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Acyl carrier protein synthase

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{{#tree:id=OrganizedByTopic|openlevels=0|
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===ACPS===
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*ACPS
-
[[1af8]], [[2af8]], [[2kg8]], [[2kg9]], [[2kga]], [[2kgc]], [[2kgd]], [[2kge]] – ScACPS – ''Streptomyces coelicolor'' – NMR<br />
+
**[[1af8]], [[2af8]], [[2kg8]], [[2kg9]], [[2kga]], [[2kgc]], [[2kgd]], [[2kge]] – ScACPS – ''Streptomyces coelicolor'' – NMR<br />
-
[[2jca]] - ScACPS <br />
+
**[[2jca]] - ScACPS <br />
-
[[1fte]], [[1ftf]] - SpACPS – ''Streptococcus pneumoniae''<br />
+
**[[1fte]], [[1ftf]] - SpACPS – ''Streptococcus pneumoniae''<br />
-
[[1f7l]], [[1f7t]] - BsACPS (mutant) – ''Bacillus subtilis''<br />
+
**[[1f7l]], [[1f7t]] - BsACPS (mutant) – ''Bacillus subtilis''<br />
-
[[3f09]], [[4jm7]] - SaACPS – ''Staphylococcus aureus''<br />
+
**[[3f09]], [[4jm7]] - SaACPS – ''Staphylococcus aureus''<br />
-
[[3hqj]], [[3h7q]], [[3ne1]], [[3ne3]], [[3ne9]], [[3nfd]] - MtACPS – ''Mycobacterium tuberculosis''<br />
+
**[[3hqj]], [[3h7q]], [[3ne1]], [[3ne3]], [[3ne9]], [[3nfd]] - MtACPS – ''Mycobacterium tuberculosis''<br />
-
[[4hc6]] – MtACPS<br />
+
**[[4hc6]] – MtACPS<br />
-
[[3gwm]] - ACPS – ''Mycobacterium smegmatis''<br />
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**[[3gwm]] - ACPS – ''Mycobacterium smegmatis''<br />
-
[[3qmn]] - ACPS – ''Vibrio cholera''
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**[[3qmn]] - ACPS – ''Vibrio cholera''
-
''ACPS complex''
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*ACPS complex
-
[[2jbz]] - ScACPS + CoA<br />
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**[[2jbz]] - ScACPS + CoA<br />
-
[[2wds]], [[2wdy]] - ScACPS (mutant) + CoA<br />
+
**[[2wds]], [[2wdy]] - ScACPS (mutant) + CoA<br />
-
[[2wdo]] - ScACPS + acetyl-CoA<br />
+
**[[2wdo]] - ScACPS + acetyl-CoA<br />
-
[[1fth]] – SpACPS + ADP<br />
+
**[[1fth]] – SpACPS + ADP<br />
-
[[1f80]] - BsACPS (mutant) + ACP<br />
+
**[[1f80]] - BsACPS (mutant) + ACP<br />
-
[[2qg8]] - ACPS + ADP – ''Plasmodium yoelii''<br />
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**[[2qg8]] - ACPS + ADP – ''Plasmodium yoelii''<br />
-
[[4dxe]] - SaACPS + ACP<br />
+
**[[4dxe]] - SaACPS + ACP<br />
-
[[3hyk]] - ACPS + ADP – ''Bacillus anthracis''
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**[[3hyk]] - ACPS + ADP – ''Bacillus anthracis''
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===β-ketoacyl-ACPS===
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*β-ketoacyl-ACPS
-
[[1w0i]] - AtACPS – ''Arabidopsis thaliana''<br />
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**[[1w0i]] - AtACPS – ''Arabidopsis thaliana''<br />
-
[[2ix4]] - AtACPS + hexanoic acid<br />
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**[[2ix4]] - AtACPS + hexanoic acid<br />
-
[[2c9h]], [[2iwy]], [[3hhd]] – hACPS – human<br />
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**[[2c9h]], [[2iwy]], [[3hhd]] – hACPS – human<br />
-
[[2iwz]] - hACPS + hexanoic acid<br />
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**[[2iwz]] - hACPS + hexanoic acid<br />
-
===β-ketoacyl-ACPS I===
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*β-ketoacyl-ACPS I
-
[[1dd8]], [[1g5x]], [[2buh]], [[2aq7]], [[2vb7]], [[2vb9]] - EcACPS I - ''Escherichia coli''<br />
+
**[[1dd8]], [[1g5x]], [[2buh]], [[2aq7]], [[2vb7]], [[2vb9]] - EcACPS I - ''Escherichia coli''<br />
-
[[1h4f]], [[2byw]], [[2byy]], [[2bz4]] - EcACPS I (mutant)<br />
+
**[[1h4f]], [[2byw]], [[2byy]], [[2bz4]] - EcACPS I (mutant)<br />
-
[[2wgd]] - MtACPS I <br />
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**[[2wgd]] - MtACPS I <br />
-
[[2wgf]] - MtACPS I (mutant)<br />
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**[[2wgf]] - MtACPS I (mutant)<br />
-
[[2was]] - yACPS I PPT domain – yeast<br />
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**[[2was]] - yACPS I PPT domain – yeast<br />
-
[[3oyt]] - ACPS I – ''Yersinia psetis''<br />
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**[[3oyt]] - ACPS I – ''Yersinia psetis''<br />
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''ACPS I complex''
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*ACPS I complex
-
[[1fj4]], [[1fj8]], [[2aqb]], [[2vb8]] - EcACPS I + antibiotic<br />
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**[[1fj4]], [[1fj8]], [[2aqb]], [[2vb8]] - EcACPS I + antibiotic<br />
-
[[2vba]] - EcACPS I + inhibitor<br />
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**[[2vba]] - EcACPS I + inhibitor<br />
-
[[1ek4]] - EcACPS I (mutant) + dodecanoic acid<br />
