Molecular Playground/Insulin

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* Insulin
* Insulin
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** [[3i3z]], [[3i40]], [[3e7y]], [[3e7z]], [[2qiu]], [[2c8q]], [[2c8r]], [[1q4v]], [[1os3]], [[1os4]], [[1mso]], [[1guj]], [[1g7a]], [[1g7b]], [[1xda]], [[1trz]], [[3zqr]], [[3zs2]], [[3zu1]], [[2lgb]], [[3v19]], [[3v1g]], [[4ajx]], [[4ajz]], [[4ak0]], [[4akj]], [[4eww]], [[4ewx]], [[4ewz]], [[4ex0]], [[4ex1]], [[4exx]], [[4ey1]], [[4ey9]], [[4eyd]], [[4eyn]], [[4eyp]], [[4f0n]], [[4f0o]], [[4f1a]], [[4f1b]], [[4f1c]], [[4f1d]], [[4f1f]], [[4f1g]], [[4f4t]], [[4f4v]], [[4f51]], [[4f8f]], [[4fg3]], [[4fka]], [[4gbc]], [[4gbi]], [[4gbk]], [[4gbl]], [[4gbn]], [[2m1d]], [[4iyd]], [[4iyf]] - hIns A chain + B chain – human <BR />
+
** [[3i3z]], [[3i40]], [[3e7y]], [[3e7z]], [[2qiu]], [[2c8q]], [[2c8r]], [[1q4v]], [[1os3]], [[1os4]], [[1mso]], [[1guj]], [[1g7a]], [[1g7b]], [[1xda]], [[1trz]], [[3zqr]], [[3zs2]], [[3zu1]], [[2lgb]], [[3v19]], [[3v1g]], [[4ajx]], [[4ajz]], [[4ak0]], [[4akj]], [[4eww]], [[4ewx]], [[4ewz]], [[4ex0]], [[4ex1]], [[4exx]], [[4ey1]], [[4ey9]], [[4eyd]], [[4eyn]], [[4eyp]], [[4f0n]], [[4f0o]], [[4f1a]], [[4f1b]], [[4f1c]], [[4f1d]], [[4f1f]], [[4f1g]], [[4f4t]], [[4f4v]], [[4f51]], [[4f8f]], [[4fg3]], [[4fka]], [[4gbc]], [[4gbi]], [[4gbk]], [[4gbl]], [[4gbn]], [[2m1d]], [[4iyd]], [[4iyf]], [[2mli]], [[4p65]], [[4rxw]], [[2w44]], [[3jsd]], [[2vjz]], [[2vk0]], [[1uz9]], [[3p33]], [[3w7y]], [[3w7z]], [[3w80]], [[4xc4]] - hIns A chain + B chain – human <BR />
** [[1fu2]], [[1fub]] - hIns A chain + B chain – powder diffraction <BR />
** [[1fu2]], [[1fub]] - hIns A chain + B chain – powder diffraction <BR />
** [[2kxk]], [[3bxq]], [[1b9e]], [[3rov]], [[3u4n]], [[4iuz]], [[2m1e]], [[2m2m]], [[2m2n]], [[2m2o]], [[2m2p]] – hIns A chain + B chain (mutant) <BR />
** [[2kxk]], [[3bxq]], [[1b9e]], [[3rov]], [[3u4n]], [[4iuz]], [[2m1e]], [[2m2m]], [[2m2n]], [[2m2o]], [[2m2p]] – hIns A chain + B chain (mutant) <BR />
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** [[3ir0]], [[3inc]], [[3ilg]], [[3kq6]], [[3exx]], [[2r34]], [[2r35]], [[2r36]], [[3tt8]] - hIns A chain + B chain + non-Zn metal ion<BR />
** [[3ir0]], [[3inc]], [[3ilg]], [[3kq6]], [[3exx]], [[2r34]], [[2r35]], [[2r36]], [[3tt8]] - hIns A chain + B chain + non-Zn metal ion<BR />
** [[3fq9]], [[1xw7]], [[1rwe]], [[1jca]], [[1j73]], [[4efx]] - hIns A chain (mutant) + B chain <BR />
** [[3fq9]], [[1xw7]], [[1rwe]], [[1jca]], [[1j73]], [[4efx]] - hIns A chain (mutant) + B chain <BR />
-
** [[1w8p]] - hIns A chain + B chain (mutant) <BR />
+
** [[1w8p]], [[4cxl]], [[4cxn]], [[4cy7]], [[4nib]], [[4une]], [[4ung]], [[4unh]], [[2wru]], [[2wrv]], [[2wrw]], [[2wrx]], [[2ws0]], [[2ws1]], [[2ws4]], [[2ws6]],[[ 2ws7]], [[1qj0]], [[3p2x]] - hIns A chain + B chain (mutant) <BR />
-
** [[2w44]] - hIns A chain residues 82-98 + B chain residues 25-53 <BR />
+
** [[3gky]], [[2g4m]], [[1zni]], [[1znj]], [[1wav]], [[1iza]], [[1izb]], [[9ins]], [[4ins]], [[3ins]], [[3t2a]], [[4a7e]], [[3rto]], [[3fhp]] - pIns A chain + B chain – pig<BR />
-
** [[2wru]], [[2wrv]], [[2wrw]], [[2wrx]], [[2ws0]], [[2ws1]], [[2ws4]], [[2ws6]], [[2ws7]], [[1qj0]] - hIns A chain + B chain residues 25-54 (mutant) <BR />
+
-
