Proton Channels
From Proteopedia
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<scene name='Proton_Channels/Gating/1'>His37 and Trp41</scene> are believed to be crucial for pH-dependent gating. | <scene name='Proton_Channels/Gating/1'>His37 and Trp41</scene> are believed to be crucial for pH-dependent gating. | ||
(The apparent collapse and re-expansion of their sidechains is an artifact due to the [[Morphs|linear interpolation method of morphing]].) Here are His and Trp <scene name='Proton_Channels/Gating/2'>spacefilled</scene>. | (The apparent collapse and re-expansion of their sidechains is an artifact due to the [[Morphs|linear interpolation method of morphing]].) Here are His and Trp <scene name='Proton_Channels/Gating/2'>spacefilled</scene>. | ||
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| + | To be explained in a later revision, along with new scenes: | ||
| + | [http://www.molmovdb.org/cgi-bin/morph.cgi?ID=b505428-6008 Morph from Yale] | ||
Revision as of 02:18, 27 March 2008
The M2 protein of influenza A virus is a proton channel. Its function is essential for productive infection by the virus.
See Category:Proton_channel for a list of all proton channel structures.
In January, 2008, crystallographic and NMR structures were published side by side in Nature for the transmembrane domains of the M2 protein: 3bkd to 2rlf. The former appeared to be in an open conformation blocked by amantadine, while the latter appeared to be in a closed conformation stabilized by rimantadine. (Neither drug is shown in the morph at right.)
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At right is a linear-interpolation morph between 3BKD and 2RLF, showing the proposed opening and closing of this channel.
In addition to watching the animation as alpha-helical ribbons, it is useful to watch it . Be sure to rotate the molecule with your mouse to watch the animation from different perspectives!
are believed to be crucial for pH-dependent gating. (The apparent collapse and re-expansion of their sidechains is an artifact due to the linear interpolation method of morphing.) Here are His and Trp .
To be explained in a later revision, along with new scenes: Morph from Yale
Proteopedia Page Contributors and Editors (what is this?)
Eric Martz, Eran Hodis, David Canner, Joel L. Sussman, Michal Harel, Alexander Berchansky, Jaime Prilusky
