Helicase

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<StructureSection load='1pjr' size='450' side='right' scene='' caption='DNA-dependent helicase PcrA (PDB code [[1pjr]])'>
<StructureSection load='1pjr' size='450' side='right' scene='' caption='DNA-dependent helicase PcrA (PDB code [[1pjr]])'>
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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{{#tree:id=OrganizedByTopic|openlevels=0|
 +
 +
*Helicase Mot1
 +
 +
**[[3oc3]] – Hel MOT1 heat domain + TFIID-1 – ''Encephalitozoon cuniculi''<BR />
-
[[3oc3]] – Hel MOT1 heat domain + TFIID-1 – ''Encephalitozoon cuniculi''<BR />
+
*Helicase 308
-
[[2p6r]] – AfHel 308 + DNA – ''Archaeoglobus fulgidus''<BR />
+
-
[[2p6u]] - AfHel 308
+
-
===DNA helicase===
+
**[[2p6r]] – AfHel 308 + DNA – ''Archaeoglobus fulgidus''<BR />
 +
**[[2p6u]] - AfHel 308
-
[[3lfu]] – EcHel II – ''Escherichia coli''<BR />
+
*DNA helicase
-
[[2is1]], [[2is2]] - EcHel II (mutant) + DNA<BR />
+
-
[[2is4]], [[2is6]] - EcHel II (mutant) + ADP + DNA<BR />
+
-
[[3fld]] – EcHel I C terminal<BR />
+
-
[[4l0j]] – EcHel I translocation domain<br />
+
-
[[2q7t]], [[2q7u]] – EcHel I relaxase domain (mutant) <BR />
+
-
[[1p4d]] - EcHel I relaxase domain<BR />
+
-
[[2a0i]] - EcHel I (mutant) + DNA<BR />
+
-
[[1q2z]], [[1rw2]] – hHel II KU86 C terminal – NMR<BR />
+
-
[[4c2t]], [[4c2u]], [[4c30]] – DrHel II + DNA - ''Deinococcus radiodurans''<br />
+
-
[[1e0j]], [[1e0k]] – Hel 4D domain – Phage T7
+
-
===ATP-dependent helicase ATRX===
+
**[[3lfu]] – EcHel II – ''Escherichia coli''<BR />
 +
**[[2is1]], [[2is2]] - EcHel II (mutant) + DNA<BR />
 +
**[[2is4]], [[2is6]] - EcHel II (mutant) + ADP + DNA<BR />
 +
**[[3fld]] – EcHel I C terminal<BR />
 +
**[[4l0j]] – EcHel I translocation domain<br />
 +
**[[2q7t]], [[2q7u]] – EcHel I relaxase domain (mutant) <BR />
 +
**[[1p4d]] - EcHel I relaxase domain<BR />
 +
**[[2a0i]] - EcHel I (mutant) + DNA<BR />
 +
**[[1q2z]], [[1rw2]] – hHel II KU86 C terminal – NMR<BR />
 +
**[[4c2t]], [[4c2u]], [[4c30]] – DrHel II + DNA - ''Deinococcus radiodurans''<br />
 +
**[[1e0j]], [[1e0k]] – Hel 4D domain – Phage T7
-
[[3qln]] - hATRX ADD domain – human<BR />
+
*ATP-dependent helicase ATRX
-
[[2ld1]], [[2jm1]] - hATRX ADD domain - NMR<BR />
+
-
[[3ql9]] – hATRX ADD domain + histone H3 peptide <BR />
+
-
[[2lbm]] - hATRX ADD domain + histone H3 peptide – NMR<BR />
+
-
[[3qla]], [[3qlc]] - hATRX ADD domain (mutant) + histone H3 peptide<BR />
+
-
[[2xzp]] - hRENT1 helicase domain<BR />
+
-
[[2wjv]] - hRENT1 helicase CH and C terminal domains<BR />
+
-
[[2wjy]] - hRENT1 helicase CH domains<BR />
+
-
[[2xzo]] – hRENT1 helicase domain + RNA<BR />
+
-
===ATP-dependent helicase Rho===
+
**[[3qln]] - hATRX ADD domain – human<BR />
 +
**[[2ld1]], [[2jm1]] - hATRX ADD domain - NMR<BR />
 +
**[[3ql9]] – hATRX ADD domain + histone H3 peptide <BR />
 +
**[[2lbm]] - hATRX ADD domain + histone H3 peptide – NMR<BR />
 +
**[[3qla]], [[3qlc]] - hATRX ADD domain (mutant) + histone H3 peptide<BR />
 +
**[[2xzp]] - hRENT1 helicase domain<BR />
 +
**[[2wjv]] - hRENT1 helicase CH and C terminal domains<BR />
 +
**[[2wjy]] - hRENT1 helicase CH domains<BR />
 +
