Sandbox8999

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[[Link title]]==Clathrin==
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[[Clathrin]]
{{STRUCTURE_3lvg| PDB=3lvg | SIZE=400| SCENE= |right|CAPTION=Bovine clathrin heavy (grey, green, pink) and light (yellow, magenta, cyan) chains, [[3lvg]] }}
{{STRUCTURE_3lvg| PDB=3lvg | SIZE=400| SCENE= |right|CAPTION=Bovine clathrin heavy (grey, green, pink) and light (yellow, magenta, cyan) chains, [[3lvg]] }}

Revision as of 22:32, 12 November 2015

Clathrin Template:STRUCTURE 3lvg

Contents

History

The word clathrin originates from the Latin word clāthrāre, meaning “to provide with a lattice”. Clathrin is a protein involved in receptor-mediated endocytosis.1 It was not discovered until 1975 by Barbara Pearse, a British biological scientist. Clathrin is a protein resembling a triskelion shape and is composed of three heavy chains and three light chains which come together to form a polyhedral lattice similar to a cage. The three heavy chains resemble three legs protruding from a center point. Some of the major functions of clathrin include lysosomal targeting, receptor-mediated endocytosis, and organelle biogenesis from the trans-Golgi network.3 The polyhedral lattice shape of clathrin largely determines its functionality, in that there are many binding sites for proteins on the heavy chains of the lattice as well.[1]

Function

Disease

Relevance

Structural highlights

This is a sample scene created with SAT to by Group, and another to make of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.

</StructureSection>

References

  1. ↑ Ungewickell, E., & Brandon, D. (1981). Assembly units of clathrin coats. "Nature, 289, 420-422". doi: 10.1038/289420a0

4 Ungewickell, E., & Brandon, D. (1981). Assembly units of clathrin coats. Nature, 289, 420-422. doi: 10.1038/289420a0

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