Resolvase

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{{#tree:id=OrganizedByTopic|openlevels=0|
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=== Holliday junction resolvase ===
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* Holliday junction resolvase
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[[2wiw]], [[2wiz]], [[2wj0]] – AfHJR+DNA – ''Archaeoglobus fulgidus''<br />
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**[[2wiw]], [[2wiz]], [[2wj0]] – AfHJR+DNA – ''Archaeoglobus fulgidus''<br />
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[[2wcw]], [[2wcz]] – AfHJR (mutant)<br />
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**[[2wcw]], [[2wcz]] – AfHJR (mutant)<br />
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[[2h8c]] – EcHJR RusA (mutant) + DNA – ''Escherichia coli''<br />
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**[[2h8c]] – EcHJR RusA (mutant) + DNA – ''Escherichia coli''<br />
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[[1gdt]] - EcHJR +DNA<br />
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**[[1gdt]] - EcHJR +DNA<br />
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[[2h8e]] - EcHJR RusA (mutant)<br />
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**[[2h8e]] - EcHJR RusA (mutant)<br />
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[[1q8r]] – EcHJR RusA<br />
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**[[1q8r]] – EcHJR RusA<br />
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[[1hjr]] – EcHJR RuvC<br />
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**[[1hjr]] – EcHJR RuvC<br />
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[[4ep4]] – TtHJR RuvC – ''Thermus thermophilus''<br />
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**[[4ep4]] – TtHJR RuvC – ''Thermus thermophilus''<br />
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[[4ep5]] – TtHJR RuvC (mutant)<br />
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**[[4ep5]] – TtHJR RuvC (mutant)<br />
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[[1zp7]] – HJR RecU – ''Bacillus subtilis''<br />
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**[[1zp7]] – HJR RecU – ''Bacillus subtilis''<br />
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[[1ob8]], [[1ob9]], [[1hh1]] – SsHJR – ''Sulfolobus solfataricus''<br />
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**[[1ob8]], [[1ob9]], [[1hh1]] – SsHJR – ''Sulfolobus solfataricus''<br />
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[[2fco]] – HJR – ''Geobacillus kaustophilus''<br />
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**[[2fco]] – HJR – ''Geobacillus kaustophilus''<br />
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[[1ipi]], [[1gef]] – HJR – ''Pyrococcus furiosus''<br />
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**[[1ipi]], [[1gef]] – HJR – ''Pyrococcus furiosus''<br />
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[[1kcf]] – HJR – fission yeast<br />
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**[[1kcf]] – HJR – fission yeast<br />
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=== Ser-recombinase ===
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* Ser-recombinase
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[[2rsl]] - EcGDR<br />
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**[[2rsl]] - EcGDR<br />
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[[1hx7]] – EcGDR N-terminal – NMR<br />
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**[[1hx7]] – EcGDR N-terminal – NMR<br />
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[[1ght]], [[1res]], [[1ret]], [[1ght]] – EcGDR catalytic domain – NMR<br />
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**[[1ght]], [[1res]], [[1ret]], [[1ght]] – EcGDR catalytic domain – NMR<br />
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[[1gdr]], [[1hx7]] - EcGDR catalytic domain<br />
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**[[1gdr]], [[1hx7]] - EcGDR catalytic domain<br />
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[[2gm4]], [[1zr2]], [[1zr4]], [[1gdt]] – EcGDR+DNA<br />
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**[[2gm4]], [[1zr2]], [[1zr4]], [[1gdt]] – EcGDR+DNA<br />
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[[2gm5]] – EcGDR (mutant)<br />
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**[[2gm5]] – EcGDR (mutant)<br />
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[[3guv]] – site-specific recombinase – ''Streptococcus pneumoniae''<br />