**[[2xzo]] – hRENT1 helicase domain + RNA<BR />
-
[[3l0o]] – TmRho – ''Thermotoga maritima''<BR />
+
*ATP-dependent helicase Rho
-
[[3ice]] – EcRho + ADP + BeF3 + RNA<BR />
+
-
[[2ht1]] - EcRho + RNA<BR />
+
-
[[1a8v]] – EcRho RNA-binding domain<br />
+
-
[[2a8v]] – EcRho RNA-binding domain + RNA<br />
+
-
[[1pv4]] – EcRho + DNA<br />
+
-
[[1pvo]] – EcRho + ssRNA + ANPPNP<br />
+
-
[[1xpr]], [[1xpu]] - EcRho + ssRNA + antibiotic
+
-
===ATP-dependent helicase MFD===
+
**[[3l0o]] – TmRho – ''Thermotoga maritima''<BR />
 +
**[[3ice]] – EcRho + ADP + BeF3 + RNA<BR />
 +
**[[2ht1]] - EcRho + RNA<BR />
 +
**[[1a8v]] – EcRho RNA-binding domain<br />
 +
**[[2a8v]] – EcRho RNA-binding domain + RNA<br />
 +
**[[1pv4]] – EcRho + DNA<br />
 +
**[[1pvo]] – EcRho + ssRNA + ANPPNP<br />
 +
**[[1xpr]], [[1xpu]] - EcRho + ssRNA + antibiotic
-
[[3hjh]] – EcMFD motor domain
+
*ATP-dependent helicase MFD
-
===ATP-dependent helicase HEPA===
+
**[[3hjh]] – EcMFD motor domain
-
[[3dmq]] – EcHEPA
+
*ATP-dependent helicase HEPA
-
===ATP-dependent helicase E1===
+
**[[3dmq]] – EcHEPA
-
[[2v9p]] – PvE1 helicase domain – Bovine papillomavirus<br />
+
*ATP-dependent helicase E1
-
[[2gxa]] – PvE1 + DNA + Mg-ADP<br />
+
-
[[1tue]] – PvE1 + E2 – human papillomavirus
+
-
===ATP-dependent helicase CHD===
+
**[[2v9p]] – PvE1 helicase domain – Bovine papillomavirus<br />
 +
**[[2gxa]] – PvE1 + DNA + Mg-ADP<br />
 +
**[[1tue]] – PvE1 + E2 – human papillomavirus
-
[[2h1e]], [[2xb0]], [[3mwy]] – yCHD1 chromodomain<BR />
+
*ATP-dependent helicase CHD
-
[[2dy7]] - yCHD1 chromodomain 1 – NMR<BR />
+
-
[[2dy8]] - yCHD1 chromodomain 2 – NMR<BR />
+
-
[[3ted]] - yCHD1 chromodomain 1 + DNA<br />
+
-
[[2b2y]] – hCHD1 <br />
+
-
[[4b4c]] – hCHD1 DNA-binding domain<br />
+
-
[[2b2t]], [[2b2u]], [[2b2v]], [[2b2w]] – hCHD1 (mutant) + histone H3 tail<br />
+
-
[[4nw2]] – hCHD1 + NS1 peptide<br />
+
-
[[2ee1]] – hCHD4 chromodomain – NMR<br />
+
-
[[2l5u]] – hCHD4 PHD1 domain – NMR<br />
+
-
[[2l75]] – hCHD4 PHD2 domain + histone H3 peptide– NMR<br />
+
-
[[2epb]] – hCHD6 chromodomain – NMR<br />
+
-
[[2ckc]], [[2v0e]], [[2v0f]] – hCHD7 BRK domain - NMR <br />
+
-
[[2dl6]] – hCHD8 BRK domain - NMR <br />
+
-
[[2cka]] – hCHD8 <br />
+
-
===Dead box ATP-dependent RNA helicase===
+
**[[2h1e]], [[2xb0]], [[3mwy]] – yCHD1 chromodomain<BR />
 +
**[[2dy7]] - yCHD1 chromodomain 1 – NMR<BR />
 +
**[[2dy8]] - yCHD1 chromodomain 2 – NMR<BR />
 +
**[[3ted]] - yCHD1 chromodomain 1 + DNA<br />
 +
**[[2b2y]] – hCHD1 <br />
 +
**[[4b4c]] – hCHD1 DNA-binding domain<br />
 +
**[[2b2t]], [[2b2u]], [[2b2v]], [[2b2w]] – hCHD1 (mutant) + histone H3 tail<br />
 +
**[[4nw2]] – hCHD1 + NS1 peptide<br />
 +
**[[2ee1]] – hCHD4 chromodomain – NMR<br />
 +
**[[2l5u]] – hCHD4 PHD1 domain – NMR<br />
 +
**[[2l75]] – hCHD4 PHD2 domain + histone H3 peptide– NMR<br />
 +
**[[2epb]] – hCHD6 chromodomain – NMR<br />
 +
**[[2ckc]], [[2v0e]], [[2v0f]] – hCHD7 BRK domain - NMR <br />
 +
**[[2dl6]] – hCHD8 BRK domain - NMR <br />
 +
**[[2cka]] – hCHD8 <br />
-
[[3fho]] – DBP5 – fission yeast<BR />
+
*Dead box ATP-dependent RNA helicase
-
[[2kbe]] – yDBP5 N terminal – NMR<BR />
+
-
[[2kbf]] - yDBP5 C terminal – NMR<BR />
+
-
