Virus protease
From Proteopedia
(Difference between revisions)
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| - | {{STRUCTURE_1odw| PDB=1odw | SIZE= | + | {{STRUCTURE_1odw| PDB=1odw | SIZE=350| SCENE=Virus_protease/Cv/1 |right|CAPTION=HIV-1 protease dimer complex with tert-butylcarbonate [[1odw]] }} |
'''Virus proteases''' include HIV protease, XMRV protease, retropepsin. | '''Virus proteases''' include HIV protease, XMRV protease, retropepsin. | ||
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**[[1odx]], [[2hb2]], [[2hb4]], [[2pc0]], [[3bva]], [[3mws]], [[3kt2]], [[3kt5]], [[4ej8]], [[4ejl]] - HIV1-PR (mutant) <br /> | **[[1odx]], [[2hb2]], [[2hb4]], [[2pc0]], [[3bva]], [[3mws]], [[3kt2]], [[3kt5]], [[4ej8]], [[4ejl]] - HIV1-PR (mutant) <br /> | ||
**[[1rpi]], [[1rq9]], [[1tw7]], [[3oq7]], [[3oqa]], [[3oqd]], [[3pj6]], [[3uf3]], [[3o99]], [[3o9a]], [[3o9b]], [[3o9c]], [[3o9d]], [[3o9e]], [[3o9f]], [[3o9g]], [[3o9h]], [[3o9i]], [[3u71]] - HIV1-PR (drug-resistant mutant) <br /> | **[[1rpi]], [[1rq9]], [[1tw7]], [[3oq7]], [[3oqa]], [[3oqd]], [[3pj6]], [[3uf3]], [[3o99]], [[3o9a]], [[3o9b]], [[3o9c]], [[3o9d]], [[3o9e]], [[3o9f]], [[3o9g]], [[3o9h]], [[3o9i]], [[3u71]] - HIV1-PR (drug-resistant mutant) <br /> | ||
| - | **[[1odw]], [[ | + | **[[1odw]], [[4e43]], [[3hvp]], [[3phv]] - HIV1-PR<br /> |
**[[3fsm]], [[3hlo]] - HIV1-PR covalent dimer | **[[3fsm]], [[3hlo]] - HIV1-PR covalent dimer | ||
*HIV-1 protease complexes | *HIV-1 protease complexes | ||
| - | **[[1hsg]], [[1hsh]], [[1hsi]], [[3oxc]], [[3ekv]], [[3ekx]], [[3eky]], [[3el1]], [[1ohr]], [[3ndt]], [[3nls]], [[ | + | **[[1hsg]], [[1hsh]], [[1hsi]], [[3oxc]], [[3ekv]], [[3ekx]], [[3eky]], [[3el1]], [[1ohr]], [[3ndt]], [[3nls]], [[4ll3]], [[3ndu]], [[3ndw]], [[3ndx]], [[3r0w]], [[3r0y]], [[4dqb]], [[4jec]], [[4hla]] - HIV1-PR + antiviral drug<br /> |
**[[4eyr]], [[4j54]], [[4j55]], [[4j5j]] - HIV1-PR (mutant) + antiviral drug<br /> | **[[4eyr]], [[4j54]], [[4j55]], [[4j5j]] - HIV1-PR (mutant) + antiviral drug<br /> | ||
**[[1aid]], [[1qbr]], [[1qbs]], [[1qbt]], [[1qbu]], [[3mxe]], [[3m9f ]], [[3kf0]], [[3kf1]], [[3kfn]], [[3kfp]], [[3kfr]], [[3kfs]], [[2wkz]], [[2wl0]], [[3gga]], [[3ggv]], [[3ggx]], [[2uxz]], [[2uy0]], [[1zp8]], [[1xl2]], [[1xl5]], [[1zpa]], [[1yt9]], [[2a4f]], [[1upj]], [[2upj]], [[7upj]], [[1hxb]], [[1hih]], [[1hvr]], [[1hef]], [[1heg]], [[4phv]], [[1w5w]], [[1w5x]], [[1w5v]], [[1w5y]], [[1t7k]], [[1npa]], [[1npv]], [[1npw]], [[1eby]], [[1ec0]], [[1g2k]], [[1c6x]], [[1c6y]], [[1c6z]], [[1hwr]], [[2bpv]], [[2bpw]], [[2bpx]], [[ 2bpy]], [[ 2bpz]], [[ 1ody]], [[1hvh]], [[3tlh]], [[1hxw]], [[3bvb]], [[3ckt]], [[3mxd]], [[3hau]], [[3haw]], [[3hbo]], [[3hdk]], [[3i2l]], [[3ia9]], [[3r4b]], [[3bgb]], [[3bgc]], [[3bhe]], [[3gi4]], [[3gi5]], [[3gi6]], [[3nwq]], [[3nwx]], [[3nyg]], [[3psu]], [[3t11]], [[4fe6]], [[4a4q]], [[4i8w]], [[4i8z]] - HIV1-PR + inhibitor<br /> | **[[1aid]], [[1qbr]], [[1qbs]], [[1qbt]], [[1qbu]], [[3mxe]], [[3m9f ]], [[3kf0]], [[3kf1]], [[3kfn]], [[3kfp]], [[3kfr]], [[3kfs]], [[2wkz]], [[2wl0]], [[3gga]], [[3ggv]], [[3ggx]], [[2uxz]], [[2uy0]], [[1zp8]], [[1xl2]], [[1xl5]], [[1zpa]], [[1yt9]], [[2a4f]], [[1upj]], [[2upj]], [[7upj]], [[1hxb]], [[1hih]], [[1hvr]], [[1hef]], [[1heg]], [[4phv]], [[1w5w]], [[1w5x]], [[1w5v]], [[1w5y]], [[1t7k]], [[1npa]], [[1npv]], [[1npw]], [[1eby]], [[1ec0]], [[1g2k]], [[1c6x]], [[1c6y]], [[1c6z]], [[1hwr]], [[2bpv]], [[2bpw]], [[2bpx]], [[ 2bpy]], [[ 2bpz]], [[ 1ody]], [[1hvh]], [[3tlh]], [[1hxw]], [[3bvb]], [[3ckt]], [[3mxd]], [[3hau]], [[3haw]], [[3hbo]], [[3hdk]], [[3i2l]], [[3ia9]], [[3r4b]], [[3bgb]], [[3bgc]], [[3bhe]], [[3gi4]], [[3gi5]], [[3gi6]], [[3nwq]], [[3nwx]], [[3nyg]], [[3psu]], [[3t11]], [[4fe6]], [[4a4q]], [[4i8w]], [[4i8z]] - HIV1-PR + inhibitor<br /> | ||
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*HIV-1 protease (drug-resistant mutant) complexes | *HIV-1 protease (drug-resistant mutant) complexes | ||
| - | **[[3el4]], [[3el9]], [[3em3]], [[3em4]], [[3em6]], [[ | + | **[[3el4]], [[3el9]], [[3em3]], [[3em4]], [[3em6]], [[3u7s]], [[3ggu]], [[1t7j]], [[1rv7]], [[1n49]], [[1fb7]], [[3ekp]], [[3ekq]], [[3ekt]], [[3ekw]], [[3el0]], [[3el5]], [[3pwm]], [[3pwr]], [[3ucb]], [[3uhl]], [[3ttp]] - HIV1-PR (drug-resistant mutant) + antiviral drug<br /> |
**[[3ots]], [[3oty]], [[3ou1]], [[3ou3]], [[3ou4]], [[3oua]], [[3oub]], [[3ouc]], [[3oud]] - HIV1-PR (drug-resistant mutant) + peptide<br /> | **[[3ots]], [[3oty]], [[3ou1]], [[3ou3]], [[3ou4]], [[3oua]], [[3oub]], [[3ouc]], [[3oud]] - HIV1-PR (drug-resistant mutant) + peptide<br /> | ||
**[[1izh]], [[ 1izi]], [[1fb7]], [[3t3c]], [[4fae]], [[4faf]], [[3sa3]], [[3sa4]], [[3sa5]], [[3sa6]], [[3sa7]], [[3sa8]], [[3sa9]], [[3saa]], [[3sab]], [[3sac]], [[3vf5]], [[3vf7]], [[3vfa]], [[3vfb]] - HIV1-PR (drug-resistant mutant) + inhibitor<br /> | **[[1izh]], [[ 1izi]], [[1fb7]], [[3t3c]], [[4fae]], [[4faf]], [[3sa3]], [[3sa4]], [[3sa5]], [[3sa6]], [[3sa7]], [[3sa8]], [[3sa9]], [[3saa]], [[3sab]], [[3sac]], [[3vf5]], [[3vf7]], [[3vfa]], [[3vfb]] - HIV1-PR (drug-resistant mutant) + inhibitor<br /> | ||
Revision as of 10:34, 27 November 2016
Virus proteases include HIV protease, XMRV protease, retropepsin.
HIV Protease (HIV-PR) and xenotropic murine leukemia virus protease (XMRV-PR) cleave polyproteins to produce the mature proteins of the virus. Both are aspartyl proteases. The inhibition of HIV-PR results in an uninfectious HIV virion. HIV-1 is found globally while HIV-2, which has lower virulence, is found in West Africa.
See also
- Human Immunodeficiency Virus
- HIV-1 protease
- HIV Protease Inhibitor Pharmacokinetics
- HIV Protease Inhibitor Resistance Profile
- HIV Protease Resistance
- Molecular Playground/Dengue Virus Protease
- Viability of a drug-resistant HIV-1 protease mutant
- Molecular Playground/Dengue Virus Protease
3D Structures of Virus proteases
Updated on 27-November-2016
Proteopedia Page Contributors and Editors (what is this?)
Michal Harel, Alexander Berchansky, Joel L. Sussman, Jaime Prilusky
