4yia
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Structural mechanism of hormone release in thyroxine binding globulin== | |
| - | + | <StructureSection load='4yia' size='340' side='right' caption='[[4yia]], [[Resolution|resolution]] 1.58Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[4yia]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YIA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4YIA FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=IMN:INDOMETHACIN'>IMN</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr> | |
| - | [[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4yia FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yia OCA], [http://pdbe.org/4yia PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4yia RCSB], [http://www.ebi.ac.uk/pdbsum/4yia PDBsum]</span></td></tr> |
| + | </table> | ||
| + | == Disease == | ||
| + | [[http://www.uniprot.org/uniprot/THBG_HUMAN THBG_HUMAN]] Defects in SERPINA7 are a cause of thyroxine-binding globulin deficiency (TBG deficiency) [MIM:[http://omim.org/entry/314200 314200]]. Mutations in the SERPINA7 gene can result as a whole spectrum of deficiencies, characterized by either reduced or increased TBG levels in the serum. Patients show, respectively, reduced or elevated protein-bound iodine but are euthyroid. | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/THBG_HUMAN THBG_HUMAN]] Major thyroid hormone transport protein in serum. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Zheng, Y]] | [[Category: Zheng, Y]] | ||
| + | [[Category: Cation pi interaction]] | ||
| + | [[Category: Hormone release]] | ||
| + | [[Category: Serpin]] | ||
| + | [[Category: Signaling protein]] | ||
| + | [[Category: Thyroxine]] | ||
| + | [[Category: Thyroxine binding globulin]] | ||
Revision as of 15:18, 2 March 2016
Structural mechanism of hormone release in thyroxine binding globulin
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