Sulfotransferase

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{{STRUCTURE_1hy3| PDB=1hy3 | SIZE=400| SCENE= |right|CAPTION=Human estrogen sulfotransferase dimer complex with cofactor PAP (stick model), [[1hy3]] }}
{{STRUCTURE_1hy3| PDB=1hy3 | SIZE=400| SCENE= |right|CAPTION=Human estrogen sulfotransferase dimer complex with cofactor PAP (stick model), [[1hy3]] }}
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== Function ==
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'''Sulfotransferase''' (ST) are enzymes which catalyze the transfer of a sulfate group from a donor molecule to an acceptor alcohol or amine. The acceptors are hormones, neurotransmitters, drugs and xenobiotic compounds. The addition of a charged chemical moiety to the above carbon-rich water-insoluble molecules, make them more soluble and thus transportable in the circulatory system<ref>PMID:20136513</ref>. The various human STs are named SULT### and differ in their tissue distribution and substrate specificities. The most common donor molecule is 3’-phosphoadenosine-5’-phosphosulfate (PAP).
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== Relevance ==
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Reduced level of ST expression and activity is observed in liver diseases<ref>PMID:23775849</ref>.
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'''Sulfotransferase''' (ST) are enzymes which catalyze the transfer of a sulfate group from a donor molecule to an acceptor alcohol or amine. The acceptors are hormones, neurotransmitters, drugs and xenobiotic compounds. The addition of a charged chemical moiety to the above carbon-rich water-insoluble molecules, make them more soluble and thus transportable in the circulatory system. The various human STs are named SULT### and differ in their tissue distribution and substrate specificities. The most common donor molecule is 3’-phosphoadenosine-5’-phosphosulfate (PAP).
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==3D structures of sulfotransferase==
==3D structures of sulfotransferase==
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**[[4mub]] – SmST + oxamniquine<br />
**[[4mub]] – SmST + oxamniquine<br />
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== References ==
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<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 10:21, 4 September 2016

Template:STRUCTURE 1hy3

Contents

Function

Sulfotransferase (ST) are enzymes which catalyze the transfer of a sulfate group from a donor molecule to an acceptor alcohol or amine. The acceptors are hormones, neurotransmitters, drugs and xenobiotic compounds. The addition of a charged chemical moiety to the above carbon-rich water-insoluble molecules, make them more soluble and thus transportable in the circulatory system[1]. The various human STs are named SULT### and differ in their tissue distribution and substrate specificities. The most common donor molecule is 3’-phosphoadenosine-5’-phosphosulfate (PAP).

Relevance

Reduced level of ST expression and activity is observed in liver diseases[2].

3D structures of sulfotransferase

Updated on 04-September-2016

References

  1. ↑ Malojcic G, Glockshuber R. The PAPS-independent aryl sulfotransferase and the alternative disulfide bond formation system in pathogenic bacteria. Antioxid Redox Signal. 2010 Oct;13(8):1247-59. doi: 10.1089/ars.2010.3119. PMID:20136513 doi:http://dx.doi.org/10.1089/ars.2010.3119
  2. ↑ Yalcin EB, More V, Neira KL, Lu ZJ, Cherrington NJ, Slitt AL, King RS. Downregulation of sulfotransferase expression and activity in diseased human livers. Drug Metab Dispos. 2013 Sep;41(9):1642-50. doi: 10.1124/dmd.113.050930. Epub 2013, Jun 17. PMID:23775849 doi:http://dx.doi.org/10.1124/dmd.113.050930

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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