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Journal:JBIC:30
From Proteopedia
(Difference between revisions)
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* Localization of Co ions associated with FXN: <scene name='69/696356/Cv/5'>chain A</scene>; <scene name='69/696356/Cv/7'>chain A rotated by 180°</scene>; <scene name='69/696356/Cv/8'>chain B</scene>. | * Localization of Co ions associated with FXN: <scene name='69/696356/Cv/5'>chain A</scene>; <scene name='69/696356/Cv/7'>chain A rotated by 180°</scene>; <scene name='69/696356/Cv/8'>chain B</scene>. | ||
* Localization of Eu ions associated with FXN: <scene name='69/696356/Cv/12'>chain A</scene>; <scene name='69/696356/Cv/13'>chain A rotated by 180°</scene>; <scene name='69/696356/Cv/14'>chain B</scene>; <scene name='69/696356/Cv/15'>chain B rotated by 180°</scene>. | * Localization of Eu ions associated with FXN: <scene name='69/696356/Cv/12'>chain A</scene>; <scene name='69/696356/Cv/13'>chain A rotated by 180°</scene>; <scene name='69/696356/Cv/14'>chain B</scene>; <scene name='69/696356/Cv/15'>chain B rotated by 180°</scene>. | ||
| + | Metal ions are represented as spheres, along with the side chains involved in metal coordination (using a distance cutoff of 3 Å). Protein chains are shown as ribbon models. | ||
The metals locate mainly in a region of high density of negative charge, the so-called "<scene name='69/696356/Cv/11'>acidic ridge</scene>", which is also the surface of interaction with the Fe-S cluster assembly machinery. No major changes occurs in FXN structures upon interaction with metals, when derivative structures are compared with the previously determined apo form (PDB ID: 4HS5), but subtle changes in crystallographic B-factors occur in two regions of the protein not in direct contact with metals. This changes suggest localized changes in internal motions, with potential impact in interaction with partner proteins. | The metals locate mainly in a region of high density of negative charge, the so-called "<scene name='69/696356/Cv/11'>acidic ridge</scene>", which is also the surface of interaction with the Fe-S cluster assembly machinery. No major changes occurs in FXN structures upon interaction with metals, when derivative structures are compared with the previously determined apo form (PDB ID: 4HS5), but subtle changes in crystallographic B-factors occur in two regions of the protein not in direct contact with metals. This changes suggest localized changes in internal motions, with potential impact in interaction with partner proteins. | ||
</StructureSection> | </StructureSection> | ||
Revision as of 08:55, 15 March 2015
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- ↑ REF
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