3ipx
From Proteopedia
(Difference between revisions)
| Line 8: | Line 8: | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ipx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ipx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ipx RCSB], [http://www.ebi.ac.uk/pdbsum/3ipx PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ipx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ipx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ipx RCSB], [http://www.ebi.ac.uk/pdbsum/3ipx PDBsum]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/DCK_HUMAN DCK_HUMAN]] Required for the phosphorylation of the deoxyribonucleosides deoxycytidine (dC), deoxyguanosine (dG) and deoxyadenosine (dA). Has broad substrate specificity, and does not display selectivity based on the chirality of the substrate. It is also an essential enzyme for the phosphorylation of numerous nucleoside analogs widely employed as antiviral and chemotherapeutic agents.<ref>PMID:18377927</ref> <ref>PMID:20614893</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Revision as of 10:40, 25 December 2014
X-Ray structure of Human Deoxycytidine Kinase in complex with ADP and an inhibitor
| |||||||||||