** [[3jsd]], [[2vjz]], [[2vk0]], [[1uz9]], [[3p33]], [[3w7y]], [[3w7z]], [[3w80]] - hIns A chain residues 90-110 + B chain residues 25-54<br />
+
-
** [[3p2x]] - hIns A chain residues 90-110 + B chain residues 25-54 (mutant) <br />
+
-
** [[3gky]], [[2g4m]], [[1zni]], [[1znj]], [[1wav]], [[1iza]], [[1izb]], [[9ins]], [[4ins]], [[3ins]], [[3t2a]], [[4a7e]] - pIns A chain + B chain – pig<BR />
+
** [[2zpp]], [[2efa]] - pIns A chain + B chain – Neutron <BR />
** [[2zpp]], [[2efa]] - pIns A chain + B chain – Neutron <BR />
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** [[2zp6]], [[1aph]], [[1bph]], [[1cph]], [[1dph]], [[4e7t]], [[4e7u]], [[4e7v]], [[4idw]], [[4bs3]], [[4i5y]], [[4i5z]], [[4ihn]], [[4m4f]], [[4m4h]], [[4m4i]], [[4m4j]], [[4m4l]], [[4m4m]] - bIns A chain + B chain – bovine <BR />
+
** [[2zp6]], [[1aph]], [[1bph]], [[1cph]], [[1dph]], [[4e7t]], [[4e7u]], [[4e7v]], [[4idw]], [[4bs3]], [[4i5y]], [[4i5z]], [[4ihn]], [[4m4f]], [[4m4h]], [[4m4i]], [[4m4j]], [[4m4l]], [[4m4m]], [[2a3g]], [[2bn1]], [[2bn3]] - bIns A chain + B chain – bovine <BR />
-
** [[2a3g]], [[2bn1]], [[2bn3]] - bIns A chain residues 85-105 + B chain residues 25-54 <br />
+
** [[3rto]], [[3fhp]] - pIns A chain + B chain <br />
-
** [[3rto]], [[3fhp]] - pIns A chain residues 88-108 + B chain residues 25-54 <br />
+
** [[1m5a]] - pIns A chain + B chain + non-Zn metal ion<BR />
** [[1m5a]] - pIns A chain + B chain + non-Zn metal ion<BR />
** [[6ins]] – pIns single chain
** [[6ins]] – pIns single chain
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* Insulin structures using NMR
* Insulin structures using NMR
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** [[1sf1]], [[2aiy]], [[3aiy]], [[4aiy]], [[5aiy]], [[1ai0]], [[1aiy]], [[1xgl]], [[1hiq]], [[1hit]] - hIns A chain + B chain – NMR<BR />
+
** [[1sf1]], [[2aiy]], [[3aiy]], [[4aiy]], [[5aiy]], [[1ai0]], [[1aiy]], [[1xgl]], [[1hiq]], [[1hit]], [[2mpg]], [[2mvc]] - hIns A chain + B chain – NMR<BR />
** [[2hiu]] – apo-hIns A chain + B chain – NMR<BR />
** [[2hiu]] – apo-hIns A chain + B chain – NMR<BR />
-
** [[2kqq]], [[1t1k]], [[1t1p]], [[1t1q]] - hIns A chain (mutant) + B chain – NMR<BR />
+
** [[2kqq]], [[1t1k]], [[1t1p]], [[1t1q]], [[2mpi]], [[2l1y]], [[2l1z]] - hIns A chain (mutant) + B chain – NMR<BR />
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** [[2jmn]], [[2h67]], [[2hh4]], [[2hho]], [[1jco]], [[1a7f]] - hIns A chain + B chain (mutant) – NMR<BR />
+
** [[2jmn]], [[2h67]], [[2hh4]], [[2hho]], [[1jco]], [[1a7f]], [[2mvd]], [[2kjj]], [[2kju]], [[2k91]], [[2k9r]], [[2rn5]] - hIns A chain + B chain (mutant) – NMR<BR />
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** [[2jum]], [[2juu]], [[2juv]], [[1kmf]], [[1k3m]], [[1bzv]], [[1vkt]], [[1hui]], [[1mhi]], [[1mhj]], [[1hls]] - hIns A chain (mutant) + B chain (mutant) – NMR<BR />
+
** [[2jum]], [[2juu]], [[2juv]], [[1kmf]], [[1k3m]], [[1bzv]], [[1vkt]], [[1hui]], [[1mhi]], [[1mhj]], [[1hls]], [[1lkq]] - hIns A chain (mutant) + B chain (mutant) – NMR<BR />
-
** [[2l1y]], [[2l1z]] - hIns A chain residues 90-110 (mutant) + B chain residues 25-54 - NMR<br />
+
** [[2jv1]] – apo-hIns A chain + B chain (mutant) – NMR<BR />
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** [[2kjj]], [[2kju]], [[2k91]], [[2k9r]], [[2rn5]] - hIns A chain residues 90-110 + B chain residues 25-54 (mutant) – NMR<BR />
+
-
