2qro
From Proteopedia
(Difference between revisions)
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2qro FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qro OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2qro RCSB], [http://www.ebi.ac.uk/pdbsum/2qro PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2qro FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qro OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2qro RCSB], [http://www.ebi.ac.uk/pdbsum/2qro PDBsum]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/DCK_HUMAN DCK_HUMAN]] Required for the phosphorylation of the deoxyribonucleosides deoxycytidine (dC), deoxyguanosine (dG) and deoxyadenosine (dA). Has broad substrate specificity, and does not display selectivity based on the chirality of the substrate. It is also an essential enzyme for the phosphorylation of numerous nucleoside analogs widely employed as antiviral and chemotherapeutic agents.<ref>PMID:18377927</ref> <ref>PMID:20614893</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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[[Category: Deoxycytidine kinase]] | [[Category: Deoxycytidine kinase]] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Ealick, S E | + | [[Category: Ealick, S E]] |
| - | [[Category: Soriano, E V | + | [[Category: Soriano, E V]] |
[[Category: Atp-binding]] | [[Category: Atp-binding]] | ||
[[Category: Deoxyadenosine monophosphate]] | [[Category: Deoxyadenosine monophosphate]] | ||
| - | [[Category: Deoxycytidine kinase]] | ||
[[Category: Nucleotide-binding]] | [[Category: Nucleotide-binding]] | ||
[[Category: Nucleus]] | [[Category: Nucleus]] | ||
Revision as of 05:53, 25 December 2014
Human Deoxycytidine kinase dAMP, UDP, Mg ion product complex
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