Sulfotransferase

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{{#tree:id=OrganizedByTopic|openlevels=0|
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===Estrogen ST ===
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*Estrogen sulfotransferase
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[[1aqy]] – mST + PAP – mouse<BR />
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**[[1aqy]] – mST + PAP – mouse<BR />
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[[1aqu]] – mST + estradiol + PAP<BR />
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**[[1aqu]] – mST + estradiol + PAP<BR />
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[[1bo6]] - mST + VO4 + PAP<BR />
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**[[1bo6]] - mST + VO4 + PAP<BR />
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[[1hy3]] - hST (mutant) + PAP – human<BR />
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**[[1hy3]] - hST (mutant) + PAP – human<BR />
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[[4jvl]] - hST (mutant) + estradiol + PAP<br />
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**[[4jvl]] - hST (mutant) + estradiol + PAP<br />
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[[4jvm]], [[4jvn]] - hST (mutant) + flame retardant + PAP<br />
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**[[4jvm]], [[4jvn]] - hST (mutant) + flame retardant + PAP<br />
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[[1g3m]] - hST + tetrachloro-biphenyl-diol + PAP<BR />
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**[[1g3m]] - hST + tetrachloro-biphenyl-diol + PAP<BR />
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===Arylsulfate ST ===
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*Arylsulfate sulfotransferase
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[[3elq]] - EcST – ''Escherichia coli''<BR />
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**[[3elq]] - EcST – ''Escherichia coli''<BR />
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[[4p04]], [[4p07]] – EcST (mutant)<br />
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**[[4p04]], [[4p07]] – EcST (mutant)<br />
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[[3ets]] – EcST + methylumbelliferone<BR />
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**[[3ets]] – EcST + methylumbelliferone<BR />
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[[4p06]] - EcST (mutant) + methylumbelliferone<br />
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**[[4p06]] - EcST (mutant) + methylumbelliferone<br />
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[[3ett]] - EcST + p-nitrophenol + sulfate<br />
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**[[3ett]] - EcST + p-nitrophenol + sulfate<br />
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[[4p05]] – EcST (mutant) + nitrophenylsulfate <br />
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**[[4p05]] – EcST (mutant) + nitrophenylsulfate <br />
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===Hydroxysteroid ST ===
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*Hydroxysteroid sulfotransferase
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[[1efh]] - hST + PAP<BR />
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**[[1efh]] - hST + PAP<BR />
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===Alcohol ST===
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*Alcohol sulfotransferase
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[[1j99]] - hST + androsterone derivative<BR />
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**[[1j99]] - hST + androsterone derivative<BR />
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[[1ov4]] - hST (mutant) + androsterone derivative
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**[[1ov4]] - hST (mutant) + androsterone derivative
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===Pregnenolone ST===
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*Pregnenolone sulfotransferase
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[[1q1q]] - hST + PAP<BR />
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**[[1q1q]] - hST + PAP<BR />
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===Cholesterol ST===
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*Cholesterol sulfotransferase
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[[1q1z]] - hST + PAP<BR />
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**[[1q1z]] - hST + PAP<BR />
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[[1q20]], [[1q22]] - hST + cholesterol derivative + PAP<BR />
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**[[1q20]], [[1q22]] - hST + cholesterol derivative + PAP<BR />
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===Heparan sulfate ST ===
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*Heparan sulfate sulfotransferase
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[[1vkj]] - mST (mutant) + PAP<BR />
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**[[1vkj]] - mST (mutant) + PAP<BR />
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[[1t8t]] - hST catalytic domain + PAP<BR />
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**[[1t8t]] - hST catalytic domain + PAP<BR />
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[[3f5f]] – ST/MBP + PAP - chicken
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**[[3f5f]] – ST/MBP + PAP - chicken
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===Heparan sulfate glucosamine 3-o-ST===
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*Heparan sulfate glucosamine 3-o-sulfotransferase
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[[1zrh]] - hST + PAP<BR />
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**[[1zrh]] - hST + PAP<BR />
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[[3bd9]] - hST (mutant) + PAP<BR />
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**[[3bd9]] - hST (mutant) + PAP<BR />
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[[1t8u]] - hST catalytic domain + tetrasaccharide + PAP<BR />
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**[[1t8u]] - hST catalytic domain + tetrasaccharide + PAP<BR />
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[[3uan]] - mST + pentasaccharide + PAP<BR />
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**[[3uan]] - mST + pentasaccharide + PAP<BR />
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===Tyrosine-ester ST===
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*Tyrosine-ester sulfotransferase
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[[2zpt]], [[2zyt]] - mST + PAP<BR />
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**[[2zpt]], [[2zyt]] - mST + PAP<BR />
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[[2zvp]], [[2zyv]], [[2zyw]] - mST + p-nitrophenol + PAP<BR />
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**[[2zvp]], [[2zyv]], [[2zyw]] - mST + p-nitrophenol + PAP<BR />
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[[2zyu]] - mST + p-nitrophenyl sulfate + PAP<BR />
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**[[2zyu]] - mST + p-nitrophenyl sulfate + PAP<BR />
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[[2zvq]] - mST + α-naphthol + PAP<BR />
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**[[2zvq]] - mST + α-naphthol + PAP<BR />