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**[[1ek4]] - EcACPS I (mutant) + dodecanoic acid<br />
-
[[2bui]] - EcACPS I + octanoic acid<br />
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**[[2bui]] - EcACPS I + octanoic acid<br />
-
[[1f91]], [[2byx]], [[2byz]], [[2bz3]] - EcACPS I (mutant) + fatty acid substrate<br />
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**[[2wge]] - MtACPS I + antibiotic<br />
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[[2wge]] - MtACPS I + antibiotic<br />
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**[[2wgg]] - MtACPS I (mutant) + antibiotic<br />
-
[[2wgg]] - MtACPS I (mutant) + antibiotic<br />
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**[[4c6u]], [[4c6v]], [[4c6w]] - MtACPS I + inhibitor<br />
-
[[4c6u]], [[4c6v]], [[4c6w]] - MtACPS I + inhibitor<br />
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**[[2wat]] - yACPS I PPT domain + CoA<br />
-
[[2wat]] - yACPS I PPT domain + CoA<br />
+
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===β-ketoacyl-ACPS II===
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*β-ketoacyl-ACPS II
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[[1e5m]] - ACPS II – ''Synechocytosis''<br />
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**[[1e5m]] - ACPS II – ''Synechocytosis''<br />
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[[1j3n]] - TtACPS II – ''Thermus thermophilus''<br />
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**[[1j3n]] - TtACPS II – ''Thermus thermophilus''<br />
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[[1ox0]], [[1oxh]] - SpACPS II<br />
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**[[1ox0]], [[1oxh]] - SpACPS II<br />
-
[[2alm]], [[2rjt]] - MtACPS II (mutant)<br />
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**[[2alm]], [[2rjt]] - MtACPS II (mutant)<br />
-
[[2gqd ]] - SaACPS II <br />
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**[[2gqd]] - SaACPS II <br />
-
[[2gp6]] - MtACPS II <br />
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**[[2gp6]] - MtACPS II <br />
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[[3e60]] – ACPS II – ''Bartonella henselae''<br />
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**[[3e60]] – ACPS II – ''Bartonella henselae''<br />
-
[[3kzu]] - ACPS II – ''Brucella melitensis''<br />
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**[[3kzu]] - ACPS II – ''Brucella melitensis''<br />
-
[[3o04]] - ACPS II – ''Listeria monocytogenes''<br />
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**[[3o04]] - ACPS II – ''Listeria monocytogenes''<br />
-
[[4ddo]] - BvACPS II – ''Burkholderia vietnamiensis''<br />
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**[[4ddo]] - BvACPS II – ''Burkholderia vietnamiensis''<br />
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[[1kas]], [[2gfw]] – EcACPS II<br />
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**[[1kas]], [[2gfw]] – EcACPS II<br />
-
[[2gfv]] - EcACPS II (mutant)<br />
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**[[2gfv]] - EcACPS II (mutant)<br />
-
[[4b7v]] - PaACPS II – ''Pseudonomas aeruginosa''<br />
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**[[4b7v]] - PaACPS II – ''Pseudonomas aeruginosa''<br />
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''ACPS II complex''
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*ACPS II complex
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[[1b3n]] - EcACPS II + antibiotic<br />
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**[[1b3n]] - EcACPS II + antibiotic<br />
-
[[2gfx]], [[3g0y]], [[3g11]], [[3hnz]], [[3ho2]], [[3ho9]], [[3i8p]] - EcACPS II (mutant) + antibiotic<br />
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**[[2gfx]], [[3g0y]], [[3g11]], [[3hnz]], [[3ho2]], [[3ho9]], [[3i8p]] - EcACPS II (mutant) + antibiotic<br />
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[[2gfy]] - EcACPS II (mutant) + dodecanoic acid<br />
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**[[2gfy]] - EcACPS II (mutant) + dodecanoic acid<br />
-
[[4f32]] - BvACPS II + antibiotic<br />
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**[[4f32]] - BvACPS II + antibiotic<br />
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===β-ketoacyl-ACPS III===
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*β-ketoacyl-ACPS III
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[[1hzp]], [[1m1m]] - MtACPS III <br />
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**[[1hzp]], [[1m1m]] - MtACPS III <br />
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[[1u6e]], [[2ahb]], [[2aj9]] - MtACPS III (mutant)<br />
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**[[1u6e]], [[2ahb]], [[2aj9]] - MtACPS III (mutant)<br />