[[3gfp]] - yDBP5 C-terminal<BR />
+
-
[[2i4i]] – hDDX3X<BR />
+
-
[[2jgn]] – hDDX3X helicase domain<BR />
+
-
[[3ly5]] – hDDX18 dead domain<BR />
+
-
[[2rb4]] – hDDX25 helicase domain<BR />
+
-
[[2p6n]] – hDDX41 helicase domain (mutant) <BR />
+
-
[[2e29]], [[2m3d]] - hDDX50 GUCT domain - NMR<BR />
+
-
[[2rqa]] – hDHX58 C terminal – NMR<BR />
+
-
[[3eqt]] - hDHX58 C terminal + RNA<BR />
+
-
[[2eqs]] – hDHX8 S1 domain<BR />
+
-
[[3i4u]]– hDHX8 residues 950-1183<br />
+
-
[[1vec]] – hP54 N terminal<BR />
+
-
[[2hjv]] – BsDBPA domain 2 – ''Bacillus subtilis''<BR />
+
-
[[2g0c]] - BsDBPA RNA-binding domain<br />
+
-
[[3eaq]], [[3ear]], [[3eas]] – TtHera residues 215-426 - ''Thermus thermophiles''<br />
+
-
[[3i31]] - TtHera residues 431-517<br />
+
-
[[3i32]] - TtHera residues 218-517<br />
+
-
[[3nej]] - TtHera N terminal (mutant)
+
-
===Dead box ATP-dependent RNA helicase complexes===
+
**[[3fho]] – DBP5 – fission yeast<BR />
 +
**[[2kbe]] – yDBP5 N terminal – NMR<BR />
 +
**[[2kbf]] - yDBP5 C terminal – NMR<BR />
 +
**[[3gfp]] - yDBP5 C-terminal<BR />
 +
**[[2i4i]] – hDDX3X<BR />
 +
**[[2jgn]] – hDDX3X helicase domain<BR />
 +
**[[3ly5]] – hDDX18 dead domain<BR />
 +
**[[2rb4]] – hDDX25 helicase domain<BR />
 +
**[[2p6n]] – hDDX41 helicase domain (mutant) <BR />
 +
**[[2e29]], [[2m3d]] - hDDX50 GUCT domain - NMR<BR />
 +
**[[2rqa]] – hDHX58 C terminal – NMR<BR />
 +
**[[3eqt]] - hDHX58 C terminal + RNA<BR />
 +
**[[2eqs]] – hDHX8 S1 domain<BR />
 +
**[[3i4u]]– hDHX8 residues 950-1183<br />
 +
**[[1vec]] – hP54 N terminal<BR />
 +
**[[2hjv]] – BsDBPA domain 2 – ''Bacillus subtilis''<BR />
 +
**[[2g0c]] - BsDBPA RNA-binding domain<br />
 +
**[[3eaq]], [[3ear]], [[3eas]] – TtHera residues 215-426 - ''Thermus thermophilus''<br />
 +
**[[3i31]] - TtHera residues 431-517<br />
 +
**[[3i32]] - TtHera residues 218-517<br />
 +
**[[3nej]] - TtHera N terminal (mutant)
-
[[3rrm]] – yDBP5 residues 91-482 (mutant) + GLE1 + NUP159 + ADP + IP6 – yeast<BR />
+
*''Dead box ATP-dependent RNA helicase complexes''
-
[[3rrn]] - yDBP5 residues 91-482 (mutant) + GLE1 + IP6<BR />
+
-
[[3pew]], [[3pey]] - yDBP5 residues 91-482 (mutant) + ADP + BeF3 + RNA<BR />
+
-
[[3peu]], [[3pev]] - yDBP5 C-terminal (mutant) + GLE1 + IP6<BR />
+
-
[[3jrv]] – DDX3X + protein K7 – Vaccinia virus<BR />
+
-
[[3fmo]], [[3fhc]] – hDBP5 + Nup214<BR />
+
-
[[3fht]] – hDBP5 + AMPPNP + RNA<BR />
+
-
[[3fmp]] – hDDX19B + Nup214<br />
+
-
[[3g0h]] – hDDX19B residues 54-275 + ATP analog + RNA<BR />
+
-
[[3ews]] - hDDX19B residues 54-275 + ADP<BR />
+
-
[[3dkp]] – hDDX52 domain I + ADP<BR />
+
-
[[3tmi]] - hDHX58 residues 232-925 + RNA<br />
+
-
[[2wax]], [[2way]] – hDDX6 C terminal + EDC3-FDF peptide<BR />
+
-
[[2j0s]], [[2j0q]], [[2hyi]] – hDDX48 + protein mago nashi homolog + RNA-binding protein 8A + protein CASC3 + RNA<BR />
+
-
[[2j0u]] - hDDX48 + protein CASC3<BR />
+
-
[[2db3]] – VASA residues 200-623 + RNA – ''Drosophila melanogaster''<br />
+
-
[[3nbf]] - TtHera N terminal (mutant) + 8-oxo-ADP<br />
+
-
[[3moj]] - BsDBPA RNA-binding domain + RNA
+
-
===ATP-dependent RNA helicase===
+
**[[3rrm]] – yDBP5 residues 91-482 (mutant) + GLE1 + NUP159 + ADP + IP6 – yeast<BR />
 +
