1t8t
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1t8t]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T8T OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1T8T FirstGlance]. <br> | <table><tr><td colspan='2'>[[1t8t]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T8T OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1T8T FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=A3P:ADENOSINE-3-5-DIPHOSPHATE'>A3P</scene>, <scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=A3P:ADENOSINE-3-5-DIPHOSPHATE'>A3P</scene>, <scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1s6t|1s6t]], [[1hy3|1hy3]], [[1bfb|1bfb]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1s6t|1s6t]], [[1hy3|1hy3]], [[1bfb|1bfb]]</td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">h3-OST-3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">h3-OST-3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1t8t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t8t OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1t8t RCSB], [http://www.ebi.ac.uk/pdbsum/1t8t PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1t8t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t8t OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1t8t RCSB], [http://www.ebi.ac.uk/pdbsum/1t8t PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/HS3SB_HUMAN HS3SB_HUMAN]] Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to an N-unsubstituted glucosamine linked to a 2-O-sulfo iduronic acid unit on heparan sulfate. Catalyzes the O-sulfation of glucosamine in IdoUA2S-GlcNS and also in IdoUA2S-GlcNH2. The substrate-specific O-sulfation generates an enzyme-modified heparan sulfate which acts as a binding receptor to Herpes simplex virus-1 (HSV-1) and permits its entry. Unlike 3-OST-1, does not convert non-anticoagulant heparan sulfate to anticoagulant heparan sulfate.<ref>PMID:10520990</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Edavettal, S C | + | [[Category: Edavettal, S C]] |
| - | [[Category: Krahn, J M | + | [[Category: Krahn, J M]] |
| - | [[Category: Linhardt, R J | + | [[Category: Linhardt, R J]] |
| - | [[Category: Liu, J | + | [[Category: Liu, J]] |
| - | [[Category: Moon, A F | + | [[Category: Moon, A F]] |
| - | [[Category: Munoz, E M | + | [[Category: Munoz, E M]] |
| - | [[Category: Negishi, M | + | [[Category: Negishi, M]] |
| - | [[Category: Pedersen, L C | + | [[Category: Pedersen, L C]] |
[[Category: Alpha-beta motif]] | [[Category: Alpha-beta motif]] | ||
[[Category: Substrate-binding cleft]] | [[Category: Substrate-binding cleft]] | ||
[[Category: Transferase]] | [[Category: Transferase]] | ||
Revision as of 14:50, 24 December 2014
Crystal Structure of human 3-O-Sulfotransferase-3 with bound PAP
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