** [[1lkq]] - hIns A chain residues 90-110 (mutant) + B chain residues 25-54 (mutant) – NMR<BR />
+
-
** [[2jv1]] – apo-hIns A chain residues 90-110 + B chain residues 25-54 (mutant) – NMR<BR />
+
** [[2jzq]] - hIns A chain – NMR<BR />
** [[2jzq]] - hIns A chain – NMR<BR />
** [[1ho0]] - hIns B chain (mutant) – NMR<BR />
** [[1ho0]] - hIns B chain (mutant) – NMR<BR />
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** [[1jk8]] - hIns B chain peptide + HLA<BR />
** [[1jk8]] - hIns B chain peptide + HLA<BR />
** [[1zeg]], [[1lph]] - hIns A chain (mutant) + B chain (mutant) + phenol<br />
** [[1zeg]], [[1lph]] - hIns A chain (mutant) + B chain (mutant) + phenol<br />
-
** [[1qiy]] - hIns A chain + B chain residues 25-54 (mutant) + phenol<br />
+
** [[1qiy]] - hIns A chain + B chain (mutant) + phenol<br />
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** [[1qiz]] - hIns A chain + B chain residues 25-54 (mutant) + resorcinol<BR />
+
** [[1qiz]] - hIns A chain + B chain (mutant) + resorcinol<BR />
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** [[1ev3]], [[1ev6]] - hIns A chain residues 87-107 + B chain residues 25-54+ cresol<br />
+
** [[1ev3]], [[1ev6]] - hIns A chain + B chain+ cresol<br />
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** [[1evr]] - hIns A chain residues 87-107 + B chain residues 25-54+ resorcinol<BR />
+
** [[1evr]] - hIns A chain + B chain + resorcinol<BR />
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** [[3q6e]] - hIns A chain residues 90-110 + B chain residues 25-54+ synthetic receptor<BR />
+
** [[3q6e]] - hIns A chain + B chain + synthetic receptor<BR />
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** [[2g54]], [[2g56]] - hIns B chain residues 25-54 + insulin-degrading enzyme<br />
+
** [[2g54]], [[2g56]] - hIns B chain + insulin-degrading enzyme<br />
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** [[2wby]], [[2wc0]] - hIns A chain residues 90-109 + B chain residues 25-54 + insulin-degrading enzyme (mutant)<br />
+
** [[2wby]], [[2wc0]] - hIns A chain + B chain + insulin-degrading enzyme (mutant)<br />
** [[3w11]] - hIns A chain + B chain + insulin-degrading enzyme + antibody<br />
** [[3w11]] - hIns A chain + B chain + insulin-degrading enzyme + antibody<br />
 +
**[[4oga]] - hIns A chain + B chain + insulin receptor + antibody<br />
** [[1b17]], [[1b18]], [[1b19]], [[1b2a]], [[1b2b]], [[1b2c]], [[1b2d]], [[1b2e]], [[1b2f]], [[1b2g]] - pIns A chain + B chain + sulfate<BR />
** [[1b17]], [[1b18]], [[1b19]], [[1b2a]], [[1b2b]], [[1b2c]], [[1b2d]], [[1b2e]], [[1b2f]], [[1b2g]] - pIns A chain + B chain + sulfate<BR />
** [[1mpj]] - pIns A chain + B chain + phenol<br />
** [[1mpj]] - pIns A chain + B chain + phenol<br />

Revision as of 06:38, 27 April 2015

One of the CBI Molecules being studied in the University of Massachusetts Amherst Chemistry-Biology Interface Program at UMass Amherst in the Roberts Research Group and on display at the Molecular Playground.

Human insulin chain A (grey) and chain B (green), 3i40

Drag the structure with the mouse to rotate
For additional details see Insulin Structure & Function.


3D structures of Insulin (Updated on 27-April-2015)



Additional Resources

For additional information, see: Diabetes & Hypoglycemia

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