Methyl CpG binding protein
From Proteopedia
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== Function == | == Function == | ||
| - | '''Methyl CpG binding proteins''' are called MBD1 to MBD4 and contain a methyl-CpG binding domain (MBD) which binds to methylated DNA.<br /> | + | '''Methyl CpG binding proteins''' are called MBD1 to MBD4 and contain a methyl-CpG binding domain (MBD) which binds to methylated DNA<ref>PMID:11746232</ref>.<br /> |
• '''MBD1''' is a transcription regulator. It reverts methylated cytosine bases to cytosine.<br /> | • '''MBD1''' is a transcription regulator. It reverts methylated cytosine bases to cytosine.<br /> | ||
• '''MBD2''' is part of the MeCP1 complex which contains also NuRD. MBD2 recruits histone deacetylases and DNA methyltransferases. MBD2 functions as a scaffold protein promoting repression.<br /> | • '''MBD2''' is part of the MeCP1 complex which contains also NuRD. MBD2 recruits histone deacetylases and DNA methyltransferases. MBD2 functions as a scaffold protein promoting repression.<br /> | ||
• '''MBD3''' binds to hydroxymethylated DNA.<br /> | • '''MBD3''' binds to hydroxymethylated DNA.<br /> | ||
| - | • '''MBD4''' has a G:T | + | • '''MBD4''' has a G:T mispair-specific activity.<br /> |
• '''Methyl CpG binding protein 2''' (MeCP2) is present in mature nerve cells and is involved in turning off several genes. For more details see [[Methyl CpG Binding Protein 2]].<br /> | • '''Methyl CpG binding protein 2''' (MeCP2) is present in mature nerve cells and is involved in turning off several genes. For more details see [[Methyl CpG Binding Protein 2]].<br /> | ||
== Disease == | == Disease == | ||
| + | Mutations in MBD2 are involved in Rett syndrome<ref>PMID:11738862</ref>. | ||
== Relevance == | == Relevance == | ||
| - | + | MBD1 has a role in lung, prostate, pancreatic, colorectal cancers and promyelocytic leukemia. MBD2 has a role in lung, prostate, renal, colorectal cancers. MBD3 has a role in lung, prostate, ovarian cancers and promyelocytic leukemia. MBD4 has a role in gastric, liver and colorectal cancers. | |
== Structural highlights == | == Structural highlights == | ||
</StructureSection> | </StructureSection> | ||
Revision as of 07:35, 24 April 2016
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3D structures of methyl CpG binding protein
Updated on 24-April-2016
References
- ↑ Wade PA. Methyl CpG-binding proteins and transcriptional repression. Bioessays. 2001 Dec;23(12):1131-7. PMID:11746232 doi:http://dx.doi.org/10.1002/bies.10008
- ↑ Van den Veyver IB, Zoghbi HY. Mutations in the gene encoding methyl-CpG-binding protein 2 cause Rett syndrome. Brain Dev. 2001 Dec;23 Suppl 1:S147-51. PMID:11738862
