml]], [[1gn1]] - CPN CCT γ subunit apical domain – mouse
[[1gml]], [[1gn1]] - CPN CCT γ subunit apical domain – mouse
Line 102: Line 102:
===Hsp33===
===Hsp33===
-
[[3m7m]], [[1hw7]] – EcCPN Hsp33 N-terminal<BR />
+
See [[Heat Shock Proteins]]
-
[[1xjh]] - EcCPN Hsp33 C terminal - NMR<BR />
+
-
[[1vq0]] - CPN Hsp33 – ''Thermotoga maritima''<BR />
+
-
[[1vzy]] - CPN Hsp33 (mutant) – ''Bacillus subtilis''
+
===Thermosome===
===Thermosome===
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[[3j1f]] - AtTherm β subunit + ATP – Cryo EM <br />
[[3j1f]] - AtTherm β subunit + ATP – Cryo EM <br />
[[3aq1]] – Therm – ''Methanococcoides burtonii''<br />
[[3aq1]] – Therm – ''Methanococcoides burtonii''<br />
 +
[[1q2v]], [[1q3r]] – TkTherm α subunit (mutant) – Thermococcus KS-1<br />
 +
[[1q3q]] - TkTherm α subunit (mutant) + AMP-PNP<br />
 +
[[1q3s]] - TkTherm α subunit (mutant) + ADP<br />
 +
[[1lep]] – CPN-10 – ''Mycobacterium leprae''
[[1lep]] – CPN-10 – ''Mycobacterium leprae''
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 07:23, 26 August 2014

Crystal Structure of Chaperonin, 1pcq
Crystal Structure of Chaperonin, 1pcq

Template:STRUCTURE 1pcq













Chaperonins (CPN) are oligomeric proteins that mediate the folding of polypeptide chains. Group I CPN are found in bacteria, chloroplasts and mitochondria. For an introductory overview, see Chaperonins in Wikipedia.

The most characterized CPN are in the GroEL/GroES complex from Escherichia coli and CPN60/CPN10 from Thermus thermophilus. The larger subunit (GroEL, CPN60) contains 3 domains. The apical domain is the one which binds the substrate. Group II CPNs are found in eukaryotic cytosol and archaea. Thermosome is a CPN complex found in archaea. CCT is a CPN complex found in eukarya.

Contents

3D Structures of Chaperonin

Updated on 26-August-2014

Group I

Large subunit

3m6c – MtGroEL1 apical domain – Mycobacterium tuberculosis
1sjp, 3rtk – MtGroEL2 residues 42-539
3fbh, 2eu1, 1j4z, 1kpo, 1oel, 1grl, 2yey – EcGroEL (mutant) - Escherichia coli
3e76, 2nwc, 1xck, 1ss8, 4hel – EcGroEL
3c9v, 3cau, 2ynj – EcGroEL – Cryo EM
2c7e, 1gr5, 4aaq - EcGroEL (mutant) – Cryo EM
1dk7 - EcGroEL apical domain
1fy9, 1fya, 1kid, 1jon, 3vz6, 3vz7, 3vz8 – EcGroEL apical domain (mutant)
1srv – TtCPN60 apical domain - Thermus thermophilus
3osx - CPN60 apical domain – Xenorhabdus nematophila
1iok – CPN60 – Paracoccus denitrificans

Large subunit binary complex

1kp8 - EcGroEL (mutant) + ATP
4aar, 4aas, 4aau, 4ab2, 4ab3 - EcGroEL (mutant) + ATP – Cryo EM
1sx3 - EcGroEL + ATP
1sx4 - EcGroEL + ADP
4ki8 - EcGroEL (mutant) + ADP
1mnf – EcGroEL + polypeptide
2cgt – EcGroEL + capsid assbly protein GP31 – EM
1dkd - EcGroEL apical domain + polypeptide

Small subunit

3nx6 – GroES residues 40-134 (mutant) – Xanthomonas oryzae
1wnr – TtCPN10 residues 1-94
1p3h, 1hx5 – MtCPN10
1p82, 1p83 - MtCPN10 residues 1-25 - NMR
1egs - GroES residues 19-27 - NMR

Large + small subunit

1svt, 1pcq - EcGroEL + GroES
1pf9, 1aon - EcGroEL + GroES + ADP
2c7c, 2c7d - EcGroEL + GroES – Cryo EM
1gru - EcGroEL + GroES + ATP + ADP – Cryo EM
3zpz, 3zq0, 3zq1 - EcGroEL + GroES + ADP – Cryo EM
1we3 – TtCPN60 + CPN10
1wf4 - TtCPN60 + CPN10 + ADP

Group II

3izh, 3izi, 3izj, 3izk, 3izl, 3izm, 3izn, 3los, 3iyf, 3j3x – MmCPN – Methanococcus maripaludis – EM
3kfb, 3kfe, 3kfk – MmCPN
3j02, 3j03 – MmCPN (mutant) – Cryo EM
3ruq - MmCPN + ADP
3rus - MmCPN (mutant) + ADP
3ruw - MmCPN (mutant) + ADP-AlF3
3ruv - MmCPN (mutant) + ATP analog

CCT

2xsm, 4b2t – bCPN CCT – bovine
3p9d, 3p9e, 4d8q, 4d8r, 4aol, 4apk – CPN CCT - yeast
3iyg, 4a0o - bCPN CCT – Cryo EM
4a0v - bCPN CCT + AMPPNP – Cryo EM
4a0w - bCPN CCT + ADP + AlF3 – Cryo EM
4a13 - bCPN CCT + ADP – Cryo EM
3ktt - bCPN CCT β subunit – Cryo EM
1gml, 1gn1 - CPN CCT γ subunit apical domain – mouse

Hsp33

See Heat Shock Proteins

Thermosome

1a6d - TaTherm α+β subunits – Thermoplasma acidophilum
1a6e - TaTherm α+β subunits + ADP
1ass, 1asx - TaTherm α apical domain
1e0r – TaTherm β apical domain
3ko1 – AtTherm α subunit– Acidianus tengchongensis
3j1b, 3j1c, 3j1e - AtTherm α subunit – Cryo EM
3j1f - AtTherm β subunit + ATP – Cryo EM
3aq1 – Therm – Methanococcoides burtonii
1q2v, 1q3r – TkTherm α subunit (mutant) – Thermococcus KS-1
1q3q - TkTherm α subunit (mutant) + AMP-PNP
1q3s - TkTherm α subunit (mutant) + ADP

1lep – CPN-10 – Mycobacterium leprae

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