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Sandbox Reserved 1120
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The SRY protein is a monomeric 203 residues long polypeptide. It is a '''transcriptionnal factor''', more precisely a transcriptionnal activator of the '''M'''üllerian '''In'''hibiting '''S'''ubstance ('''MIS''' gene). | The SRY protein is a monomeric 203 residues long polypeptide. It is a '''transcriptionnal factor''', more precisely a transcriptionnal activator of the '''M'''üllerian '''In'''hibiting '''S'''ubstance ('''MIS''' gene). | ||
| - | It is encoded by the human testis-determining sex gene. | + | It is encoded by the [[human testis-determining sex gene]] and is itself involved in the sex determination in mammels by being responsible for the male sexual developement. |
==History== | ==History== | ||
| - | It has been shown that a mutation of SRY increase male to female sex reversal for 15% '''REF NECESSAIRE''' | + | It has been shown that a mutation of SRY increase male to female sex reversal for 15% <font color='red'>'''REF NECESSAIRE'''</font> |
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| + | ==SRY gene== | ||
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| + | The SRY gene encodes the SRY protein. It is located on the Y chromosom. | ||
==Structure== | ==Structure== | ||
| - | ===The | + | ===The SRY-HMG domain=== |
'''SRY-HMG''' stands for '''S'''ex determining '''R'''egion '''Y''' - '''H'''igh '''M'''obility '''D'''omain | '''SRY-HMG''' stands for '''S'''ex determining '''R'''egion '''Y''' - '''H'''igh '''M'''obility '''D'''omain | ||
It is a approximately 80residues domain.. It mediates minor groove DNA binding proteins. | It is a approximately 80residues domain.. It mediates minor groove DNA binding proteins. | ||
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== Function == | == Function == | ||
===Sex determining=== | ===Sex determining=== | ||
| - | + | It acts like a sex determinator thanks to it transcriptionnal activity. It inhibits the developpement of female sex structure in th embryonnic individual. | |
==Implication== | ==Implication== | ||
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</StructureSection> | </StructureSection> | ||
== References == | == References == | ||
| + | [http://ghr.nlm.nih.gov/gene/SRY Genetic Home reference] | ||
<references/> | <references/> | ||
Revision as of 19:56, 30 December 2015
| This Sandbox is Reserved from 15/12/2015, through 15/06/2016 for use in the course "Structural Biology" taught by Bruno Kieffer at the University of Strasbourg, ESBS. This reservation includes Sandbox Reserved 1120 through Sandbox Reserved 1159. |
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SRY protein (AKA TDF protein)
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