Deoxycytidine kinase
From Proteopedia
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| - | <StructureSection load='1p61' size='350' side='right' caption='Mouse deoxycytidine kinase complex with ADP (stick model) | + | <StructureSection load='1p61' size='350' side='right' caption='Mouse deoxycytidine kinase complex with ADP (stick model) and deoxycytidine (stick models) (PDB entry [[1p61]])' scene=''> |
== Function == | == Function == | ||
| - | '''Deoxycytidine kinase''' (DCK) is required for the phosphorylation of deoxyribonucleosides dC, dG and dA and nucleosides analogs which are used as antiviral and chemotherapeutic agents. <ref>PMID:20614893</ref> | + | '''Deoxycytidine kinase''' (DCK) is required for the phosphorylation of deoxyribonucleosides dC, dG and dA (but not dT and dU) and nucleosides analogs which are used as antiviral and chemotherapeutic agents. <ref>PMID:20614893</ref> |
== Relevance == | == Relevance == | ||
Deficiency of DCK causes resistance to antiviral and chemotherapeutic agents. | Deficiency of DCK causes resistance to antiviral and chemotherapeutic agents. | ||
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| + | == Structural highlights == | ||
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| + | The ability of DCK to phosphorylate multiple nucleosides arises from the different conformations which the active site glutamic acid can assume.<ref>PMID:12808445</ref> | ||
</StructureSection> | </StructureSection> | ||
== 3D Structures of deoxycytidine kinase == | == 3D Structures of deoxycytidine kinase == | ||
Revision as of 08:59, 23 December 2015
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3D Structures of deoxycytidine kinase
Updated on 23-December-2015
References
- ↑ Hazra S, Ort S, Konrad M, Lavie A. Structural and kinetic characterization of human deoxycytidine kinase variants able to phosphorylate 5-substituted deoxycytidine and thymidine analogues . Biochemistry. 2010 Aug 10;49(31):6784-90. PMID:20614893 doi:10.1021/bi100839e
- ↑ Sabini E, Ort S, Monnerjahn C, Konrad M, Lavie A. Structure of human dCK suggests strategies to improve anticancer and antiviral therapy. Nat Struct Biol. 2003 Jul;10(7):513-9. PMID:12808445 doi:http://dx.doi.org/10.1038/nsb942
