Neuraminidase

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{{STRUCTURE_3nss| PDB=3nss | SIZE=400| SCENE= |right|CAPTION=Glycosylated Influenza virus neuraminidase complex with Ca+2 (green) and acetate, [[3nss]] }}
{{STRUCTURE_3nss| PDB=3nss | SIZE=400| SCENE= |right|CAPTION=Glycosylated Influenza virus neuraminidase complex with Ca+2 (green) and acetate, [[3nss]] }}
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[[4bbw]] – NAN – ''Bacterioides thetaiotaomicron''<br />
[[4bbw]] – NAN – ''Bacterioides thetaiotaomicron''<br />
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===Binary complexes of Neuraminidase===
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''Binary complexes of Neuraminidase''
[[3h72]] - SpNANA catalytic domain precursor + sialic derivative<br />
[[3h72]] - SpNANA catalytic domain precursor + sialic derivative<br />
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[[4b7m]] - IvNAN H1n1
[[4b7m]] - IvNAN H1n1
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===Binary complexes of Influenza virus neuraminidase===
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''Binary complexes of Influenza virus neuraminidase''
[[3o9j]], [[3o9k]], [[2c4a]], [[2c4l]], [[1w1x]], [[1w20]], [[1w21]], [[1nsb]], [[1nsc]], [[1nsd]] – IvNANA + sialic derivative<br />
[[3o9j]], [[3o9k]], [[2c4a]], [[2c4l]], [[1w1x]], [[1w20]], [[1w21]], [[1nsb]], [[1nsc]], [[1nsd]] – IvNANA + sialic derivative<br />

Revision as of 08:56, 19 August 2014

Template:STRUCTURE 3nss

Neuraminidase (NAN) cleaves the glycosidic bonds of neuraminic acid. The viral NAN is a drug target for prevention of influenza. See also

For other inhibitors see Neuraminidase Inhibitor Pharmacokinetics.

Contents

3D structures of Neuraminidase

Updated on 19-August-2014

Neuraminidase

2ya4, 2w20, 2vvz – SpNANA catalytic domain – Streptococcus pneumoniae
3h71 - SpNANA catalytic domain precursor
2vw0, 2vw1, 2vw2 - SpNANB
2xzi, 2xzj, 2xzk, 2xcy – NANA – Aspergillus fumigatus
2w68 – VcNANA sialic acid binding domain – Vibrio cholerae
1w0o, 1kit– VcNANA
1snt, 1so7 – hNeu2 - human
2f24, 2f26, 2f28 – hNeu2 (mutant)
1eur - MvNANA residues 43-407 – Micromonospora viridifaciens
1euu - MvNANA residues 47-647
1wcq, 1w8n, 1w8o, 2hu0, 2hu4 – MvNANA residues 47-647 (mutant)
3sil – StNANA (mutant) – Salmonella typhimurium
4bbw – NAN – Bacterioides thetaiotaomicron

Binary complexes of Neuraminidase

3h72 - SpNANA catalytic domain precursor + sialic derivative
3h73 - SpNANA catalytic domain precursor + sialic acid analog
2ya5 - SpNANA catalytic domain + sialic acid
2ya7, 2ya8 - SpNANA catalytic domain + inhibitor
2ya6 - SpNANA catalytic domain + sialic acid analog
2jkb - SpNANB residues 30-697 + sialic acid analog
4foq, 4fov, 4fow, 4foy, 4fp2, 4fp3, 4fpc, 4fpe, 4fpf, 4fpg, 4fph, 4fpj, 4fpk, 4fpl, 4fpo, 4fpy, 4fq4 – SpNANB + inhibitor
1w0p – VcNANA + sialic derivative
2f0z, 2f10, 2f11, 2f12, 2f13 – hNeu2 + inhibitor
2f25, 2f27, 2f29, 4nc5, 4ncs - hNeu2 (mutant) + sialic acid analog
1vcu - hNeu2 + sialic acid analog
1eus - MvNANA residues 43-407 + neuraminic acid derivative
2bzd - MvNANA residues 47-647 (mutant) + galactose
1eut - MvNANA residues 47-647 + galactose
2ber - MvNANA residues 47-647 (mutant) + sialic derivative
1dil, 1dim – StNANA + inhibitor
2sim, 2sil - StNANA + neuraminic acid derivative

