Dipeptidyl peptidase
From Proteopedia
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{{STRUCTURE_1jqp| PDB=1jqp | SIZE=400| SCENE=Dipeptidyl_peptidase/Cv/1 |right|CAPTION=Glycosylated dipeptidyl peptidase complex with sulfate and chloride ion (green) [[1jqp]]}} | {{STRUCTURE_1jqp| PDB=1jqp | SIZE=400| SCENE=Dipeptidyl_peptidase/Cv/1 |right|CAPTION=Glycosylated dipeptidyl peptidase complex with sulfate and chloride ion (green) [[1jqp]]}} | ||
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
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| - | + | *DPP-I | |
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| - | + | **[[1jqp]] – rDPP-I – rat<br /> | |
| + | **[[1k3b]], [[2djg]] - hDPP-I – human<br /> | ||
| + | **[[3pdf]], [[2djf]] – hDPP-I + inhibitor | ||
| - | + | *DPP-II | |
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| - | + | **[[3n0t]] – hDPP-II peptidase domain residues 28-492+inhibitor<br /> | |
| + | **[[3jyh]], [[4ebb]] – hDPP-II peptidase domain residues 28-492<br /> | ||
| - | + | *DPP-III | |
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| - | + | **[[3fvy]] – hDPP-III<br /> | |
| + | **[[3t6b]], [[3t6j]] - hDPP-III (mutant) + tynorphin<br /> | ||
| + | **[[3csk]] – DPP-III (mutant) – yeast<br /> | ||
| - | + | *DPP-IV (CD26) | |
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| - | + | **[[2onc]], [[1tk3]], [[1r9m]], [[1j2e]], [[1nu6]], [[1pfq]] – hDPP-IV extracellular domain<br /> | |
| + | **[[1u8e]] – hDPP-IV extracellular domain (mutant)<br /> | ||
| + | **[[3kwj]], [[3oc0]], [[3kwf]], [[3q8w]] – hDPP-IV extracellular domain +quinoline derivative<br /> | ||
| + | **[[3g0b]], [[3g0d]], [[3g0g]], [[3nox]], [[3hab]], [[3hac]], [[3f8s]], [[3h0c]], [[3ccb]], [[3ccc]], [[2qjr]], [[2qky]], [[3d4l]], [[2jid]], [[3bjm]], [[2rip]], [[2ole]], [[2rgu]], [[2i78]], [[2oag]], [[2oqv]], [[2oqi]], [[2ogz]], [[2i03]], [[2g5p]], [[2g5t]], [[2g63]], [[2bub]], [[2ajl]], [[1wcy]], [[1rwq]], [[1tkr]], [[1n1m]], [[3eio]], [[3g0c]], [[3opm]], [[3sww]], [[3sx4]], [[3q0t]], [[4a5s]], [[3vjk]], [[3vjl]], [[3vjm]], [[3w2t]], [[4dsa]], [[4dsz]], [[4dtc]], [[4g1f]],[[3o95]], [[3o9v]], [[4j3j]], [[4jh0]], [[4lko]], [[4n8d]], [[4n8e]] – hDPP-IV extracellular domain+inhibitor<br /> | ||
| + | **[[1r9n]], [[2bgr]], [[1nu8]] – hDPP-IV extracellular domain+polypeptide<br /> | ||
| + | **[[1w1i]] – hDPP-IV extracellular domain+adenosine deaminase<br /> | ||
| + | **[[2bgn]] – hDPP-IV extracellular domain+adenosine deaminase+polypeptide<br /> | ||
| + | **[[3c43]], [[3c45]], [[2qoe]], [[2qt9]], [[2qtb]], [[2p8s]], [[2oph]], [[2fjp]], [[1x70]], [[2iit]], [[2iiv]], [[3qbj]] – hDPP-IV extracellular domain (mutant) + inhibitor <br /> | ||
| + | **[[4kr0]] - hDPP-IV extracellular domain + S protein<br /> | ||
| + | **[[4l72]] – rDPP-IV + Mers-Cov Rbd<br /> | ||
| + | **[[2gbc]] – rDPP-IV extracellular domain<br /> | ||
| + | **[[2oae]], [[2i3z]], [[2gbf]], [[2gbg]], [[2gbi]] – rDPP-IV extracellular domain+inhibitor<br /> | ||
| + | **[[4ffv]], [[4ffw]] – rDPP-IV + antibody<br /> | ||
| + | **[[2aj8]], [[2ajb]], [[2ajc]], [[2ajd]], [[2bua]], [[2buc]], [[1orw]] – pDPP-IV extracellular domain+inhibitor - pig<br /> | ||
| + | **[[1orv]] - pDPP-IV extracellular domain<br /> | ||
| + | **[[2ecf]] - DPP-IV – ''Stenotrophomonas maltophilia'' | ||
| - | + | *DPP-VI | |
| + | **[[3pvq]] – DPP-VI – ''Bacterioides thetaiotamicron'' | ||
| + | }} | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 08:39, 24 November 2014
Dipeptidyl peptidase (DPP) is an enzyme which cleaves dipeptides from polypeptides.
- DPP-I is involved in inflammatory diseases.
- DPP-II is a serine protease.
- DPP-III acts similarly to DPP-IV.
- DPP-IV (or CD26) cleaves proline dipeptides from the N-termini and is associated with immune regulation.
The images at the left and at the right correspond to one representative DPP, i.e. the crystal structure of Dipeptidyl peptidase-I from rat (1jqp). See also Dipeptidyl Peptidase-4 Inhibitor Pharmacokinetics.
3D Structures of Dipeptidyl peptidase
Updated on 24-November-2014
