Sandbox-insulin-ben
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===מבנה ראשוני של חלבון=== | ===מבנה ראשוני של חלבון=== | ||
| - | + | {{Main|Protein primary structure|Nucleic acid primary structure}} | |
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| - | + | In [[biochemistry]], the '''primary structure''' of a biological molecule is the exact specification of its atomic composition and the chemical bonds connecting those atoms (including [[stereochemistry]]). For a typical unbranched, un-crosslinked [[biopolymer]] (such as a [[molecule]] of [[DNA]], [[RNA]], or typical intracellular [[protein]]), the primary structure is equivalent to specifying the sequence of its [[monomer]]ic subunits, e.g., the [[nucleotide sequence|nucleotide]] or [[peptide sequence]]. | |
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| - | + | Primary structure is sometimes mistakenly termed ''primary sequence'', but there is no such term, as well as no parallel concept of secondary or tertiary sequence. By convention, the primary structure of a protein is reported starting from the amino-terminal (N) end to the carboxyl-terminal (C) end, while the primary structure of DNA or RNA molecule is reported from the 5' end to the 3' end. | |
| - | + | The primary structure of a nucleic acid molecule refers to the exact sequence of nucleotides that comprise the whole molecule. Frequently, the primary structure encodes [[Sequence motif|motifs]] that are of functional importance. Some examples of sequence motifs are: the C/D<!-- | |
| - | + | --><ref>{{cite journal | last = Samarsky | first = DA |author2=Fournier MJ|author3=Singer RH|author4=Bertrand E | year = 1998 | title = The snoRNA box C/D motif directs nucleolar targeting and also couples snoRNA synthesis and localization | journal = EMBO | volume = 17 | pages = 3747–3757 | pmid = 9649444 | doi = 10.1093/emboj/17.13.3747 | issue = 13 | pmc = 1170710 }}</ref> | |
| - | + | and H/ACA boxes<!-- | |
| - | + | --><ref>{{cite doi|10.1101/gad.11.7.941}}</ref> | |
| - | + | of [[snoRNA]]s, [[LSm|Sm binding site]] found in spliceosomal RNAs such as [[U1 spliceosomal RNA|U1]], [[U2 spliceosomal RNA|U2]], [[U4 spliceosomal RNA|U4]], [[U5 spliceosomal RNA|U5]], [[U6 spliceosomal RNA|U6]], [[U12 minor spliceosomal RNA|U12]] and [[Small nucleolar RNA U3|U3]], the [[Shine-Dalgarno sequence]],<!-- | |
| - | + | --><ref>{{cite journal |author=Shine J, Dalgarno L |title=Determinant of cistron specificity in bacterial ribosomes |journal=Nature |volume=254 |issue=5495 |pages=34–8 |year=1975 |pmid=803646 |doi=10.1038/254034a0|bibcode = 1975Natur.254...34S }}</ref> | |
| - | + | the [[Kozak consensus sequence]]<!-- | |
| + | --><ref name="Kozak1987">{{cite journal |author=Kozak M |title=An analysis of 5'-noncoding sequences from 699 vertebrate messenger RNAs |journal=Nucleic Acids Res. |volume=15 |issue=20 |pages=8125–8148 |date=October 1987 |pmid=3313277 |pmc=306349 |doi= 10.1093/nar/15.20.8125|url=http://nar.oxfordjournals.org/cgi/pmidlookup?view=long&pmid=3313277}}</ref> | ||
| + | and the [[RNA polymerase III|RNA polymerase III terminator]]<!-- | ||
| + | -->.<ref name="pmid6263489">{{cite journal |author=Bogenhagen DF, Brown DD |title=Nucleotide sequences in Xenopus 5S DNA required for transcription termination |journal=Cell |volume=24 |issue=1 |pages=261–70 |year=1981 |pmid=6263489 |doi=10.1016/0092-8674(81)90522-5}}</ref> | ||
===מבנה שניוני של חלבון=== | ===מבנה שניוני של חלבון=== | ||
Revision as of 08:29, 11 June 2015
קורס חלבונים מבנה וקישור תכנית רוטשילד ויצמן
מרצה:שירלי דאובה
Contents |
מבנה הקורס
מבנה ראשוני של חלבון
In biochemistry, the primary structure of a biological molecule is the exact specification of its atomic composition and the chemical bonds connecting those atoms (including stereochemistry). For a typical unbranched, un-crosslinked biopolymer (such as a molecule of DNA, RNA, or typical intracellular protein), the primary structure is equivalent to specifying the sequence of its monomeric subunits, e.g., the nucleotide or peptide sequence.
Primary structure is sometimes mistakenly termed primary sequence, but there is no such term, as well as no parallel concept of secondary or tertiary sequence. By convention, the primary structure of a protein is reported starting from the amino-terminal (N) end to the carboxyl-terminal (C) end, while the primary structure of DNA or RNA molecule is reported from the 5' end to the 3' end.
The primary structure of a nucleic acid molecule refers to the exact sequence of nucleotides that comprise the whole molecule. Frequently, the primary structure encodes motifs that are of functional importance. Some examples of sequence motifs are: the C/D[1] and H/ACA boxes[2] of snoRNAs, Sm binding site found in spliceosomal RNAs such as U1, U2, U4, U5, U6, U12 and U3, the Shine-Dalgarno sequence,[3] the Kozak consensus sequence[4] and the RNA polymerase III terminator.[5]
מבנה שניוני של חלבון
מבנה שלישוני של חלבון
חלק 1
חלק 2
חלק3
מבנה רביעוני
קואופרטיביות ואלוסטריה והסיפור של המוגלובין
קביעת מבנה - שיטות לאנליזה של חלבונים
סיפור האינסולין
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3D structures of Insulin (Updated on 11-June-2015)
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