-
[[1mzj]] - ACPS III – ''Streptomyces''<br />
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**[[1mzj]] - ACPS III – ''Streptomyces''<br />
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[[1zow]], [[3il7]] - SaACPS III <br />
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**[[1zow]], [[3il7]] - SaACPS III <br />
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[[2ebd]] - ACPS III – ''Aquifex aeolicus''<br />
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**[[2ebd]] - ACPS III – ''Aquifex aeolicus''<br />
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[[3gwa]], [[3gwe]] - ACPS III – ''Burkholderia pseudomallei''<br />
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**[[3gwa]], [[3gwe]] - ACPS III – ''Burkholderia pseudomallei''<br />
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[[4dfe]], [[4efi]] - ACPS III – ''Burkholderia xenovorans''<br />
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**[[4dfe]], [[4efi]] - ACPS III – ''Burkholderia xenovorans''<br />
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[[3il3]] - ACPS III – ''Haemophilus influenza''<br />
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**[[3il3]] - ACPS III – ''Haemophilus influenza''<br />
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[[3fk5]] - ACPS III – ''Xanthomonas oryzae''<br />
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**[[3fk5]] - ACPS III – ''Xanthomonas oryzae''<br />
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[[3led]] - ACPS III – ''Pseudonomas palustris''<br />
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**[[3led]] - ACPS III – ''Pseudonomas palustris''<br />
-
[[2x3e]] - ACPS III <br />
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**[[2x3e]] - ACPS III <br />
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[[1ebl]], [[1hn9]], [[1hnk]], [[3il9]] - EcACPS III
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**[[1ebl]], [[1hn9]], [[1hnk]], [[3il9]] - EcACPS III
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''ACPS III complex''
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*ACPS III complex
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+
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[[1hnd]], [[1hnh]], [[2gyo]], [[2eft]] - EcACPS III + CoA<br />
+
-
[[1hnj]] - EcACPS III + malonyl-CoA<br />
+
-
[[2qx1]] - EcACPS III + decyl-CoA<br />
+
-
[[1mzs]] - EcACPS III + inhibitor<br />
+
-
[[1u6s]] - MtACPS III (mutant) + lauroyl-CoA<br />
+
-
[[2qnx]], [[2qo1]] - MtACPS III + undecanoic acid<br />
+
-
[[2qo0]] - MtACPS III (mutant) + undecanoic acid<br />
+
-
[[2qnz]] - MtACPS III + decyl formate<br />
+
-
[[2qny]] - MtACPS III (mutant) + decyl formate<br />
+
-
[[1ub7]] - TtACPS III (mutant)<br />
+
-
[[3il4]] - EfACPS III + CoA – ''Enterococcus faecalis''<br />
+
-
[[3il5]] - EfACPS III + benzoic acid derivative<br />
+
-
[[3il6]] - EfACPS III (mutant) + benzoic acid derivative
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 +
**[[1hnd]], [[1hnh]], [[2gyo]], [[2eft]] - EcACPS III + CoA<br />
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**[[1hnj]] - EcACPS III + malonyl-CoA<br />
 +
**[[2qx1]] - EcACPS III + decyl-CoA<br />
 +
**[[1mzs]] - EcACPS III + inhibitor<br />
 +
**[[1u6s]] - MtACPS III (mutant) + lauroyl-CoA<br />
 +
**[[2qnx]], [[2qo1]] - MtACPS III + undecanoic acid<br />
 +
**[[2qo0]] - MtACPS III (mutant) + undecanoic acid<br />
 +
**[[2qnz]] - MtACPS III + decyl formate<br />
 +
**[[2qny]] - MtACPS III (mutant) + decyl formate<br />
 +
**[[1ub7]] - TtACPS III (mutant)<br />
 +
**[[3il4]] - EfACPS III + CoA – ''Enterococcus faecalis''<br />
 +
**[[3il5]] - EfACPS III + benzoic acid derivative<br />
 +
**[[3il6]] - EfACPS III (mutant) + benzoic acid derivative
 +
}}
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 10:54, 12 November 2014

Acyl carrier protein synthase complex with CoA and Mg+2 ion (cyan) 3hqj

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3D structures of acyl carrier protein synthase

Updated on 12-November-2014









References

  • Parris KD, Lin L, Tam A, Mathew R, Hixon J, Stahl M, Fritz CC, Seehra J, Somers WS. Crystal structures of substrate binding to Bacillus subtilis holo-(acyl carrier protein) synthase reveal a novel trimeric arrangement of molecules resulting in three active sites. Structure. 2000 Aug 15;8(8):883-95. PMID:10997907
  • Dym O, Albeck S, Peleg Y, Schwarz A, Shakked Z, Burstein Y, Zimhony O. Structure-function analysis of the acyl carrier protein synthase (AcpS) from Mycobacterium tuberculosis. J Mol Biol. 2009 Nov 6;393(4):937-50. Epub 2009 Sep 3. PMID:19733180 doi:10.1016/j.jmb.2009.08.065

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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