1w21

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== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1w21]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Influenza_a_virus Influenza a virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W21 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1W21 FirstGlance]. <br>
<table><tr><td colspan='2'>[[1w21]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Influenza_a_virus Influenza a virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W21 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1W21 FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene><br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>
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<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1a14|1a14]], [[1a4g|1a4g]], [[1a4q|1a4q]], [[1b9s|1b9s]], [[1b9t|1b9t]], [[1b9v|1b9v]], [[1bji|1bji]], [[1e8t|1e8t]], [[1e8u|1e8u]], [[1e8v|1e8v]], [[1euu|1euu]], [[1f8b|1f8b]], [[1f8c|1f8c]], [[1f8d|1f8d]], [[1f8e|1f8e]], [[1inf|1inf]], [[1ing|1ing]], [[1inh|1inh]], [[1inv|1inv]], [[1inw|1inw]], [[1inx|1inx]], [[1iny|1iny]], [[1ivb|1ivb]], [[1ivc|1ivc]], [[1ivd|1ivd]], [[1ive|1ive]], [[1ivf|1ivf]], [[1ivg|1ivg]], [[1kit|1kit]], [[1l7f|1l7f]], [[1l7g|1l7g]], [[1l7h|1l7h]], [[1mwe|1mwe]], [[1nca|1nca]], [[1ncb|1ncb]], [[1ncc|1ncc]], [[1ncd|1ncd]], [[1nma|1nma]], [[1nmb|1nmb]], [[1nmc|1nmc]], [[1nn2|1nn2]], [[1nna|1nna]], [[1nnb|1nnb]], [[1nnc|1nnc]], [[1nsb|1nsb]], [[1nsc|1nsc]], [[1nsd|1nsd]], [[1usr|1usr]], [[1usx|1usx]], [[1v2i|1v2i]], [[1v3b|1v3b]], [[1v3c|1v3c]], [[1v3d|1v3d]], [[1v3e|1v3e]], [[1vcj|1vcj]], [[1w1x|1w1x]], [[1w20|1w20]], [[1v0z|1v0z]], [[1w8n|1w8n]], [[1w8o|1w8o]], [[1xoe|1xoe]], [[1xog|1xog]], [[1z4v|1z4v]], [[1z4w|1z4w]], [[1z4x|1z4x]], [[1z4y|1z4y]], [[1z4z|1z4z]], [[1z50|1z50]], [[2bat|2bat]], [[2qwa|2qwa]], [[2qwb|2qwb]], [[2qwc|2qwc]], [[2qwd|2qwd]], [[2qwe|2qwe]], [[2qwf|2qwf]], [[2qwg|2qwg]], [[2qwh|2qwh]], [[2qwi|2qwi]], [[2qwj|2qwj]], [[2qwk|2qwk]], [[2sil|2sil]], [[2sim|2sim]], [[3nn9|3nn9]], [[4nn9|4nn9]], [[5nn9|5nn9]], [[6nn9|6nn9]], [[7nn9|7nn9]]</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1a14|1a14]], [[1a4g|1a4g]], [[1a4q|1a4q]], [[1b9s|1b9s]], [[1b9t|1b9t]], [[1b9v|1b9v]], [[1bji|1bji]], [[1e8t|1e8t]], [[1e8u|1e8u]], [[1e8v|1e8v]], [[1euu|1euu]], [[1f8b|1f8b]], [[1f8c|1f8c]], [[1f8d|1f8d]], [[1f8e|1f8e]], [[1inf|1inf]], [[1ing|1ing]], [[1inh|1inh]], [[1inv|1inv]], [[1inw|1inw]], [[1inx|1inx]], [[1iny|1iny]], [[1ivb|1ivb]], [[1ivc|1ivc]], [[1ivd|1ivd]], [[1ive|1ive]], [[1ivf|1ivf]], [[1ivg|1ivg]], [[1kit|1kit]], [[1l7f|1l7f]], [[1l7g|1l7g]], [[1l7h|1l7h]], [[1mwe|1mwe]], [[1nca|1nca]], [[1ncb|1ncb]], [[1ncc|1ncc]], [[1ncd|1ncd]], [[1nma|1nma]], [[1nmb|1nmb]], [[1nmc|1nmc]], [[1nn2|1nn2]], [[1nna|1nna]], [[1nnb|1nnb]], [[1nnc|1nnc]], [[1nsb|1nsb]], [[1nsc|1nsc]], [[1nsd|1nsd]], [[1usr|1usr]], [[1usx|1usx]], [[1v2i|1v2i]], [[1v3b|1v3b]], [[1v3c|1v3c]], [[1v3d|1v3d]], [[1v3e|1v3e]], [[1vcj|1vcj]], [[1w1x|1w1x]], [[1w20|1w20]], [[1v0z|1v0z]], [[1w8n|1w8n]], [[1w8o|1w8o]], [[1xoe|1xoe]], [[1xog|1xog]], [[1z4v|1z4v]], [[1z4w|1z4w]], [[1z4x|1z4x]], [[1z4y|1z4y]], [[1z4z|1z4z]], [[1z50|1z50]], [[2bat|2bat]], [[2qwa|2qwa]], [[2qwb|2qwb]], [[2qwc|2qwc]], [[2qwd|2qwd]], [[2qwe|2qwe]], [[2qwf|2qwf]], [[2qwg|2qwg]], [[2qwh|2qwh]], [[2qwi|2qwi]], [[2qwj|2qwj]], [[2qwk|2qwk]], [[2sil|2sil]], [[2sim|2sim]], [[3nn9|3nn9]], [[4nn9|4nn9]], [[5nn9|5nn9]], [[6nn9|6nn9]], [[7nn9|7nn9]]</td></tr>
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<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Exo-alpha-sialidase Exo-alpha-sialidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.18 3.2.1.18] </span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Exo-alpha-sialidase Exo-alpha-sialidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.18 3.2.1.18] </span></td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1w21 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w21 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1w21 RCSB], [http://www.ebi.ac.uk/pdbsum/1w21 PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1w21 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w21 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1w21 RCSB], [http://www.ebi.ac.uk/pdbsum/1w21 PDBsum]</span></td></tr>
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<table>
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</table>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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[[Category: Exo-alpha-sialidase]]
[[Category: Exo-alpha-sialidase]]
[[Category: Influenza a virus]]
[[Category: Influenza a virus]]
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[[Category: Crennell, S J.]]
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[[Category: Crennell, S J]]
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[[Category: Garman, E F.]]
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[[Category: Garman, E F]]
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[[Category: Laver, W G.]]
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[[Category: Laver, W G]]
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[[Category: Rudino-Pinera, E.]]
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[[Category: Rudino-Pinera, E]]
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[[Category: Tunnah, P.]]
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[[Category: Tunnah, P]]
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[[Category: Webster, R G.]]
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[[Category: Webster, R G]]
[[Category: Hb site]]
[[Category: Hb site]]
[[Category: Hydrolase]]
[[Category: Hydrolase]]

Revision as of 12:25, 6 January 2015

STRUCTURE OF NEURAMINIDASE FROM ENGLISH DUCK SUBTYPE N6 COMPLEXED WITH 30 MM SIALIC ACID (NANA, NEU5AC), CRYSTAL SOAKED FOR 43 HOURS AT 291 K.

1w21, resolution 2.08Å

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