Spermidine/spermine N-acetyltransferase

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{{STRUCTURE_2jev| PDB=2jev | SIZE=400| SCENE= |right|CAPTION=Human SSAT1 dimer complex with acetyl-spermine-S-CoA, [[2jev]] }}
{{STRUCTURE_2jev| PDB=2jev | SIZE=400| SCENE= |right|CAPTION=Human SSAT1 dimer complex with acetyl-spermine-S-CoA, [[2jev]] }}
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== Function ==
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'''Spermidine/spermine N-acetyltransferase''' (SSAT) catalyzes the acetylation of spermidine and spermine. SSAT regulates cellular polyamine homeostasis by degrading polyamines via their acetylation. SSAT activity is regulated by polyamine concentration and various toxins, hormones and natural products<ref>PMID:18349109</ref>.
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== Relevance ==
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Several types of cancer are accompanied by increased level of cellular polyamine and compounds which affect SSAT activity are explored as possible anti-cancer drugs.
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'''Spermidine/spermine N-acetyltransferase''' (SSAT) catalyzes the acetylation of spermidine and spermine. SSAT regulates cellular polyamine homeostasis by degrading polyamines via their acetylation. SSAT activity is regulated by polyamine concentration and various toxins, hormones and natural products. Several types of cancer are accompanied by increased level of cellular polyamine and compounds which affect SSAT activity are explored as possible anti-cancer drugs.
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==3D structures of SSAT==
==3D structures of SSAT==
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**[[3bj8]] - hSSAT1 + spermine + CoA
**[[3bj8]] - hSSAT1 + spermine + CoA
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== References ==
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<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 07:00, 31 August 2016

Template:STRUCTURE 2jev

Contents

Function

Spermidine/spermine N-acetyltransferase (SSAT) catalyzes the acetylation of spermidine and spermine. SSAT regulates cellular polyamine homeostasis by degrading polyamines via their acetylation. SSAT activity is regulated by polyamine concentration and various toxins, hormones and natural products[1].

Relevance

Several types of cancer are accompanied by increased level of cellular polyamine and compounds which affect SSAT activity are explored as possible anti-cancer drugs.

3D structures of SSAT

31-August-2016

References

  1. ↑ Pegg AE. Spermidine/spermine-N(1)-acetyltransferase: a key metabolic regulator. Am J Physiol Endocrinol Metab. 2008 Jun;294(6):E995-1010. doi:, 10.1152/ajpendo.90217.2008. Epub 2008 Mar 18. PMID:18349109 doi:http://dx.doi.org/10.1152/ajpendo.90217.2008

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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