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**[[3guv]] – site-specific recombinase – ''Streptococcus pneumoniae''<br />
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[[2r0q]] – S-rec+DNA – ''Staphylococcus aureus''<br />
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**[[2r0q]] – S-rec+DNA – ''Staphylococcus aureus''<br />
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[[3lhf]] – SsS-rec<br />
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**[[3lhf]] – SsS-rec<br />
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=== Tyr-recombinase ===
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* Tyr-recombinase
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[[3etl]], [[3ew9]], [[3ewa]], [[2i1q]] – MmRadA Rec+AMPPNP+ion – ''Methanococcus maripaludis''<br />
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**[[3etl]], [[3ew9]], [[3ewa]], [[2i1q]] – MmRadA Rec+AMPPNP+ion – ''Methanococcus maripaludis''<br />
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[[2b21]] - MmRadA Rec+AMPPNP<br />
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**[[2b21]] - MmRadA Rec+AMPPNP<br />
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[[2zub]], [[2zuc]], [[2zud]], [[2dfl]] – SsRadA<br />
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**[[2zub]], [[2zuc]], [[2zud]], [[2dfl]] – SsRadA<br />
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[[2cvf]], [[2cvh]] – RadB Rec – ''Thermococcus kodakarensis''<br />
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**[[2cvf]], [[2cvh]] – RadB Rec – ''Thermococcus kodakarensis''<br />
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[[2f1h]], [[2fpl]], [[2fpm]] - MvRec+AMPPNP+K – ''Methanococcus voltae''<br />
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**[[2f1h]], [[2fpl]], [[2fpm]] - MvRec+AMPPNP+K – ''Methanococcus voltae''<br />
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[[2f1i]] – MvRec+AMPPNP<br />
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**[[2f1i]] – MvRec+AMPPNP<br />
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[[2f1j]], [[2fpk]] - MvRec+ADP<br />
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**[[2f1j]], [[2fpk]] - MvRec+ADP<br />
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[[1a0p]] – EcXerd Rec<br />
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**[[1a0p]] – EcXerd Rec<br />
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=== Cre recombinase ===
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* Cre recombinase
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[[3mgv]], [[3c28]], [[3c29]], [[2hof]], [[2hoi]], [[1xns]], [[1xo0]], [[1pvp]], [[1pvq]], [[1pvr]], [[1nzb]], [[1ouq]], [[1q3u]], [[1q3v]], [[1ma7]], [[1kbu]], [[1drg]], [[1f44]], [[2crx]], [[3crx]], [[4crx]], [[5crx]], [[1crx]] – EpCre+DNA – Enterobacteria phage PI<br />
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**[[3mgv]], [[3c28]], [[3c29]], [[2hof]], [[2hoi]], [[1xns]], [[1xo0]], [[1pvp]], [[1pvq]], [[1pvr]], [[1nzb]], [[1ouq]], [[1q3u]], [[1q3v]], [[1ma7]], [[1kbu]], [[1drg]], [[1f44]], [[2crx]], [[3crx]], [[4crx]], [[5crx]], [[1crx]] – EpCre+DNA – Enterobacteria phage PI<br />
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=== Integrase ===
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* Integrase
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[[2a3v]] – Rec INTI4+DNA – ''Vibrio cholerae''<br />
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**[[2a3v]] – Rec INTI4+DNA – ''Vibrio cholerae''<br />
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[[3bvp]] – Integrase N-terminal – Lactococcus phage<br />
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**[[3bvp]] – Integrase N-terminal – Lactococcus phage<br />
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[[2oxo]] – LamInt binding domain – phage<br />
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**[[2oxo]] – LamInt binding domain – phage<br />
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[[1z19]] – EpLamInt core binding +catalytic domain+DNA<br />
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**[[1z19]] – EpLamInt core binding +catalytic domain+DNA<br />
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[[1z1b]], [[1z1g]], [[1p7d]] – EpLamInt+DNA<br />
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**[[1z1b]], [[1z1g]], [[1p7d]] – EpLamInt+DNA<br />
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[[1kjk]] – EpLamInt N-terminal – NMR<br />