**[[3rrn]] - yDBP5 residues 91-482 (mutant) + GLE1 + IP6<BR />
 +
**[[3pew]], [[3pey]] - yDBP5 residues 91-482 (mutant) + ADP + BeF3 + RNA<BR />
 +
**[[3peu]], [[3pev]] - yDBP5 C-terminal (mutant) + GLE1 + IP6<BR />
 +
**[[3jrv]] – DDX3X + protein K7 – Vaccinia virus<BR />
 +
**[[3fmo]], [[3fhc]] – hDBP5 + Nup214<BR />
 +
**[[3fht]] – hDBP5 + AMPPNP + RNA<BR />
 +
**[[3fmp]] – hDDX19B + Nup214<br />
 +
**[[3g0h]] – hDDX19B residues 54-275 + ATP analog + RNA<BR />
 +
**[[3ews]] - hDDX19B residues 54-275 + ADP<BR />
 +
**[[3dkp]] – hDDX52 domain I + ADP<BR />
 +
**[[3tmi]] - hDHX58 residues 232-925 + RNA<br />
 +
**[[2wax]], [[2way]] – hDDX6 C terminal + EDC3-FDF peptide<BR />
 +
**[[2j0s]], [[2j0q]], [[2hyi]] – hDDX48 + protein mago nashi homolog + RNA-binding protein 8A + protein CASC3 + RNA<BR />
 +
**[[2j0u]] - hDDX48 + protein CASC3<BR />
 +
**[[2db3]] – VASA residues 200-623 + RNA – ''Drosophila melanogaster''<br />
 +
**[[3nbf]] - TtHera N terminal (mutant) + 8-oxo-ADP<br />
 +
**[[3moj]] - BsDBPA RNA-binding domain + RNA
-
[[2xzl]] – yNAM7 CH and helicase domains + RNA<BR />
+
*ATP-dependent RNA helicase
-
[[2xgj]] – yDOB1 residues 81-1073 + RNA<BR />
+
-
[[3l9o]] - yDOB1 residues 1-1073 + peptide<BR />
+
-
[[2xau]], [[3kx2]] – yPRP43 + ADP<BR />
+
-
[[3i5x]], [[3i5y]] – yMSS116 residues 37-597 + AMPPNP + RNA<BR />
+
-
[[3sqw]], [[3sqx]] - yMSS116 residues 88-664 + AMPPNP + RNA<br />
+
-
[[3i61]] - yMSS116 residues 37-597 + ADP + BeF3 + RNA<BR />
+
-
[[3i62]] - yMSS116 residues 37-597 + ADP + AlF4 + RNA<BR />
+
-
[[2vso]], [[2vsx]] – yEIF4A + initiation factor 4F middle domain<BR />
+
-
[[2g9n]] - hEIF4A dead domain
+
-
===Viral ATP-dependent RNA helicase NS3===
+
**[[2xzl]] – yNAM7 CH and helicase domains + RNA<BR />
 +
**[[2xgj]] – yDOB1 residues 81-1073 + RNA<BR />
 +
**[[3l9o]] - yDOB1 residues 1-1073 + peptide<BR />
 +
**[[2xau]], [[3kx2]] – yPRP43 + ADP<BR />
 +
**[[3i5x]], [[3i5y]] – yMSS116 residues 37-597 + AMPPNP + RNA<BR />
 +
**[[3sqw]], [[3sqx]] - yMSS116 residues 88-664 + AMPPNP + RNA<br />
 +
**[[3i61]] - yMSS116 residues 37-597 + ADP + BeF3 + RNA<BR />
 +
**[[3i62]] - yMSS116 residues 37-597 + ADP + AlF4 + RNA<BR />
 +
**[[2vso]], [[2vsx]] – yEIF4A + initiation factor 4F middle domain<BR />
 +
**[[2g9n]] - hEIF4A dead domain
-
[[3o8b]], [[3o8d]], [[1cu1]], [[8ohm]], [[1hei]], [[4a92]] – HvHel NS3 – Hepatitis C virus<BR />
+
*Viral ATP-dependent RNA helicase NS3
-
[[1onb]], [[1jr6]] - HvHel NS3 arginine-rich domain – NMR<BR />
+
-
[[2jlq]], [[2bhr]], [[2bmf]], [[2whx]], [[2wzq]] – DvHel NS3 residues 1646-2092 – Dengue virus<BR />
+
-
[[2z83]] – Hel NS3 residues 167-624 – Japanese encephalitis virus<BR />
+
-
[[2v8o]], [[2wv9]] - Hel NS3 helicase domain – Murray valley encephalitis virus<BR />
+
-
[[2qeq]] - Hel NS3 residues 1691-2124 – Kunjin virus<BR />
+
-
[[2v6i]] – KvHel helicase domain – Kokobera virus<BR />
+
-
[[2v6j]] - KvHel helicase domain (mutant)
+
-
===Viral ATP-dependent RNA helicase NS3 complexes===
+
**[[3o8b]], [[3o8d]], [[1cu1]], [[8ohm]], [[1hei]], [[4a92]] – HvHel NS3 – Hepatitis C virus<BR />
 +
**[[1onb]], [[1jr6]] - HvHel NS3 arginine-rich domain – NMR<BR />
 +
