Aminotransferase

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Line 51: Line 51:
**[[3hdo]] – HPA – ''Geobacter metallireducens''<br />
**[[3hdo]] – HPA – ''Geobacter metallireducens''<br />
**[[4rae]] – MtHPA – ''Mycobacterium tuberculosis''<br />
**[[4rae]] – MtHPA – ''Mycobacterium tuberculosis''<br />
-
**[[4r8d]] – MtHPA + PLP <br />
+
**[[4r8d]], [[5c6u]] – MtHPA + PLP <br />
*Ornithine aminotransferase
*Ornithine aminotransferase
Line 59: Line 59:
**[[2oat]] – hOA + PLP derivative <br />
**[[2oat]] – hOA + PLP derivative <br />
**[[2byj]], [[2byl]] – hOA (mutant) + PLP <br />
**[[2byj]], [[2byl]] – hOA (mutant) + PLP <br />
 +
**[[5eav]] – TgOA – ''Toxoplasma gondii'' <br />
 +
**[[5eqc]], [[4zwm]] – TgOA + PLP <br />
 +
**[[5e5i]] – TgOA + inactivator <br />
 +
**[[5e3k]] – TgOA + pentanoic acid derivative <br />
 +
**[[5dj9]] – TgOA + gabaculine<br />
*Acetylornithine aminotransferase
*Acetylornithine aminotransferase
Line 78: Line 83:
*Alanine glyoxylate aminotransferase
*Alanine glyoxylate aminotransferase
-
**[[1h0c]], [[2yob]] – hAGA + PLP <br />
+
**[[1h0c]], [[2yob]], [[5f9s]] – hAGA + PLP <br />
**[[4cbr]], [[4cbs]] – hAGA (mutant) + PLP <br />
**[[4cbr]], [[4cbs]] – hAGA (mutant) + PLP <br />
-
**[[1j04]] – hAGA + PLP derivative <br />
+
**[[1j04]], [[5hhy]] – hAGA + PLP derivative <br />
**[[4i8a]] – hAGA (mutant) + PLP derivative <br />
**[[4i8a]] – hAGA (mutant) + PLP derivative <br />
**[[3r9a]] – hAGA + PLP derivative + peroxisomal targeting signal receptor<br />
**[[3r9a]] – hAGA + PLP derivative + peroxisomal targeting signal receptor<br />
Line 97: Line 102:
**[[5daa]] - BaAAT (mutant) + PLP derivative <br />
**[[5daa]] - BaAAT (mutant) + PLP derivative <br />
**[[3lqs]] - BaAAT + thiophenecarboxylic acid<br />
**[[3lqs]] - BaAAT + thiophenecarboxylic acid<br />
 +
**[[4m0j]] - BtAAT – ''Burkholderia thailandensis''<br />
 +
**[[4tm5]] - BtAAT + PLP <br />
*Branched chain amino acid aminotransferase
*Branched chain amino acid aminotransferase
Line 103: Line 110:
**[[1kt8]], [[1kta]] – hBCAT + PLP derivative <br />
**[[1kt8]], [[1kta]] – hBCAT + PLP derivative <br />
**[[2alh]], [[5bwr]], [[5bwt]], [[5bwu]], [[5bwv]], [[5bwx]], [[5bww]], [[5cr5]] – hBCAT + PLP + inhibitor <br />
**[[2alh]], [[5bwr]], [[5bwt]], [[5bwu]], [[5bwv]], [[5bwx]], [[5bww]], [[5cr5]] – hBCAT + PLP + inhibitor <br />
 +
**[[5i60]], [[5i5y]], [[5i5x]], [[5i5w]], [[5i5v]], [[5i5u]], [[5i5t]], [[5i5s]], [[5hne]] – hBCAT + PLP + biaryl amide<br />
**[[2hdk]], [[2hgw]], [[2hgx]], [[2hhf]] – hBCAT (mutant) + PLP <br />
**[[2hdk]], [[2hgw]], [[2hgx]], [[2hhf]] – hBCAT (mutant) + PLP <br />
**[[2hg8]] – hBCAT (mutant) + PLP + methylleucine <br />
**[[2hg8]] – hBCAT (mutant) + PLP + methylleucine <br />
Line 109: Line 117:
**[[4cmd]] – NhBCAT + PLP – ''Nectria haematococca''<br />
**[[4cmd]] – NhBCAT + PLP – ''Nectria haematococca''<br />
**[[4cmf]] – NhBCAT + inhibitor <br />
**[[4cmf]] – NhBCAT + inhibitor <br />
 +
**[[5e25]] – BCAT + PLP + ketoglutarate – ''Geoglobus acetivorans'' <br />
 +
**[[5ce8]] – BCAT + PLP – ''Thermoproteus uzoniensis'' <br />
*Aromatic amino acid aminotransferase
*Aromatic amino acid aminotransferase
Line 170: Line 180:
**[[3r4t]] – GABA + PLP derivative – ''Mycobacterium marinum''<br />
**[[3r4t]] – GABA + PLP derivative – ''Mycobacterium marinum''<br />
**[[4ffc]] – GABA + PLP derivative – ''Mycobacterium abscessus''<br />
**[[4ffc]] – GABA + PLP derivative – ''Mycobacterium abscessus''<br />
 +
**[[4zsy]], [[4zsw]], [[4y0i]], [[4y0h]], [[4y0d]] – GABA + inactivator - pig <br />
*ArnB aminotransferase
*ArnB aminotransferase
Line 184: Line 195:
**[[3hbm]] - CjPseC (mutant)<br />
**[[3hbm]] - CjPseC (mutant)<br />
**[[3hbn]] - CjPseC (mutant) + UDP<br />
**[[3hbn]] - CjPseC (mutant) + UDP<br />
 +
 +
*TlmJ aminotransferase
 +
 +
**[[5uid]] - TlmJ + PLP – ''Streptoalloteichus hindustanus''<br />
*WbpE aminotransferase
*WbpE aminotransferase
Line 191: Line 206:
**[[3nyt]] - PaWbpE (mutant) + PLP derivative<br />
**[[3nyt]] - PaWbpE (mutant) + PLP derivative<br />
-
*Alpha-aminodipate aminotransferase
+
*Alpha-aminoadipate aminotransferase
-
**[[2egy]] - TtLysN + PLP <br />
+
**[[2egy]], [[5eun]] - TtLysN + PLP <br />
**[[3cbf]], [[2zyj]] - TtLysN + PLP derivative<br />
**[[3cbf]], [[2zyj]] - TtLysN + PLP derivative<br />
**[[2zp7]], [[2z1y]] - TtLysN + PLP + leucine<br />
**[[2zp7]], [[2z1y]] - TtLysN + PLP + leucine<br />
 +
**[[5tf5]] - hLysN + PLP derivative + inhibitor<br />
 +
**[[5efs]] - hLysN II <br />
 +
 +
*Broad specificity aminotransferase
 +
 +
**[[4wb0]] - BsAT – Leishmania mexicana<br />
 +
 +
*Adenosylmethionine-8-amino-7-oxononanoate aminotransferase
 +
**[[4w1x]], [[4w1w]], [[4w1v]], [[4xjl]], [[4xjm]], [[4xjo]], [[4xjp]] - MtDAPA + PLP + inhibitor<br />
 +
**[[4mqr]], [[4mqq]], [[4mqp]] - MtDAPA + inhibitor<br />
 +
**[[5uc7]] - DAPA + PLP derivative – ''Citrobacter rodentium''<br />
 +
*Putrescine aminotransferase
 +
**[[4uoy]] - EcPAT + PLP <br />
 +
**[[4uox]] - EcPAT + PLP + putrescine<br />
 +
*Omega amino acid-pyruvate aminotransferase
 +
**[[4uho]], [[4uhn]], [[4uhm]] - PaOAAT + PLP <br />
}}
}}
== References ==
== References ==
<references/>
<references/>