Influenza virus neuraminidase

3nss, 3k36, 3beq, 3cye, 2cml, 2b8h, 2ht5, 1v0z, 1nn2, 4hzv – IvNANA residues 82-469 – Influenza virus
4fvk, 4gez - IvNANA residues 76-442
3k38, 4hzy – IvNANA (mutant)
4gzo, 4k1h, 4k1i, 4k1k - IvNAN N2 residues 77-469
4gzs, 4k1j - IvNAN N2 residues 77-469 (mutant)
2ht5 – IvNAN N8 residues 82-469
2htv - IvNAN N4 residues 82-469
3sal - IvNAN N5 residues 82-469
2hty - IvNAN N1 residues 82-469
3nn9, 4nn9, 5nn9, 6nn9, 4mwj, 4mwl - IvNAN N9 residues 82-469
7nn9 - IvNAN N9 Tern
2qwa - IvNAN N9 Tern (mutant)
4gdi, 4gdj - IvNAN N10
4b7m - IvNAN H1n1

Binary complexes of Influenza virus neuraminidase

3o9j, 3o9k, 2c4a, 2c4l, 1w1x, 1w20, 1w21, 1nsb, 1nsc, 1nsd – IvNANA + sialic derivative
3k37, 3b7e, 1vcj, 1l7f, 1f8c, 1f8d, 1f8e, 1a4g, 1a4q, 1b9t, 1b9v, 1b9s, 1inf, 1ing, 1inh, 1ivb, 1ivc, 1ivd, 1ive, 1ivf, 1ivg, 4d8s, 4ks1, 4ks2, 4ks3, 4ks4, 4ks5, 4m3m, 4mju, 4mjv – IvNANA + inhibitor
3ti3, 3ti4, 3ti5, 3ti6 – IvNAN H1n1 + inhibitor
4b7j, 4b7n, 4b7q, 4b7r - IvNAN H1n1 + drug
3tia, 3tib, 3tic – IvNAN H2n2 + inhibitor
1f8b, 1inv, 1inw, 1inx, 1iny, 4gb1 – IvNANA + sialic acid analog
2ht7, 2ht8, 2htq, 2htu – IvNAN N8 + inhibitor
2htr – IvNAN N8 + sialic acid analog
3san, 3ti8 - IvNAN N5 + flu drug
4hzw, 4hzx - IvNAN N3 + flu drug
4hzz, 4i00 - IvNAN N3 (mutant) + flu drug
2htw - IvNAN N4 + sialic acid analog
2bat, 4gzw, 4gzx, 4gzq – IvNAN N2 + sialic acid
4gzp, 4gzt - IvNAN N2 + drug
4h52, 4h53 – IvNAN N2 + inhibitor
1nna, 1nnb - IvNAN N9 + neuraminic acid derivative
4dgr - IvNAN N9 + benzoic acid derivative
1xoe, 1xog, 3w09 - IvNAN N9 Tern + inhibitor
4mwq, 4mwr, 4mwu, 4mwv, 4mww, 4mwx, 4mwy, 4mx0 - IvNAN N9 + flu drug
2qwb - IvNAN N9 Tern (mutant) + sialic derivative
2qwc, 2qwd, 2qwe - IvNAN N9 Tern (mutant) + sialic acid analog
1mwe - IvNAN N9 Tern + sialic acid
1bji, 1nnc - IvNAN N9 Tern + sialic acid analog
2qwf, 2qwg, 2qwh, 2qwi, 2qwj, 2qwk - IvNAN N9 Tern (mutant) + inhibitor
1nma, 1nmb, 1a14 1nca, 1ncb, 1ncc, 1ncd, 2aep, 2aeq, 1nmc - IvNAN N9 Tern + antibody – mouse
3k39, 3k3a, 3ckz, 3cl0, 3cl2, 1l7g, 1l7h - IvNANA (mutant) + inhibitor

Endo-neuraminidase

3gvf, 3gvk, 3gvj – ENANA (mutant) residues 246-910 – Enterobacteria phage K1F
3gvl, 3ju4 – ENANA residues 246-910
3gw6 – ENANA residues 790-1064

Pseudaminidase

2w38, 3h6j – PNANA – Pseudomonas aeruginosa

Trans-sialidase

2sli, 1sli, 3sli – lTS + inhibitor – leech

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman, Eran Hodis

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