**[[2jlq]], [[2bhr]], [[2bmf]], [[2whx]], [[2wzq]] – DvHel NS3 residues 1646-2092 – Dengue virus<BR />
 +
**[[2z83]] – Hel NS3 residues 167-624 – Japanese encephalitis virus<BR />
 +
**[[2v8o]], [[2wv9]] - Hel NS3 helicase domain – Murray valley encephalitis virus<BR />
 +
**[[2qeq]] - Hel NS3 residues 1691-2124 – Kunjin virus<BR />
 +
**[[2v6i]] – KvHel helicase domain – Kokobera virus<BR />
 +
**[[2v6j]] - KvHel helicase domain (mutant)
-
[[3o8c]], [[3o8r]], [[3kqh]], [[3kqk]], [[3kql]], [[3kqn]], [[3kqu]], [[1a1v]] - HvHel NS3 + RNA<BR />
+
*''Viral ATP-dependent RNA helicase NS3 complexes''
-
[[2f9v]] - HvHel NS3 protease domain + polyprotein<BR />
+
-
[[2a4g]], [[1rtl]], [[1w3c]], [[1dxp]] - HvHel NS3 protease domain + NS4A peptide<BR />
+
-
[[2a4q]], [[2a4r]], [[2f9u]], [[2fm2]], [[1dy8]], [[1dy9]] - HvHel NS3 protease domain + NS4A peptide + inhibitor<BR />
+
-
[[2jlr]] - DvHel NS3 residues 1646-2092 + AMPPNP<BR />
+
-
[[2jls]] - DvHel NS3 residues 1646-2092 + ADP<BR />
+
-
[[2jlu]], [[2jlw]] - DvHel NS3 residues 1646-2092 + RNA<BR />
+
-
[[2jlv]] - DvHel NS3 residues 1646-2092 + AMPPNP + RNA<BR />
+
-
[[2jlx]], [[2jly]], [[2jlz]] - DvHel NS3 residues 1646-2092 + ADP + RNA<BR />
+
-
[[2vbc]] - DvHel NS3 residues 1475-2092 + NS2A peptide
+
-
===ATP-dependent RNA helicase SUV3===
+
**[[3o8c]], [[3o8r]], [[3kqh]], [[3kqk]], [[3kql]], [[3kqn]], [[3kqu]], [[1a1v]] - HvHel NS3 + RNA<BR />
 +
**[[2f9v]] - HvHel NS3 protease domain + polyprotein<BR />
 +
**[[2a4g]], [[1rtl]], [[1w3c]], [[1dxp]] - HvHel NS3 protease domain + NS4A peptide<BR />
 +
**[[2a4q]], [[2a4r]], [[2f9u]], [[2fm2]], [[1dy8]], [[1dy9]] - HvHel NS3 protease domain + NS4A peptide + inhibitor<BR />
 +
**[[2jlr]] - DvHel NS3 residues 1646-2092 + AMPPNP<BR />
 +
**[[2jls]] - DvHel NS3 residues 1646-2092 + ADP<BR />
 +
**[[2jlu]], [[2jlw]] - DvHel NS3 residues 1646-2092 + RNA<BR />
 +
**[[2jlv]] - DvHel NS3 residues 1646-2092 + AMPPNP + RNA<BR />
 +
**[[2jlx]], [[2jly]], [[2jlz]] - DvHel NS3 residues 1646-2092 + ADP + RNA<BR />
 +
**[[2vbc]] - DvHel NS3 residues 1475-2092 + NS2A peptide
-
[[3rc3]] – hSUV3 residues 47-722<BR />
+
*ATP-dependent RNA helicase SUV3
-
[[3og8]] – hDDX58 C terminal + RNA<BR />
+
-
[[3rc8]] - hSUV3 residues 47-722 + RNA<BR />
+
-
===ATP-dependent RNA helicase A===
+
**[[3rc3]] – hSUV3 residues 47-722<BR />
 +
**[[3og8]] – hDDX58 C terminal + RNA<BR />
 +
**[[3rc8]] - hSUV3 residues 47-722 + RNA<BR />
-
[[3llm]] – hHel A<BR />
+
*ATP-dependent RNA helicase A
-
[[3vyx]], [[3vyy]] - hHel A RNA-binding domain + RNA<br />
+
-
[[1whq]], [[2rs6]], [[2rs7]] – Hel A RNA-binding domain – mouse - NMR<BR />
+
-
===ATP-dependent RNA helicase Repa===
+
**[[3llm]] – hHel A<BR />
 +
**[[3vyx]], [[3vyy]] - hHel A RNA-binding domain + RNA<br />
 +
**[[1whq]], [[2rs6]], [[2rs7]] – Hel A RNA-binding domain – mouse - NMR<BR />
-
[[1uaa]] – EcRepa + DNA<br />
+
*ATP-dependent RNA helicase Repa
-
[[1nlf]] - EcRepa + sulfate<br />
+
-
[[1g8y]], [[1olo]] - EcRepa
+
-
===ATP-dependent RNA helicase HEF===
+
**[[1uaa]] – EcRepa + DNA<br />
 +
**[[1nlf]] - EcRepa + sulfate<br />
 +
**[[1g8y]], [[1olo]] - EcRepa
-
[[1x2i]] – HEF DNA-binding domain – ''Pyrococcus furiosus''
+
*ATP-dependent RNA helicase HEF
-
