Sandbox Reserved 1086
From Proteopedia
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Green fluorescent protein ('''GFP'''), originally isolated from the jellyfish ''Aequorea victoria'' (PDB entry [[1ema]]), fluorsceses green (509nm) when exposed to blue light (395nm and 475nm). It is one of the most important proteins used in biological research because it can be used to tag otherwise invisible gene products of interest and thus observe their existence, location and movement. | Green fluorescent protein ('''GFP'''), originally isolated from the jellyfish ''Aequorea victoria'' (PDB entry [[1ema]]), fluorsceses green (509nm) when exposed to blue light (395nm and 475nm). It is one of the most important proteins used in biological research because it can be used to tag otherwise invisible gene products of interest and thus observe their existence, location and movement. | ||
Exploring the Structure | Exploring the Structure | ||
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== Exploring the Structure == | == Exploring the Structure == | ||
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This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes. | This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes. | ||
| - | + | [[Image: Abspregram.png|thumb|right|350px|Abspregram of the 151 species]] | |
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== Structural highlights == | == Structural highlights == | ||
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1q5a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1q5a OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1q5a RCSB], [http://www.ebi.ac.uk/pdbsum/1q5a PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1q5a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1q5a OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1q5a RCSB], [http://www.ebi.ac.uk/pdbsum/1q5a PDBsum]</span></td></tr> | ||
</table> | </table> | ||
| - | [[Image: Abspregram.png|thumb| | + | [[Image: Abspregram.png|thumb|right|350px|Abspregram of the 151 species]] |
== References == | == References == | ||
<references/> | <references/> | ||
Revision as of 11:54, 20 April 2015
| This Sandbox is Reserved from 15/04/2015, through 15/06/2015 for use in the course "Protein structure, function and folding" taught by Taru Meri at the University of Helsinki. This reservation includes Sandbox Reserved 1081 through Sandbox Reserved 1090. |
To get started:
More help: Help:Editing |
Contents |
C-cadherin
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Exploring the Structure
GFP is a beta barrel protein with 11 beta sheets. It is a 26.9kDa protein made up of 238 amino acids. The chromophore, responsible for the fluorescent properties of the protein, is buried inside the beta barrel as part of the central alpha helix passing through the barrel. The forms via spontaneous cyclization and oxidation of three residues in the central alpha helix: -Thr65 (or Ser65)-Tyr66-Gly67. This cyclization and oxidation creates the chromophore's five-membered ring via a new bond between the threonine and the glycine residues [1].
This is a sample scene created with SAT to by Group, and another to make of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.
Image:Abspregram.png
Abspregram of the 151 species
Structural highlights
| 1q5a is a 2 chain structure with sequence from Mus musculus. The March 2008 RCSB PDB Molecule of the Month feature on Cadherin by David S. Goodsell is 10.2210/rcsb_pdb/mom_2008_3. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. | |
| Ligands: | , , |
| Related: | 1l3w, 1q55, 1q5b, 1q5c |
| Resources: | FirstGlance, OCA, RCSB, PDBsum |
Image:Abspregram.png
Abspregram of the 151 species
