Dipeptidyl peptidase

(Difference between revisions)

Revision as of 10:44, 17 August 2014

Crystal Structure of Dipeptidyl peptidase (1jqp)

Dipeptidyl peptidase (DPP) is an enzyme which cleaves dipeptides from polypeptides.

DPP-I is involved in inflammatory diseases.
DPP-II is a serine protease.
DPP-III acts similarly to DPP-IV.
DPP-IV (or CD26) cleaves proline dipeptides from the N-termini and is associated with immune regulation.

The images at the left and at the right correspond to one representative DPP, i.e. the crystal structure of Dipeptidyl peptidase-I from rat (1jqp). See also Dipeptidyl Peptidase-4 Inhibitor Pharmacokinetics.

Updated on 17-August-2014

1jqp – rDPP-I – rat
1k3b, 2djg - hDPP-I – human
3pdf, 2djf – hDPP-I + inhibitor

3n0t – hDPP-II peptidase domain residues 28-492+inhibitor
3jyh, 4ebb – hDPP-II peptidase domain residues 28-492

3fvy – hDPP-III
3t6b, 3t6j - hDPP-III (mutant) + tynorphin
3csk – DPP-III (mutant) – yeast

2onc, 1tk3, 1r9m, 1j2e, 1nu6, 1pfq – hDPP-IV extracellular domain
1u8e – hDPP-IV extracellular domain (mutant)
3kwj, 3oc0, 3kwf, 3q8w – hDPP-IV extracellular domain +quinoline derivative
3g0b, 3g0d, 3g0g, 3nox, 3hab, 3hac, 3f8s, 3h0c, 3ccb, 3ccc, 2qjr, 2qky, 3d4l, 2jid, 3bjm, 2rip, 2ole, 2rgu, 2i78, 2oag, 2oqv, 2oqi, 2ogz, 2i03, 2g5p, 2g5t, 2g63, 2bub, 2ajl, 1wcy, 1rwq, 1tkr, 1n1m, 3eio, 3g0c, 3opm, 3sww, 3sx4, 3q0t, 4a5s, 3vjk, 3vjl, 3vjm, 3w2t, 4dsa, 4dsz, 4dtc, 4g1f,3o95, 3o9v, 4j3j, 4jh0, 4lko, 4n8d, 4n8e – hDPP-IV extracellular domain+inhibitor
1r9n, 2bgr, 1nu8 – hDPP-IV extracellular domain+polypeptide
1w1i – hDPP-IV extracellular domain+adenosine deaminase
2bgn – hDPP-IV extracellular domain+adenosine deaminase+polypeptide
3c43, 3c45, 2qoe, 2qt9, 2qtb, 2p8s, 2oph, 2fjp, 1x70, 2iit, 2iiv, 3qbj – hDPP-IV extracellular domain (mutant) + inhibitor
4kr0 - hDPP-IV extracellular domain + S protein
4l72 – rDPP-IV + Mers-Cov Rbd
2gbc – rDPP-IV extracellular domain
2oae, 2i3z, 2gbf, 2gbg, 2gbi – rDPP-IV extracellular domain+inhibitor
4ffv, 4ffw – rDPP-IV + antibody
2aj8, 2ajb, 2ajc, 2ajd, 2bua, 2buc, 1orw – pDPP-IV extracellular domain+inhibitor - pig
1orv - pDPP-IV extracellular domain
2ecf - DPP-IV – Stenotrophomonas maltophilia

3pvq – DPP-VI – Bacterioides thetaiotamicron

@@ Line 28: / Line 28: @@
 *  '''DPP-III''' acts similarly to DPP-IV.<br />
 *  '''DPP-IV''' (or '''CD26''') cleaves proline dipeptides from the N-termini and is associated with immune regulation.<br />
- The images at the left and at the right correspond to one representative DPP, ''i.e.'' the crystal structure of Dipeptidyl peptidase-I from rat ([[1jqp]]).  See also [[Dipeptidyl Peptidase-4 Inhibitor Pharmacokinetics]].
+The images at the left and at the right correspond to one representative DPP, ''i.e.'' the crystal structure of Dipeptidyl peptidase-I from rat ([[1jqp]]).  See also [[Dipeptidyl Peptidase-4 Inhibitor Pharmacokinetics]].