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| - | ==Identification of a Water-Bridge Mediated Recognition Module at the mRNA Cap-Binding Interface of eIF4E==
| + | #REDIRECT [[5gw6]] This PDB entry is obsolete and replaced by 5gw6 |
| - | <StructureSection load='5abi' size='340' side='right' caption='[[5abi]], [[Resolution|resolution]] 1.97Å' scene=''>
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| - | == Structural highlights ==
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| - | <table><tr><td colspan='2'>[[5abi]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ABI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ABI FirstGlance]. <br>
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| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5abi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5abi OCA], [http://www.rcsb.org/pdb/explore.do?structureId=5abi RCSB], [http://www.ebi.ac.uk/pdbsum/5abi PDBsum]</span></td></tr>
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| - | </table>
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| - | == Function ==
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| - | [[http://www.uniprot.org/uniprot/IF4E_HUMAN IF4E_HUMAN]] Its translation stimulation activity is repressed by binding to the complex CYFIP1-FMR1 (By similarity). Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit mediates the binding to the mRNA cap.<ref>PMID:16271312</ref>
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| - | == References ==
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| - | <references/>
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| - | __TOC__
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| - | </StructureSection>
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| - | [[Category: Brown, C J]]
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| - | [[Category: Lama, D]]
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| - | [[Category: Verma, C S]]
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| - | [[Category: Cap binding]]
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| - | [[Category: Eif4e]]
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| - | [[Category: Protein translation]]
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| - | [[Category: Translation]]
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Current revision
- REDIRECT 5gw6 This PDB entry is obsolete and replaced by 5gw6