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===Tyrosylprotein ST ===
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*Tyrosylprotein sulfotransferase
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[[3ap1]], [[3ap2]] - hST + peptide + PAP<BR />
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**[[3ap1]], [[3ap2]] - hST + peptide + PAP<BR />
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[[3ap3]] - hST + PAP<BR />
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**[[3ap3]] - hST + PAP<BR />
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===SULT1C2===
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*Sulfotransferase 1C2
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[[2ad1]] – hST<br />
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**[[2ad1]] – hST<br />
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[[3bfx]] - hST (mutant) + PAP<BR />
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**[[3bfx]] - hST (mutant) + PAP<BR />
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[[2gwh]] - hST + pentachlorophenol + PAP<BR />
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**[[2gwh]] - hST + pentachlorophenol + PAP<BR />
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===SULT1C3===
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*Sulfotransferase 1C3
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[[2h8k]] - hST + PAP<br />
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**[[2h8k]] - hST + PAP<br />
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===SULT4A1===
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*Sulfotransferase 1A4
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[[1zd1]] – hST
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**[[1zd1]] – hST
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===SULT1A3===
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*Sulfotransferase 1A3
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[[2a3r]] – hST + dopamine + PAP<BR />
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**[[2a3r]] – hST + dopamine + PAP<BR />
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[[1cjm]] - hST + sulfate
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**[[1cjm]] - hST + sulfate
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===SULT1A1===
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*Sulfotransferase 1A1
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[[3u3j]], [[4gra]] - hST + PAP<BR />
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**[[3u3j]], [[4gra]] - hST + PAP<BR />
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[[2d06]] – hST + estradiol + PAP<BR />
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**[[2d06]] – hST + estradiol + PAP<BR />
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[[3qvu]], [[3u3r]] – hST (mutant) + p-nitrophenol + PAP<BR />
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**[[3qvu]], [[3u3r]] – hST (mutant) + p-nitrophenol + PAP<BR />
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[[3qvv]] - hST (mutant) + hydroxyl-chromene-carbonitrile + PAP<BR />
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**[[3qvv]] - hST (mutant) + hydroxyl-chromene-carbonitrile + PAP<BR />
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[[1ls6]] - hST + p-nitrophenol + PAP<BR />
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**[[1ls6]] - hST + p-nitrophenol + PAP<BR />
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[[3u3k]] - hST + 3-naphthol + PAP<BR />
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**[[3u3k]] - hST + 3-naphthol + PAP<BR />
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[[3u3m]], [[3u3o]] - hST + 3-cyano-7-hydroxycoumarin + PAP<BR />
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**[[3u3m]], [[3u3o]] - hST + 3-cyano-7-hydroxycoumarin + PAP<BR />
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===SULT1A2===
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*Sulfotransferase 1A2
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[[1z28]], [[1z29]] - hST + hydroxyl-acetylamino fluorine
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**[[1z28]], [[1z29]] - hST + hydroxyl-acetylamino fluorine
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===SULT1B1===
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*Sulfotransferase 1B1
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[[2z5f]] - hST + PAP<BR />
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**[[2z5f]] - hST + PAP<BR />
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[[3ckl]] - hST + resveratrol + PAP<BR />
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**[[3ckl]] - hST + resveratrol + PAP<BR />
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===SULT2A1===
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*Sulfotransferase 2A1
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[[2qp3]], [[2qp4]] - hST (mutant) + aetiocholanolone<BR />
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**[[2qp3]], [[2qp4]] - hST (mutant) + aetiocholanolone<BR />
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[[3f3y]] - hST + lithocholic acid + PAP<BR />
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**[[3f3y]] - hST + lithocholic acid + PAP<BR />
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[[4ifb]] - hST (mutant) + PAP<br />
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**[[4ifb]] - hST (mutant) + PAP<br />
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===STF0 ST===
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*STF0 sulfotransferase
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[[1tex]], [[2zq5]] - ST – ''Mycobacterium smegmatis''
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**[[1tex]], [[2zq5]] - ST – ''Mycobacterium smegmatis''
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[[3rnl]] - ST – ''Alicyclobacillus acidocaldarius''<br />
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*Sulfotransferase
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[[4mua]] – SmST – ''Schistosoma mansoni''<br />
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[[4mub]] – SmST + oxamniquine<br />
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**[[3rnl]] - ST – ''Alicyclobacillus acidocaldarius''<br />
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**[[4mua]] – SmST – ''Schistosoma mansoni''<br />
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**[[4mub]] – SmST + oxamniquine<br />
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}}
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 12:00, 10 December 2014

Template:STRUCTURE 1hy3

Sulfotransferase (ST) are enzymes which catalyze the transfer of a sulfate group from a donor molecule to an acceptor alcohol or amine. The acceptors are hormones, neurotransmitters, drugs and xenobiotic compounds. The addition of a charged chemical moiety to the above carbon-rich water-insoluble molecules, make them more soluble and thus transportable in the circulatory system. The various human STs are named SULT### and differ in their tissue distribution and substrate specificities. The most common donor molecule is 3’-phosphoadenosine-5’-phosphosulfate (PAP).

3D structures of sulfotransferase

Updated on 10-December-2014

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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