===Werner syndrome ATP-dependent DNA helicase===
+
**[[1x2i]] – HEF DNA-binding domain – ''Pyrococcus furiosus''
-
[[2e1e]], [[2e1f]], [[2dgz]] – hWRN HRDC domain<BR />
+
*Werner syndrome ATP-dependent DNA helicase
-
[[2fbt]] - hWRN exonuclease domain<BR />
+
-
[[2fbv]], [[2fbx]], [[2fby]], [[2fc0]] - hWRN exonuclease domain + metal ion
+
-
[[3aaf]] – hWRN C terminal + DNA<br />
+
-
[[2e6l]], [[2e6m]]- WRN exonuclease domain - mouse
+
-
===ATP-dependent DNA helicase Q===
+
**[[2e1e]], [[2e1f]], [[2dgz]] – hWRN HRDC domain<BR />
 +
**[[2fbt]] - hWRN exonuclease domain<BR />
 +
**[[2fbv]], [[2fbx]], [[2fby]], [[2fc0]] - hWRN exonuclease domain + metal ion
 +
**[[3aaf]] – hWRN C terminal + DNA<br />
 +
**[[2e6l]], [[2e6m]]- WRN exonuclease domain - mouse
-
[[2v1x]] - hQ1 residues 49-616<BR />
+
*ATP-dependent DNA helicase Q
-
[[2wwy]] – hQ1 residues 49-616 + DNA<br />
+
-
[[2kmu]] – hQ4 N terminal - NMR
+
-
===ATP-dependent DNA helicase RecG===
+
**[[2v1x]] - hQ1 residues 49-616<BR />
 +
**[[2wwy]] – hQ1 residues 49-616 + DNA<br />
 +
**[[2kmu]] – hQ4 N terminal - NMR
-
[[1gm5]] – TmRecG + DNA <BR />
+
*ATP-dependent DNA helicase RecG
-
===ATP-dependent DNA helicase RecQ===
+
**[[1gm5]] – TmRecG + DNA <BR />
-
[[3iuo]] – RecQ residues 604-725 – ''Porphyromonas gingivalis''<BR />
+
*ATP-dependent DNA helicase RecQ
-
[[2rhf]] – DrRecQ HRDC domain 3 – ''Deinococcus radiodurans''<BR />
+
-
[[2ma1]] - DrRecQ HRDC domain – NMR <br />
+
-
[[1wud]] - EcRecQ HRDC domain<BR />
+
-
[[1oyw]] - EcRecQ catalytic domain<BR />
+
-
[[1oyy]] - EcRecQ catalytic domain + ATP<BR />
+
-
[[1d8b]] - yRecQ HRDC domain - NMR<BR />
+
-
===ATP-dependent DNA helicase RuvA, RuvB===
+
**[[3iuo]] – RecQ residues 604-725 – ''Porphyromonas gingivalis''<BR />
 +
**[[2rhf]] – DrRecQ HRDC domain 3 – ''Deinococcus radiodurans''<BR />
 +
**[[2ma1]] - DrRecQ HRDC domain – NMR <br />
 +
**[[1wud]] - EcRecQ HRDC domain<BR />
 +
**[[1oyw]] - EcRecQ catalytic domain<BR />
 +
**[[1oyy]] - EcRecQ catalytic domain + ATP<BR />
 +
**[[1d8b]] - yRecQ HRDC domain - NMR<BR />
-
[[2ztc]], [[2ztd]], [[2zte]], [[2h5x]] – MtRuvA – ''Mycobacterium tuberculosis''<BR />
+
*ATP-dependent DNA helicase RuvA, RuvB
-
[[1bvs]] - RuvA – ''Mycobacterium leprae''<BR />
+
-
[[1cuk]], [[1hjp]] – EcRuvA<br />
+
-
[[1d8l]] – EcRuvA N terminal<BR />
+
-
[[1c7y]], [[1bdx]] – EcRuvA + DNA<BR />
+
-
[[1hqc]] – TtRuvB<br />
+
-
[[1ixr]], [[1ixs]] – TtRuvA + RuvB (mutant) <BR />
+
-
[[1in4]] – TmRuvB<BR />
+
-
[[1in5]], [[1in6]], [[1in7]], [[1in8]], [[1j7k]] – TmRuvB (mutant)<br />
+
-
[[3pfi]] – RuvB + ADP – ''Campylobacter jejuni''
+
-
===ATP-dependent DNA helicase UVSW===
+
**[[2ztc]], [[2ztd]], [[2zte]], [[2h5x]] – MtRuvA – ''Mycobacterium tuberculosis''<BR />
 +
**[[1bvs]] - RuvA – ''Mycobacterium leprae''<BR />
 +
**[[1cuk]], [[1hjp]] – EcRuvA<br />
 +
**[[1d8l]] – EcRuvA N terminal<BR />
 +
**[[1c7y]], [[1bdx]] – EcRuvA + DNA<BR />
 +
**[[1hqc]] – TtRuvB<br />
 +
**[[1ixr]], [[1ixs]] – TtRuvA + RuvB (mutant) <BR />
 +
**[[1in4]] – TmRuvB<BR />
 +
**[[1in5]], [[1in6]], [[1in7]], [[1in8]], [[1j7k]] – TmRuvB (mutant)<br />
 +
**[[3pfi]] – RuvB + ADP – ''Campylobacter jejuni''
-
