Cardiotoxin

Function

Cardiotoxin (CTX) is a snake toxin from the Taiwan cobra Naja naja. The cardiotoxin from the Malayan krait is called bucain. CTX perturb the membrane structure of cells by interaction with lipids. ^[1] For toxins in Proteopedia see Toxins.

Relevance

Cardiotoxin I causes necrosis of skeletal muscle cells. Cardiotoxin III induces apoptosis in K562 cells.

3D Structures of Cardiotoxin

Updated on 20-November-2015

2cdx - NaCTX I – NMR – Naja atra

4om4 - NaCTX II
1cre, 1crf - NaCTX II – NMR
2ccx – NmCTX II – Naja mossambica – NMR
1cdt – NmCTX II
1ffj, 1cb9, 1ccq – CTX II – Naja oxiana – NMR
1i02, 2crs, 2crt - NaCTX III – NMR
1xt3, 1h0j – NaCTX III
4om5 - NaCTX IV
1kbs, 1kbt - NaCTX IV – NMR
1chv, 1cvo – NaCTX V – NMR
1kxi - NaCTX V
1ug4 – CTX VI
3plc – β-CTX – king cobra
1cxn, 1cxo, 1tgx – γ-CTX – Naja nigricollis - NMR
2h8u – Bucain
2bhi – CTX III+sulfogalactoceramide

References

1. ↑ Rees B, Samama JP, Thierry JC, Gilibert M, Fischer J, Schweitz H, Lazdunski M, Moras D. Crystal structure of a snake venom cardiotoxin. Proc Natl Acad Sci U S A. 1987 May;84(10):3132-6. PMID:3472200