This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
Sandbox Reserved 1120
From Proteopedia
(Difference between revisions)
(Première mise en forme de la page + petite intro) |
|||
| Line 3: | Line 3: | ||
==SRY protein (AKA TDF protein)== | ==SRY protein (AKA TDF protein)== | ||
| - | <StructureSection load='1hry' size='340' side='right' caption=' | + | <StructureSection load='1hry' size='340' side='right' caption='The SRY protein linked to DNA' scene=''> |
The SRY protein is a monomeric 203 residues long polypeptide. It is a '''transcriptionnal factor''', more precisely a transcriptionnal activator of the '''M'''üllerian '''In'''hibiting '''S'''ubstance (MIS gene) | The SRY protein is a monomeric 203 residues long polypeptide. It is a '''transcriptionnal factor''', more precisely a transcriptionnal activator of the '''M'''üllerian '''In'''hibiting '''S'''ubstance (MIS gene) | ||
| Line 10: | Line 10: | ||
==History== | ==History== | ||
| + | |||
| + | It has been shown that a mutation of SRY increase male to female sex reversal for 15% '''REF NECESSAIRE''' | ||
==Structure== | ==Structure== | ||
| + | |||
| + | ===The hSRY-HMG domain=== | ||
| + | It is a approximately 80residues domain.. It mediates minor groove DNA binding proteins. | ||
| + | Twisted L shape : Concave surface. 3 helices & N and C end strands. | ||
| + | Binds the DNA by its minor groove. | ||
| + | |||
| + | ===General structure of SRY=== | ||
| + | 3 domains: | ||
| + | * N-term domain | ||
| + | * Central domain | ||
| + | * C-term domain | ||
| + | |||
== Function == | == Function == | ||
| + | ===Sex determining=== | ||
| + | * MSI | ||
C'est une protéine de l'ambiance. Elle peut tout faire. | C'est une protéine de l'ambiance. Elle peut tout faire. | ||
Revision as of 19:35, 30 December 2015
| This Sandbox is Reserved from 15/12/2015, through 15/06/2016 for use in the course "Structural Biology" taught by Bruno Kieffer at the University of Strasbourg, ESBS. This reservation includes Sandbox Reserved 1120 through Sandbox Reserved 1159. |
To get started:
More help: Help:Editing |
SRY protein (AKA TDF protein)
| |||||||||||