[[2oca]], [[1rif]]- T4UVSW (mutant) – Enterobacteria phage T4<BR />
+
*ATP-dependent DNA helicase UVSW
-
[[2jpn]] - T4UVSW
+
-
===ATP-dependent DNA helicase UVRD===
+
**[[2oca]], [[1rif]]- T4UVSW (mutant) – Enterobacteria phage T4<BR />
 +
**[[2jpn]] - T4UVSW
-
[[2is1]] - EcUVRD + DNA
+
*ATP-dependent DNA helicase UVRD
-
===ATP-dependent DNA helicase PriA===
+
**[[2is1]] - EcUVRD + DNA
-
[[2d7e]] – EcPriA DNA-binding domain<BR />
+
*ATP-dependent DNA helicase PriA
-
[[2d7g]], [[2d7h]], [[2dwl]], [[2dwm]], [[2dwn]] – EcPriA N terminal + polynucleotide
+
-
===ATP-dependent DNA helicase PcrA===
+
**[[2d7e]] – EcPriA DNA-binding domain<BR />
 +
**[[2d7g]], [[2d7h]], [[2dwl]], [[2dwm]], [[2dwn]] – EcPriA N terminal + polynucleotide
-
[[1qhg]] – GsPcrA (mutant) + ADPNP – ''Geobacillus stearothermophilus''<BR />
+
*ATP-dependent DNA helicase PcrA
-
[[1qhh]] - GsPcrA + ADPNP<br />
+
-
[[2pjr]], [[3pjr]] - GsPcrA + DNA<br />
+
-
[[1pjr]] - GsPcrA
+
-
===DnaB helicase===
+
**[[1qhg]] – GsPcrA (mutant) + ADPNP – ''Geobacillus stearothermophilus''<BR />
 +
**[[1qhh]] - GsPcrA + ADPNP<br />
 +
**[[2pjr]], [[3pjr]] - GsPcrA + DNA<br />
 +
**[[1pjr]] - GsPcrA
-
[[3gxv]] – HpDnaB – ''Helicobacter pylori''<BR />
+
*DnaB helicase
-
[[4a1f]] – HpDnaB C terminal<br />
+
-
[[2r6d]] – BsDnaB – ''Bacillus stearothermophilus''<BR />
+
-
[[2r6e]], [[2r6d]] - GsDnaB <BR />
+
-
[[2r5u]] – MtDnaB N terminal<BR />
+
-
[[3bgw]] – BpDnaB-like – Bacillus phage SPP1<BR />
+
-
[[3bh0]] - BpDnaB-like G40P ATPase domain<BR />
+
-
[[2q6t]] – DnaB – ''Thermus aquaticus''<BR />
+
-
[[1mi8]] – DnaB – ''Synechocystis''<BR />
+
-
[[1b79]] - EcDnaB N terminal<BR />
+
-
[[1jwe]] - EcDnaB N terminal - NMR<BR />
+
-
[[2r6c]], [[2r6a]] – BsDnaB + DnaG helicase-binding domain
+
-
===DnaC helicase===
+
**[[3gxv]] – HpDnaB – ''Helicobacter pylori''<BR />
 +
**[[4a1f]] – HpDnaB C terminal<br />
 +
**[[2r6d]] – BsDnaB – ''Bacillus stearothermophilus''<BR />
 +
**[[2r6e]], [[2r6d]] - GsDnaB <BR />
 +
**[[2r5u]] – MtDnaB N terminal<BR />
 +
**[[3bgw]] – BpDnaB-like – Bacillus phage SPP1<BR />
 +
**[[3bh0]] - BpDnaB-like G40P ATPase domain<BR />
 +
**[[2q6t]] – DnaB – ''Thermus aquaticus''<BR />
 +
**[[1mi8]] – DnaB – ''Synechocystis''<BR />
 +
**[[1b79]] - EcDnaB N terminal<BR />
 +
**[[1jwe]] - EcDnaB N terminal - NMR<BR />
 +
**[[2r6c]], [[2r6a]] – BsDnaB + DnaG helicase-binding domain
-
[[2vyf]]– GkDnaC – ''Geobacillus kaustophilus''<br />
+
*DnaC helicase
-
[[2vye]] – GkDnaC + DNA <br />
+
-
[[3ec2]] – AaDnaC – ''Aquifex aeolicus''<br />
+
-
[[3ecc]] – AaDnaC + ADP<br />
+
-
===Helicase NSP2===
+
**[[2vyf]]– GkDnaC – ''Geobacillus kaustophilus''<br />
 +
**[[2vye]] – GkDnaC + DNA <br />
 +
**[[3ec2]] – AaDnaC – ''Aquifex aeolicus''<br />
 +
**[[3ecc]] – AaDnaC + ADP<br />
-
[[2hwk]] – NSP2 – Venzuelan equine encephalitis virus
+
*Helicase NSP2
-
===Helicase SNF2===
+
**[[2hwk]] – NSP2 – Venzuelan equine encephalitis virus
-
[[1z5z]] – SsSNF2 C terminal – ''Sulfolobus solfataricus''<br />
+
*Helicase SNF2
-
[[1z63]] - SsSNF2 ATPase core + DNA<br />
+
-
[[1z6a]] - SsSNF2 ATPase core
+
-
===Helicase SKI2===
+
**[[1z5z]] – SsSNF2 C terminal – ''Sulfolobus solfataricus''<br />
 +
**[[1z63]] - SsSNF2 ATPase core + DNA<br />
 +