Revision as of 09:31, 5 March 2017

E. coli Histidinol-phosphate aminotransferase complex with PLP (PDB code 1gew)

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3D structures of aminotransferase

Updated on 05-March-2017

References

  1. ↑ Mizuguchi H, Hayashi H, Miyahara I, Hirotsu K, Kagamiyama H. Characterization of histidinol phosphate aminotransferase from Escherichia coli. Biochim Biophys Acta. 2003 Apr 11;1647(1-2):321-4. PMID:12686152
  2. ↑ Kirsch JF, Eichele G, Ford GC, Vincent MG, Jansonius JN, Gehring H, Christen P. Mechanism of action of aspartate aminotransferase proposed on the basis of its spatial structure. J Mol Biol. 1984 Apr 15;174(3):497-525. PMID:6143829 doi:http://dx.doi.org/10.1016/0022-2836(84)90333-4
  3. ↑ Kirsch JF, Eichele G, Ford GC, Vincent MG, Jansonius JN, Gehring H, Christen P. Mechanism of action of aspartate aminotransferase proposed on the basis of its spatial structure. J Mol Biol. 1984 Apr 15;174(3):497-525. PMID:6143829 doi:http://dx.doi.org/10.1016/0022-2836(84)90333-4
  4. ↑ Haruyama K, Nakai T, Miyahara I, Hirotsu K, Mizuguchi H, Hayashi H, Kagamiyama H. Structures of Escherichia coli histidinol-phosphate aminotransferase and its complexes with histidinol-phosphate and N-(5'-phosphopyridoxyl)-L-glutamate: double substrate recognition of the enzyme. Biochemistry. 2001 Apr 17;40(15):4633-44. PMID:11294630

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