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**[[1kjk]] – EpLamInt N-terminal – NMR<br />
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[[1ae9]] – EpLamInt catalytic core<br />
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**[[1ae9]] – EpLamInt catalytic core<br />
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[[1p4e]], [[1m6x]] – yFLP (mutant)+DNA – yeast<br />
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**[[1p4e]], [[1m6x]] – yFLP (mutant)+DNA – yeast<br />
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[[1flo]] - yFLP +DNA<br />
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**[[1flo]] - yFLP +DNA<br />
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[[1aih]] – HP1 integrase catalytic domain - bacteriophage<br />
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**[[1aih]] – HP1 integrase catalytic domain - bacteriophage<br />
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[[3nrw]] – INT/site-specific recombinase N-terminal – ''Haloarcula marismortui''<br />
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**[[3nrw]] – INT/site-specific recombinase N-terminal – ''Haloarcula marismortui''<br />
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[[3jtz]] – INT arm-type binding domain – ''Yersinia pestis''<br />
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**[[3jtz]] – INT arm-type binding domain – ''Yersinia pestis''<br />
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[[3ju0]] – HPI INT arm-type binding domain – ''Pectobacterium atrosepticum''<br />
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**[[3ju0]] – HPI INT arm-type binding domain – ''Pectobacterium atrosepticum''<br />
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[[2kkp]] – INT SAM-like domain – ''Moorella thermoacetica'' – NMR<br />
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**[[2kkp]] – INT SAM-like domain – ''Moorella thermoacetica'' – NMR<br />
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[[2kkv]] – INT fragment – ''Salmonella enterica'' – NMR<br />
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**[[2kkv]] – INT fragment – ''Salmonella enterica'' – NMR<br />
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[[2khq]] - INT fragment – ''Staphylococcus saprophyticus'' – NMR<br />
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**[[2khq]] - INT fragment – ''Staphylococcus saprophyticus'' – NMR<br />
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[[2wcc]] – λINT DBD+ DNA – Enterobacteria phage λ - NMR<br />
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**[[2wcc]] – λINT DBD+ DNA – Enterobacteria phage λ - NMR<br />
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[[2khv]], [[2kj5]] – INT residues 102-199 – ''Nitrosospira multiformis'' – NMR<br />
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**[[2khv]], [[2kj5]] – INT residues 102-199 – ''Nitrosospira multiformis'' – NMR<br />
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===Recombinase A (RecA)===
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[[Recombinase A]]
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*Recombinase A (RecA) see [[Recombinase A]]
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}}
==References==
==References==
<references />
<references />
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 10:10, 7 December 2014

Template:STRUCTURE 1kcf Resolvase or recombinase (Rec) is a nuclease which is involved in DNA recombination. The Holliday junction resolvase (HJR) resolves 4-way DNA intermediates known as Holliday junctions. Recombination of 2 DNA sites occurs when recombinase binds to the 2 strands. According to the binding residue, the recombinases are grouped to Tyr- and Ser-recombinase. Tyr-recombinases include Cre which recombines loxP sites, FLP and lambda integrase (LamInt). Ser-recombinases (S-rec) include gamma-delta resolvase (GDR), Tn3 resolvase and phiC31 integrase. RadA recombinase promotes DNA recombination. Detailed analysis of its suggests mechanisms for junction isomerization and communication between the two active sites [1].

3D structures of resolvase

Updated on 07-December-2014

References

  1. ↑ Ceschini S, Keeley A, McAlister MS, Oram M, Phelan J, Pearl LH, Tsaneva IR, Barrett TE. Crystal structure of the fission yeast mitochondrial Holliday junction resolvase Ydc2. EMBO J. 2001 Dec 3;20(23):6601-11. PMID:11726496 doi:10.1093/emboj/20.23.6601

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman, Jaime Prilusky

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