**[[1z6a]] - SsSNF2 ATPase core
-
[[2va8]] – SsSKI2<br />
+
*Helicase SKI2
-
[[4a4k]] – ySKI2 insertion domain<br />
+
-
[[4a4z]] – ySKI2 + AMPPNP
+
-
===Helicase XPD===
+
**[[2va8]] – SsSKI2<br />
 +
**[[4a4k]] – ySKI2 insertion domain<br />
 +
**[[4a4z]] – ySKI2 + AMPPNP
-
[[3crv]], [[3crw]] – XPD – ''Sulfolobus acidocaldarius''<br />
+
*Helicase XPD
-
===Pre-mRNA-splicing Helicase (Brr2)===
+
**[[3crv]], [[3crw]] – XPD – ''Sulfolobus acidocaldarius''<br />
-
[[3hib]], [[3im1]], [[3im2]] – yBrr2 2nd SEC63 domain<br />
+
*Pre-mRNA-splicing Helicase (Brr2)
-
[[4bgd]] – yBrr2 + pre-mRNA-splicing factor 8<br />
+
 +
**[[3hib]], [[3im1]], [[3im2]] – yBrr2 2nd SEC63 domain<br />
 +
**[[4bgd]] – yBrr2 + pre-mRNA-splicing factor 8<br />
 +
}}
==References==
==References==
Crystal structure of a DExx box DNA helicase., Subramanya HS, Bird LE, Brannigan JA, Wigley DB, Nature. 1996 Nov 28;384(6607):379-83. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8934527 8934527]<br />
Crystal structure of a DExx box DNA helicase., Subramanya HS, Bird LE, Brannigan JA, Wigley DB, Nature. 1996 Nov 28;384(6607):379-83. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8934527 8934527]<br />

Revision as of 08:48, 27 November 2014

DNA-dependent helicase PcrA (PDB code 1pjr)

Drag the structure with the mouse to rotate

3D structures of helicase

Updated on 27-November-2014

References

Crystal structure of a DExx box DNA helicase., Subramanya HS, Bird LE, Brannigan JA, Wigley DB, Nature. 1996 Nov 28;384(6607):379-83. PMID:8934527
^ Johnson DS, Bai L, Smith BY, Patel SS, Wang MD (2007). "Single-molecule studies reveal dynamics of DNA unwinding by the ring-shaped t7 helicase". Cell 129 (7): 1299–309. doi:10.1016/j.cell.2007.04.038. PMID 17604719.
^ a b "Researchers solve mystery of how DNA strands separate" (2007-07-03). Retrieved on 2007-07-05.
^ Dumont S, Cheng W, Serebrov V, Beran RK, Tinoco Jr I, Pylr AM, Bustamante C, "RNA Translocation and Unwinding Mechanism of HCV NS3 Helicase and its Coordination by ATP", Nature. 2006 Jan 5; 439: 105-108. Anand SP, Zheng H, Bianco PR, Leuba SH, Khan SA. DNA helicase activity of PcrA is not required for displacement of RecA protein from DNA or inhibition of RecA-mediated DNA strand exchange. Journal of Bacteriology (2007) 189 (12):4502-4509.
Bird L, Subramanya HS, Wigley DB, "Helicases: a unifying structural theme?", Current Opinion in Structural Biology. 1998 Feb; 8 (1): 14-18.
Betterton MD, Julicher F, "Opening of nucleic-acid double strands by helicases: active versus passive opening.", Physical Review E. 2005 Jan; 71 (1): 011904.

  • Sengoku T, Nureki O, Nakamura A, Kobayashi S, Yokoyama S. Structural basis for RNA unwinding by the DEAD-box protein Drosophila Vasa. Cell. 2006 Apr 21;125(2):287-300. PMID:16630817 doi:10.1016/j.cell.2006.01.054
  • Sengoku T, Nureki O, Dohmae N, Nakamura A, Yokoyama S. Crystallization and preliminary X-ray analysis of the helicase domains of Vasa complexed with RNA and an ATP analogue. Acta Crystallogr D Biol Crystallogr. 2004 Feb;60(Pt 2):320-2. Epub 2004, Jan 23. PMID:14747711 doi:10.1107/S0907444903025897

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