1y4m
From Proteopedia
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|PDB= 1y4m |SIZE=350|CAPTION= <scene name='initialview01'>1y4m</scene>, resolution 1.60Å | |PDB= 1y4m |SIZE=350|CAPTION= <scene name='initialview01'>1y4m</scene>, resolution 1.60Å | ||
|SITE= | |SITE= | ||
| - | |LIGAND= <scene name='pdbligand=CL:CHLORIDE ION'>CL</scene> | + | |LIGAND= <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= ERVFRDE1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]) | |GENE= ERVFRDE1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]) | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY=[[1mof|1MOF]] | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1y4m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y4m OCA], [http://www.ebi.ac.uk/pdbsum/1y4m PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1y4m RCSB]</span> | ||
}} | }} | ||
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[[Category: Rey, F A.]] | [[Category: Rey, F A.]] | ||
[[Category: Varela, P F.]] | [[Category: Varela, P F.]] | ||
| - | [[Category: CL]] | ||
[[Category: coat protein]] | [[Category: coat protein]] | ||
[[Category: endogenous retrovirus]] | [[Category: endogenous retrovirus]] | ||
[[Category: membrane fusion]] | [[Category: membrane fusion]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:58:43 2008'' |
Revision as of 21:58, 30 March 2008
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| , resolution 1.60Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | |||||||
| Gene: | ERVFRDE1 (Homo sapiens) | ||||||
| Related: | 1MOF
| ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Crystal structure of human endogenous retrovirus HERV-FRD envelope protein (syncitin-2)
Overview
HERV-FRD is a human endogenous retrovirus that entered the human genome 40 million years ago. Its envelope gene, syncytin-2, was diverted by an ancestral host most probably because of its fusogenic property, for a role in placenta morphogenesis. It was maintained in a functional state in all primate branches as a bona fide cellular gene, submitted to a very low mutation rate as compared to infectious retrovirus genomes. The structure of the syncytin-2 protein thus provides a good insight into that of the oldest mammalian retroviral envelope. Here, we report the crystal structure of a central fragment of its "fossil" ectodomain, allowing a remarkable superposition with the structures of the corresponding domains of present-day infectious retroviruses, in spite of a more than 60% divergent sequence. These results suggest the existence of a unique structural solution selected by these proteins for their fusogenic function.
About this Structure
1Y4M is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Crystal structure of a pivotal domain of human syncytin-2, a 40 million years old endogenous retrovirus fusogenic envelope gene captured by primates., Renard M, Varela PF, Letzelter C, Duquerroy S, Rey FA, Heidmann T, J Mol Biol. 2005 Oct 7;352(5):1029-34. PMID:16140326
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